Article
Multidisciplinary Sciences
Odette Leiter, David Brici, Stephen J. Fletcher, Xuan Ling Hilary Yong, Jocelyn Widagdo, Nicholas Matigian, Adam B. Schroer, Gregor Bieri, Daniel G. Blackmore, Perry F. Bartlett, Victor Anggono, Saul A. Villeda, Tara L. Walker
Summary: Physical activity has beneficial effects on brain ageing, and platelets secrete an anti-geronic exerkine that mediates the rejuvenating effects of exercise.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Odette Leiter, David Brici, Stephen J. Fletcher, Xuan Ling Hilary Yong, Jocelyn Widagdo, Nicholas Matigian, Adam B. Schroer, Gregor Bieri, Daniel G. Blackmore, Perry F. Bartlett, Victor Anggono, Saul A. Villeda, Tara L. Walker
Summary: Exercise has positive effects on the aging brain, and platelet-released exerkines, such as PF4, mediate these effects. Platelets are activated by exercise and are necessary for exercise-induced increase in precursor cell proliferation in the hippocampus of aged mice. Increasing the levels of the platelet-derived exerkine PF4 improves age-related cognitive impairments through hippocampal neurogenesis. These findings emphasize the role of platelets in the rejuvenating effects of exercise during brain aging.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Alessia Caramello, Christophe Galichet, Karine Rizzoti, Robin Lovell-Badge
Summary: During embryonic development, timely regulation of the switch between radial glial cells, neurons, and astrocytes is crucial for coordinated interactions in the brain. The deletion of the SOX9 gene in early mouse brain development resulted in compromised dentate gyrus development, highlighting the importance of SOX9 in regulating astroglial potential acquisition in the cortical hem. This study demonstrates the formation of a local network between astrocytic and neuronal progenitors from adjacent domains, essential for brain morphogenesis.
Article
Oncology
So Mi Jeon, Je Sun Lim, Su Hwan Park, Jong-Ho Lee
Summary: The study found that Wnt signaling can induce the expression of PFKP independently of beta-catenin, increase PFK enzyme activity, and promote the Warburg effect, cell proliferation, colony formation, and cancer cell migration through PFKP S386 phosphorylation.
Article
Biochemistry & Molecular Biology
Marina Covic, Milorad Zjalic, Lovro Mihajlovic, Marianna Pap, Jasenka Wagner, Dario Mandic, Zeljko Debeljak, Marija Heffer
Summary: This study examined the metabolic effects of sucralose, a non-nutritive sweetener, in a cell model of Parkinson's disease. The results showed that sucralose suppressed the insulin signaling pathway and altered fatty acids and amino acids metabolism. These findings suggest a potential link between diet-induced insulin resistance and neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Elodie Gras Lavigne, Dorothee Buttigieg, Remy Steinschneider, Ethan S. Burstein
Summary: Pimavanserin, a selective 5-HT2A inverse agonist/antagonist, protects dopaminergic neurons against cell death by signaling through the extracellular signal-regulated kinase 1/2 pathway and promoting the release of neurotrophic factors. This neuroprotective effect is dependent on glial-derived neurotrophic factor release and provides potential therapeutic benefits for neurodegenerative disorders.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Michael Gekle, Virginie Dubourg, Gerald Schwerdt, Ralf A. Benndorf, Barbara Schreier
Summary: EGFR plays a critical role in the regulation of vascular function and pathogenesis of cardiovascular diseases through the interplay with AT1R.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Hematology
Imane Boukhatem, Samuel Fleury, Melanie Welman, Jessica Le Blanc, Chantal Thys, Kathleen Freson, Myron G. Best, Thomas Wurdinger, Bruce G. Allen, Marie Lordkipanidze
Summary: Research has shown that circulating BDNF levels appear to regulate platelet activation, aggregation, and secretion through activation of a truncated TrkB receptor and downstream kinase-dependent signaling. BDNF not only plays a role in neurons but also has important functions in platelets.
Review
Geriatrics & Gerontology
Dan Li, Le-Tian Huang, Cheng-pu Zhang, Qiang Li, Jia-He Wang
Summary: This review summarizes the role of platelet-derived growth factors (PDGFs) and platelet-derived growth factor receptors (PDGFRs) in the occurrence and development of Parkinson's disease (PD). The mechanisms by which PDGFs/PDGFRs affect PD include oxidative stress, mitochondrial function, protein folding and aggregation, Ca2+ homeostasis, and cell neuroinflammation. Clinical applications and prospects, especially in genetic treatment, are also discussed. However, contradictory effects of PDGFs within the central nervous system (CNS), such as neuroprotection and disruption of the blood-brain barrier (BBB), are highlighted.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cell Biology
Norimitsu Morioka, Syun Kondo, Nanase Harada, Tomoyo Takimoto, Nozomi Tokunaga, Yoki Nakamura, Kazue Hisaoka-Nakashima, Yoshihiro Nakata
Summary: The study found that Cx43 knockdown can enhance the expression of BDNF mRNA in astrocytes, revealing a novel mechanism mediated by adrenergic receptors.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Dakota F. Brockway, Keith R. Griffith, Chloe M. Aloimonos, Thomas T. Clarity, J. Brody Moyer, Grace C. Smith, Nigel C. Dao, Md Shakhawat Hossain, Patrick J. Drew, Joshua A. Gordon, David A. Kupferschmidt, Nicole A. Crowley
Summary: This study aimed to investigate the unique role of somatostatin (SST) in the prelimbic (PL) cortex of mice. The researchers conducted slice electrophysiology and fiber photometry to characterize the pharmacological mechanism and activity profile of SST neurons. The findings reveal that SST signaling can modulate microcircuits in the prefrontal cortex and affect exploratory behaviors.
Article
Microbiology
Minmin Zhou, Shaobo Wang, Jiao Guo, Yang Liu, Junyuan Cao, Xiaohao Lan, Xiaoying Jia, Bo Zhang, Gengfu Xiao, Wei Wang
Summary: PDGFR beta was identified as a potential therapeutic target against JEV infection, with the inhibitor imatinib showing protection against JEV-induced lethality by reducing viral load in the brain and preventing histopathological changes.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Neurosciences
Jelena Medved, William M. Wood, Michael D. van Heyst, Amin Sherafat, Ju-Young Song, Sagune Sakya, Dennis L. Wright, Akiko Nishiyama
Summary: Oligodendrocyte precursor cells play a crucial role in brain development and have the potential to be targeted for the treatment of brain tumors.
Article
Multidisciplinary Sciences
Seiji Ishii, Toru Sasaki, Shahid Mohammad, Hye Hwang, Edwin Tomy, Fahad Somaa, Nobuyuki Ishibashi, Hideyuki Okano, Pasko Rakic, Kazue Hashimoto-Torii, Masaaki Torii
Summary: Primary cilia play a crucial role in protecting immature neurons from environmental stress by activating signaling pathways that inhibit degeneration of dendritic arbors and caspase-mediated cleavage of cytoskeletal proteins in stress-exposed neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Hematology
Julian Leberzammer, Stijn M. Agten, Xavier Blanchet, Rundan Duan, Hans Ippel, Remco T. A. Megens, Christian Schulz, Maria Aslani, Johan Duchene, Yvonne Doring, Natalie J. Jooss, Pengyu Zhang, Richard Brandl, Konstantin Stark, Wolfgang Siess, Kerstin Jurk, Johan W. M. Heemskerk, Tilman M. Hackeng, Kevin H. Mayo, Christian Weber, Philipp von Hundelshausen
Summary: The study explored the molecular mechanisms of CXCL12 in arterial thrombosis, revealing that inhibition of CXCR4 can attenuate platelet aggregation and limit arterial thrombosis. Mechanistically, CXCL12 activates Btk leading to platelet aggregation, while the interaction between CXCL12 and CCL5 can inhibit this process. A novel peptide was found to inhibit CXCL12-induced platelet aggregation without prolonging bleeding time.
Article
Neurosciences
Jeff S. Kruk, Maryam S. Vasefi, Nyasha Gondora, Nawaz Ahmed, John J. Heikkila, Michael A. Beazely
MOLECULAR AND CELLULAR NEUROSCIENCE
(2015)
Article
Biochemistry & Molecular Biology
Wesseem Osman, Tarek Mohamed, Victor Munsing Sit, Maryam S. Vasefi, Michael A. Beazely, Praveen P. N. Rao
CHEMICAL BIOLOGY & DRUG DESIGN
(2016)
Article
Clinical Neurology
Hui Liu, Golam T. Saffi, Maryam S. Vasefi, Youngjik Choi, Jeff S. Kruk, Nawaz Ahmed, Nyasha Gondora, John Mielke, Zoya Leonenko, Michael A. Beazely
CURRENT ALZHEIMER RESEARCH
(2018)
Article
Nanoscience & Nanotechnology
Samih Alqawlaq, Jeremy M. Sivak, J. Torin Huzil, Marina V. Ivanova, John G. Flanagan, Michael A. Beazely, Marianna Foldvari
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2014)
Article
Biochemistry & Molecular Biology
Morgan Robinson, Jennifer Lou, Banafsheh Mehrazma, Arvi Rauk, Michael Beazely, Zoya Leonenko
Summary: The study examined three SG inhibitors, with two showing neuroprotective effects against A beta(1-42) oligomers and one showing no effect. Myristoylation of the inhibitors improved delivery across the blood-brain barrier but resulted in cytotoxicity. The findings will inform the future development of peptide aggregation inhibitors against A beta toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Vikas Parihar, Michael A. Beazely, Laura Katz, Rita Dhami, Lisa Laureen Patterson
Summary: After completing an accredited cannabis course, pharmacy students at the University of Waterloo reported feeling more knowledgeable and prepared to interact with patients using medical and recreational cannabis. They also showed greater caution regarding the therapeutic use of cannabis and believed in the need for increased oversight.
CANADIAN PHARMACISTS JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Ashley Cid, Alec Patten, Kelly Grindrod, Michael A. Beazely
CANADIAN PHARMACISTS JOURNAL
(2021)
Article
Pharmacology & Pharmacy
George Daskalakis, Ashley Cid, Kelly Grindrod, Michael A. Beazely
Summary: During the COVID-19 pandemic, a report in Ontario showed an increase in opioid-related deaths compared to before the pandemic. A study with 231 pharmacy professionals found that while some reported an increase in naloxone dispensing, others reported a decrease. The most common adjustments made during the pandemic were training patients remotely and offering naloxone at prescription intake.
Article
Public, Environmental & Occupational Health
Wajd Alkabbani, Ryan Pelletier, Michael A. Beazely, Youssef Labib, Breanna Quan, John-Michael Gamble
Summary: The reporting of myopathy cases does not appear to be significantly higher among individuals using both SGLT-2i and statins compared to those using either SGLT-2i or statins alone.
Article
Biochemistry & Molecular Biology
Marzie Khavandi, Praveen P. N. Rao, Michael A. A. Beazely
Summary: The regulation and metabolism of the endocannabinoid system show potential neuroprotective effects in Alzheimer's disease by inhibiting Aβ aggregation and reducing cell toxicity. This study demonstrates the role and application of endocannabinoids in AD pathology and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Ashley Cid, George Daskalakis, Kelly Grindrod, Michael A. Beazely
Summary: Multiple new sources describing community pharmacy-based take-home naloxone (THN) programs have emerged recently, emphasizing the need to define program types for future research. This paper summarizes literature on THN programs, including interventions, barriers, and knowledge gaps in community pharmacy settings.
Article
Pharmacology & Pharmacy
Randy So, Yazid Al Hamarneh, Mark Barnes, Michael A. Beazely, Michael Boivin, Julie Laroche, Harsit Patel, Aaron Sihota, Tim Smith, Ross T. Tsuyuki
CANADIAN PHARMACISTS JOURNAL
(2020)
Article
Pharmacology & Pharmacy
Ross T. Tsuyuki, Vinita Arora, Mark Barnes, Michael A. Beazely, Michael Boivin, Anna Christofides, Harsit Patel, Julie Laroche, Aaron Sihota, Randy So
CANADIAN PHARMACISTS JOURNAL
(2020)
Article
Substance Abuse
Dulcie Lai, Amy Trinh Pham, Praveen P. Nekkar Rao, Michael A. Beazely
HARM REDUCTION JOURNAL
(2019)
Article
Multidisciplinary Sciences
Ryan M. Bradley, Emily B. Mardian, Phillip M. Marvyn, Maryam S. Vasefi, Michael A. Beazely, John G. Mielke, Robin E. Duncan
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)
