The Role of AKT/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and Senescence

Cell cycle arrest is not senescence

(2016) Mikhail V. Blagosklonny   Aging-US

Induction of Heat Shock Protein 70 Ameliorates Ultraviolet-Induced Photokeratitis in Mice

(2013) Anton Lennikov et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy

(2013) Chih-Hung Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Altered Nucleotide Excision Repair and UVB-Induced DNA Damage in Melanomagenesis

(2013) Timothy Budden et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy Has a Significant Role in Determining Skin Color by Regulating Melanosome Degradation in Keratinocytes

(2013) Daiki Murase et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Senescence and aging: the critical roles of p53

(2013) A Rufini et al.   ONCOGENE

Ligand-activated PPARδ inhibits UVB-induced senescence of human keratinocytes via PTEN-mediated inhibition of superoxide production

(2012) Sun Ah Ham et al.   BIOCHEMICAL JOURNAL

Inhibition of mTOR Suppresses UVB-Induced Keratinocyte Proliferation and Survival

(2012) T. D. Carr et al.   Cancer Prevention Research

Functional Protein Pathway Activation Mapping of the Progression of Normal Skin to Squamous Cell Carcinoma

(2012) J. G. Einspahr et al.   Cancer Prevention Research

Perifosine sensitizes UVB-induced apoptosis in skin cells: New implication of skin cancer prevention?

(2012) Chao Ji et al.   CELLULAR SIGNALLING

Changes in mitochondrial DNA alter expression of nuclear encoded genes associated with tumorigenesis

(2012) Jana Jandova et al.   EXPERIMENTAL CELL RESEARCH

Protein kinase B/Akt1 inhibits autophagy by down-regulating UVRAG expression

(2012) Wonseok Yang et al.   EXPERIMENTAL CELL RESEARCH

Targeting Protective Autophagy Exacerbates UV-Triggered Apoptotic Cell Death

(2012) Li-Hsin Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GSK3β signaling is involved in ultraviolet B-induced activation of autophagy in epidermal cells

(2012) YANG YANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Suppression of PTEN Transcription by UVA

(2012) Baozhong Zhao et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Functional HSF1 requires aromatic-participant interactions in protecting mouse embryonic fibroblasts against apoptosis via G2 cell cycle arrest

(2012) Ziwei Chang et al.   MOLECULES AND CELLS

Shining Light on Skin Pigmentation: The Darker and the Brighter Side of Effects of UV Radiation†

(2012) Nityanand Maddodi et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Differential Activation of Signaling Pathways by UVA and UVB Radiation in Normal Human Epidermal Keratinocytes†

(2012) Deeba N. Syed et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Alkannin, HSP70 Inducer, Protects against UVB-Induced Apoptosis in Human Keratinocytes

(2012) Yoko Yoshihisa et al.   PLoS One

Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment

(2012) Frances P. Noonan et al.   Nature Communications

Autophagy and Cancer

(2012) Francesca Aredia et al.   Cells

Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability

(2012) Naihan Xu et al.   Journal of Oncology

Cell death pathology: Cross-talk with autophagy and its clinical implications

(2011) Ivano Amelio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling

(2011) Sharon Biton et al.   CELL

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks

(2011) Michael Fraser et al.   CELL CYCLE

UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation

(2011) Xiaocheng Yin et al.   EMBO REPORTS

Infrared radiation does not enhance the frequency of ultraviolet radiation-induced skin tumors, but their growth behaviour in mice

(2011) Christian Jantschitsch et al.   EXPERIMENTAL DERMATOLOGY

Protein Kinases and Transcription Factors Activation in Response to UV-Radiation of Skin: Implications for Carcinogenesis

(2011) César López-Camarillo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chromatin Structure Following UV-Induced DNA Damage—Repair or Death?

(2011) Andrew W. Farrell et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA damage and autophagy

(2011) Humberto Rodriguez-Rocha et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase

(2011) M. Kawasumi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition

(2011) P. M. Krawczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative regulation of autophagy

(2010) C Liang   CELL DEATH AND DIFFERENTIATION

PI(3)King Apart PTEN's Role in Cancer

(2010) S. Zhang et al.   CLINICAL CANCER RESEARCH

Autophagy regulation by p53

(2010) Maria Chiara Maiuri et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of the JNK/Bim pathway by Hsp70 prevents Bax activation in UV-induced apoptosis

(2010) Hui Li et al.   FEBS LETTERS

Aldose reductase in keratinocytes attenuates cellular apoptosis and senescence induced by UV radiation

(2010) Eun Sil Kang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Suppression of Melanin Production by Expression of HSP70

(2010) Tatsuya Hoshino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

Mechanisms of mutation formation with long-wave ultraviolet light (UVA)

(2010) Thomas M. Rünger et al.   PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE

Paradoxical suppression of cellular senescence by p53

(2010) Z. N. Demidenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melanocytes are deficient in repair of oxidative DNA damage and UV-induced photoproducts

(2010) H.-T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

(2010) E Wirawan et al.   Cell Death & Disease

Erbb2 Suppresses DNA Damage-Induced Checkpoint Activation and UV-Induced Mouse Skin Tumorigenesis

(2009) Justin G. Madson et al.   AMERICAN JOURNAL OF PATHOLOGY

The Role of BRAF Mutation and p53 Inactivation during Transformation of a Subpopulation of Primary Human Melanocytes

(2009) Hong Yu et al.   AMERICAN JOURNAL OF PATHOLOGY

The UV response of the skin: a review of the MAPK, NFκB and TNFα signal transduction pathways

(2009) Visalini Muthusamy et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Activation of the mammalian target of rapamycin signalling pathway in epidermal tumours and its correlation with cyclin-dependent kinase 2

(2009) S-J. Chen et al.   BRITISH JOURNAL OF DERMATOLOGY

Heat stress upregulates chaperone heat shock protein 70 and antioxidant manganese superoxide dismutase through reactive oxygen species (ROS), p38MAPK, and Akt

(2009) Soumyajit Banerjee Mustafi et al.   CELL STRESS & CHAPERONES

Autophagy and tumorigenesis

(2009) Nan Chen et al.   FEBS LETTERS

Parameters of protection against ultraviolet radiation-induced skin cell damage

(2009) Cong Cao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes

(2009) M Ming et al.   ONCOGENE

Requirement for Metalloproteinase-dependent ERK and AKT Activation in UVB-induced G1-S Cell Cycle Progression of Human Keratinocytes

(2009) Weinong Han et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

UVA-Induced Cell Cycle Progression Is Mediated by a Disintegrin and Metalloprotease/Epidermal Growth Factor Receptor/AKT/Cyclin D1 Pathways in Keratinocytes

(2008) Y.-Y. He et al.   CANCER RESEARCH

Development of thermotolerance requires interaction between polymerase-β and heat shock proteins

(2008) Akihisa Takahashi et al.   CANCER SCIENCE

Identification of PP2A as a crucial regulator of the NF-κB feedback loop: its inhibition by UVB turns NF-κB into a pro-apoptotic factor

(2008) S Barisic et al.   CELL DEATH AND DIFFERENTIATION

To Die or Not to Die: That is the Autophagic Question

(2008) Maria Maiuri et al.   CURRENT MOLECULAR MEDICINE

AMP-activated Protein Kinase Contributes to UV- and H2O2-induced Apoptosis in Human Skin Keratinocytes

(2008) Cong Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HSP70i Accelerates Depigmentation in a Mouse Model of Autoimmune Vitiligo

(2008) Cecele J. Denman et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Infrared Radiation Confers Resistance to UV-Induced Apoptosis Via Reduction of DNA Damage and Upregulation of Antiapoptotic Proteins

(2008) Christian Jantschitsch et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

UVB-induced Senescence in Human Keratinocytes Requires a Functional Insulin-like Growth Factor-1 Receptor and p53

(2008) Davina A. Lewis et al.   MOLECULAR BIOLOGY OF THE CELL

The p53 family and programmed cell death

(2008) E C Pietsch et al.   ONCOGENE

PI3K/Akt: getting it right matters

(2008) T F Franke   ONCOGENE

Mitochondrial dysfunction and cellular stress progression after ultraviolet B irradiation in human keratinocytes

(2008) Mariela L. Paz et al.   PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE

Downregulation of Melanin Synthesis by Haginin A and Its Application to In Vivo Lightening Model

(2007) Jin Hee Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY