Review
Biochemistry & Molecular Biology
Francesco Balestri, Roberta Moschini, Umberto Mura, Mario Cappiello, Antonella Del Corso
Summary: This article introduces the role of aldose reductase (AKR1B1) in diabetic complications and the development of its inhibitors. Currently, the synthesized inhibitors have failed to become drugs for the treatment of diabetic complications. The article proposes a differential inhibition approach that has the potential to become a new generation of inhibitors.
Article
Pharmacology & Pharmacy
Kaveri M. Adki, Yogesh A. Kulkarni
Summary: This study demonstrates the effectiveness of paeonol in the management of diabetic retinopathy. Paeonol treatment significantly improved retinal physiology, reduced blood glucose levels and oxidative stress, and alleviated histopathological changes in the retina.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gemma Sardelli, Viola Scali, Giovanni Signore, Francesco Balestri, Mario Cappiello, Umberto Mura, Antonella Del Corso, Roberta Moschini
Summary: A common feature of different types of diabetes is high blood glucose levels, which can cause metabolic alterations and tissue damage. Two key factors in this response are increased polyol pathway flux and oxidative stress. This study investigated the effects of stress conditions, specifically high glucose levels and the lipid peroxidation product 4-hydroxy-2-nonenal, on a human lens epithelial cell line. The study found that both stress conditions induced the expression of COX-2, but only hyperglycemic stress activated NF-kappa B. The role of aldose reductase was found to be important in cellular detoxification against lipid peroxidation products, but not in controlling the onset of inflammatory phenomena.
Article
Polymer Science
Cheolwoo Park, Jaeyoung Park, Won-Jin Kim, Woong Kim, Hyeonsook Cheong, Seok-Jun Kim
Summary: The study showed that malonic acid (MA) from Pinus densiflora protects against UVB-induced photoaging by reducing ROS levels and inhibiting skin inflammation.
Article
Biochemistry & Molecular Biology
In Ah Bae, Jae Won Ha, Joon Yong Choi, Yong Chool Boo
Summary: The antioxidant effect of Korean propolis on oxidative stress in human epidermal keratinocytes exposed to air particulate matter was studied. The hydrophilic fraction of propolis showed potential in inhibiting oxidative stress induced by particulate matter and reducing toxicity.
Article
Medicine, Research & Experimental
Safaa I. Khater, Amany Abdel-Rahman Mohamed, Ahmed Hamed Arisha, Lamiaa L. M. Ebraheim, Shefaa A. M. El-Mandrawy, Mohamed A. Nassan, Amany Tharwat Mohammed, Samar Ahmed Abdo
Summary: This study investigates the beneficial effects of chitosan stabilized nanoparticles Ch-SeNPs on combating diabetic nephropathy in rats with induced T2DM. Combined treatment with Ch-SeNPs and metformin showed significant improvements in kidney protection, reducing renal tissue injury, inhibiting oxidative stress, and restoring glucose hemostasis, providing a promising approach for treating T2DM nephropathy.
Article
Multidisciplinary Sciences
Ju Hwan Kim, Dong-Jun Kang, Jun-Sang Bae, Jai Hyuen Lee, Sangbong Jeon, Hyung-Do Choi, Nam Kim, Hyung-Gun Kim, Hak Rim Kim
Summary: Exposure to 1760 MHz RF-EMF induces ROS generation in HaCaT human keratinocytes, leading to activation of MMP and phosphorylation of FoxO3a and ERK1/2 related to skin aging.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Jia-yi He, Quan Hong, Bi-xia Chen, Shao-yuan Cui, Ran Liu, Guang-yan Cai, Jiao Guo, Xiang-mei Chen
Summary: Panax notoginseng, a traditional Chinese medicine, has beneficial effects on diabetic kidney disease (DKD) by alleviating podocyte injury through inhibiting apoptosis and mitochondrial damage. Rb1, the main active ingredient of Panax notoginseng, combines with aldose reductase to effectively mitigate the progression of diabetic kidney disease.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Xiao Cui, Yongshi Ma, Hong Wang, Jianfang Huang, Linlin Li, Jianbing Tang, Biao Cheng
Summary: The study demonstrated that pre- and post-treatment of PRP could reduce MDA content and increase antioxidant enzyme activities in UVB-damaged HaCaT cells. Additionally, PRP intervention promoted cell proliferation via PI3K/AKT pathway, suppressed the expression of gamma-H2AX, upregulated TIMP-1 expression while downregulating MMP expression levels in photoaged HaCaT cells, ultimately playing an anti-photoaging role.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Engineering, Environmental
You Zhang, Wenhong Fan, Xiaomin Li, Wen-Xiong Wang, Shu Liu
Summary: In this study, nanobubble technology and hydrogen water were combined for the first time to remove reactive oxygen species caused by environmental stress. Hydrogen nanobubbles showed remarkable capability in removing H2O2 and O(2)(center dot- ), and increasing the activity and expression of antioxidant enzymes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mahavir Singh, Aniruddh Kapoor, Aruni Bhatnagar
Summary: Aldose reductase (AR) plays a key role in the development of diabetic complications, and its inhibition may have both beneficial and harmful effects. Research suggests that inhibition of AR could modify the effects of cardiovascular disease, asthma, neuropathy, sepsis, and cancer.
Article
Biochemistry & Molecular Biology
Leanne E. Mocniak, Zachary T. Bitzer, Neil Trushin, John P. Richie
Summary: Tobacco smoke free radicals, which depend on the intrinsic nitrate levels in tobacco, are closely associated with adverse health effects. The levels of gas phase radicals are highly correlated with nitrate levels in different tobacco types and brands. Nitrate addition to tobacco leaves increases the production of gas phase radicals and NNK in smoke. Tobacco nitrate plays a key role in the production of gas phase radicals and has implications for health regulation.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mario Abate, Marianna Citro, Simona Pisanti, Mariella Caputo, Rosanna Martinelli
Summary: The study revealed that 3-hydroxytyrosol promotes keratinocyte proliferation and migration, potentially aiding in wound healing and re-epithelialization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ilandarage Menu Neelaka Molagoda, Mirissa Hewage Dumindu Kavinda, Yung Hyun Choi, Hyesook Lee, Chang-Hee Kang, Mi-Hwa Lee, Chang-Min Lee, Gi-Young Kim
Summary: The study showed that fisetin can effectively prevent PM2.5-induced apoptosis by inhibiting the ER stress response and production of reactive oxygen species (ROS).
Article
Cardiac & Cardiovascular Systems
Kai Chen, Shirley Wang, Qiwei Wilton Sun, Bo Zhang, Mujib Ullah, Zhongjie Sun
Summary: This study investigates the role of Klotho in cardiac aging, revealing that Klotho deficiency causes cardiac aging through impairing the Nrf2-GR pathway. Supplement of exogenous secreted Klotho represents a promising therapeutic strategy for aging-associated cardiomyopathy and heart failure.
CIRCULATION RESEARCH
(2021)
Article
Toxicology
Masato Katsuyama, En Kimura, Masakazu Ibi, Kazumi Iwata, Misaki Matsumoto, Nozomi Asaoka, Chihiro Yabe-Nishimura
Summary: Clioquinol, a chelator and ionophore of copper/zinc, was previously used as an amebicide but was withdrawn from the market in Japan due to its association with an increase in subacute myelo-optic neuropathy (SMON). The study revealed that clioquinol disrupts cellular copper transport, leading to neurotoxicity in SMON.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xueqing Zhang, Masakazu Ibi, Ryu Haga, Kazumi Iwata, Misaki Matsumoto, Nozomi Asaoka, Junjie Liu, Masato Katsuyama, Chihiro Yabe-Nishimura
Summary: The study found that NOX1/NADPH oxidase plays a crucial role in behavioral and anatomical abnormalities in a maternal immune activation model, possibly affecting behavioral phenotypes in ASD by promoting the loss of Purkinje cells in the cerebellum.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Jin-Hoi Kim
Summary: Several studies have demonstrated the molecular mechanisms involved in the biogenesis and release of exosomes. PtNPs were shown to enhance exosome secretion in A549 cells by inducing oxidative stress and the ceramide pathway. Pre-treatment with NAC could inhibit the PtNPs-induced exosome biogenesis and release.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Neurosciences
Nozomi Asaoka, Masakazu Ibi, Hikari Hatakama, Koki Nagaoka, Kazumi Iwata, Misaki Matsumoto, Masato Katsuyama, Shuji Kaneko, Chihiro Yabe-Nishimura
Summary: The study revealed that NOX1 regulates repetitive behavior in mice by facilitating excitatory synaptic inputs in the central striatum. Deficiency or inhibition of NOX1 can significantly reduce repeated D-2 receptor stimulation-induced repetitive behavior without affecting motor responses.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Hye-sun Cho, Munjeong Choi, Yunjung Lee, Hyoim Jeon, Byeongyong Ahn, Nagasundarapandian Soundrarajan, Kwonho Hong, Jin-Hoi Kim, Chankyu Park
Summary: The study found that using broad-spectrum antimicrobial peptide PMAP-36 can effectively isolate high-quality RNA from various bacteria, providing an efficient method for nucleic acid isolation. Additionally, the use of PMAP-36 also successfully isolates high-quality genomic DNA from challenging bacterial strains, offering a new option for microbiome research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Min-Hee Kang, Muhammad Qasim, Khalid Khan, Jin-Hoi Kim
Summary: Extracellular vesicles (EVs) are a diverse group of membrane-bound vesicles that function as messengers between cells. Much remains unknown about their biogenesis, cargo sorting, and potential therapeutic applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Jin-Hoi Kim
Summary: This study demonstrates for the first time that PdNPs stimulate exosome biogenesis and release in THP-1 cells, simultaneously increasing levels of cytokines and chemokines by modulating various physiological processes. These findings offer a rational approach to enhancing exosome production for various therapeutic applications.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Sangiliyandi Gurunathan, Muhammad Qasim, Min-Hee Kang, Jin-Hoi Kim
Summary: Cancer is the second leading cause of death worldwide, and melatonin has been shown to have oncostatic and anticancer properties by directly affecting carcinogenesis and indirectly disrupting the circadian cycle.
ONCOTARGETS AND THERAPY
(2021)
Article
Immunology
Hansam Cho, Yuyeon Jang, Ki-Hoon Park, Hanul Choi, Aleksandra Nowakowska, Hee-Jung Lee, Minjee Kim, Min-Hee Kang, Jin-Hoi Kim, Ha Youn Shin, Yu-Kyoung Oh, Young Bong Kim
Summary: A recombinant baculoviral vector-based DNA vaccine system against MERS-CoV and SARS-CoV2 was reported, showing high efficacy in preventing viral infections in animal models.
Article
Biology
Kanako Ikami, Nafisa Nuzhat, Haley Abbott, Ronald Pandoy, Lauren Haky, Allan C. Spradling, Heather Tanner, Lei Lei
Summary: Interactions between sister germ cells through intercellular bridges play a critical role in oocyte differentiation during mouse fetal ovary development. Loss of the TEX14 protein results in altered germ cell connectivity within cysts, affecting oocyte development and production in mutant mice. These findings demonstrate the essential link between the nature of fetal germline cysts and oocyte differentiation and development.
Article
Agriculture, Dairy & Animal Science
S. Youk, M. T. Le, M. Kang, B. Ahn, M. Choi, K. Kim, T. H. Kim, J. H. Kim, C. S. Ho, C. Park
Summary: A high-resolution typing method was developed for swine leukocyte antigen 3 (SLA-3), identifying 21 alleles with four novel ones, although the allelic diversity of SLA-3 was lower compared to SLA-1 and -2. More SLA-3 alleles were observed in Landrace and Yorkshire breeds, with SLA-3*04:01 being the most widely distributed allele across all breeds. This method aids in analyzing major SLA genes from field samples, enhancing understanding of immune responses and genetic makeup.
Review
Agriculture, Dairy & Animal Science
Sangiliyandi Gurunathan, Min-Hee Kang, Hyuk Song, Nam Hyung Kim, Jin-Hoi Kim
Summary: Extracellular vesicles (EVs) are nanosized membrane-enclosed compartments that act as messengers in cell-to-cell communication. They influence the phenotype and function of recipient cells by transferring functional proteins and genetic information. Various types of EVs are present in biological fluids, carrying cargoes such as lipids, proteins, and nucleic acids. EVs associated with the reproductive system play a significant role in regulating physiological events such as gamete maturation, fertilization, and embryo and fetal development.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sangiliyandi Gurunathan, Ah Reum Lee, Jin Hoi Kim
Summary: SARS-CoV-2 has caused a pandemic of COVID-19, and some patients have acquired secondary infections such as black fungus disease. Prompt diagnosis and treatment are necessary to prevent high mortality and morbidity rates. Uncontrolled diabetes and immunosuppression are major risk factors, and the use of steroids can increase the risk of black fungus infection. Novel and effective antimicrobial agents are needed to combat this infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Sangiliyandi Gurunathan, Jin Hoi Kim
Summary: Graphene oxide (GO) stimulates exosome biogenesis and release in human ovarian cancer cells (SKOV3), indicating its potential as a tool for targeting the exosome pathway.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ruolei Wang, Lirong Liang, Misaki Matsumoto, Kazumi Iwata, Atsushi Umemura, Feng He
Summary: The imbalance between reactive oxygen species (ROS) production and clearance causes oxidative stress and plays a central role in regulating cell and tissue physiology and pathology. ROS can either stimulate cancer survival and growth or cause cell death depending on their concentration. The transcription factor NRF2 has dual roles in carcinogenesis, where short-term activation suppresses tissue injury, inflammation, and cancer initiation, while constitutive activation confers advantages for cancer cells' survival and growth. NRF2 hyperactivation, as an adaptive cancer phenotype, regulates multiple aspects of cancer development, metastasis, and resistance to anticancer therapy.
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)