Membrane Trafficking of Death Receptors: Implications on Signalling

Fas/CD95-Induced Chemokines Can Serve as “Find-Me” Signals for Apoptotic Cells

(2013) Sean P. Cullen et al.   MOLECULAR CELL

Expression of death receptor-3 in human breast cancer and its functional effects on breast cancer cells in vitro

(2013) ZHICHENG GE et al.   ONCOLOGY REPORTS

Death receptor 3 is essential for generating optimal protective CD41 T-cell immunity against Salmonella

(2012) Sarah L. Buchan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosome

(2012) Maximilian L. Würstle et al.   EXPERIMENTAL CELL RESEARCH

TRAIL: not just for tumors anymore?

(2012) Chris A. Benedict et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice

(2012) Kathrin Steinwede et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension

(2012) Abdul G. Hameed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Precise Mapping of the CD95 Pre-Ligand Assembly Domain

(2012) Valérie Edmond et al.   PLoS One

The Transmembrane Domains of TNF-Related Apoptosis-Inducing Ligand (TRAIL) Receptors 1 and 2 Co-Regulate Apoptotic Signaling Capacity

(2012) Simon Neumann et al.   PLoS One

Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3

(2011) Nicolas Porquet et al.   BMC CANCER

(Un)expected roles of c-IAPs in apoptotic and NFκB signaling pathways

(2011) Eugene Varfolomeev et al.   CELL CYCLE

How CD95 stimulates invasion

(2011) Ernst J.A. Steller et al.   CELL CYCLE

The regulation of TNF signalling: what a tangled web we weave

(2011) John Silke   CURRENT OPINION IN IMMUNOLOGY

Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1

(2011) Filip Van Hauwermeiren et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Origin and evolution of TNF and TNF receptor superfamilies

(2011) Gregory D. Wiens et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

The death receptor CD95 activates the cofilin pathway to stimulate tumour cell invasion

(2011) Ernst J A Steller et al.   EMBO REPORTS

S-Nitrosylation of the Death Receptor Fas Promotes Fas Ligand–Mediated Apoptosis in Cancer Cells

(2011) Lissbeth Leon-Bollotte et al.   GASTROENTEROLOGY

TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation

(2011) Françoise Meylan et al.   IMMUNOLOGICAL REVIEWS

High Cell Surface Death Receptor Expression Determines Type IVersusType II Signaling

(2011) Xue Wei Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Adaptor Protein TRADD Is Essential for TNF-Like Ligand 1A/Death Receptor 3 Signaling

(2011) Y. L. Pobezinskaya et al.   JOURNAL OF IMMUNOLOGY

Hedgehog Inhibition Promotes a Switch from Type II to Type I Cell Death Receptor Signaling in Cancer Cells

(2011) Satoshi Kurita et al.   PLoS One

Modulation of the CD95-Induced Apoptosis: The Role of CD95 N-Glycosylation

(2011) Olga M. Shatnyeva et al.   PLoS One

TRAIL-R4 Promotes Tumor Growth and Resistance to Apoptosis in Cervical Carcinoma HeLa Cells through AKT

(2011) Najoua Lalaoui et al.   PLoS One

Therapeutic Targeting of CD95 and the TRAIL Death Receptors

(2011) Jeannette Gerspach et al.   Recent Patents on Anti-Cancer Drug Discovery

Regulating TRAIL Receptor-Induced Cell Death at the Membrane: A Deadly Discussion

(2011) Sarah Shirley et al.   Recent Patents on Anti-Cancer Drug Discovery

TNF superfamily in inflammatory disease: translating basic insights

(2011) Michael Croft et al.   TRENDS IN IMMUNOLOGY

Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation

(2010) M Ehrenschwender et al.   CELL DEATH AND DIFFERENTIATION

Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes

(2010) Bärbel Edelmann et al.   EMBO JOURNAL

The TNF-Like Protein 1A-Death Receptor 3 Pathway Promotes Macrophage Foam Cell Formation In Vitro

(2010) J. E. McLaren et al.   JOURNAL OF IMMUNOLOGY

The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation

(2010) F Meylan et al.   Mucosal Immunology

CD95 promotes tumour growth

(2010) Lina Chen et al.   NATURE

A Screen for Endocytic Motifs

(2010) Patrycja Kozik et al.   TRAFFIC

Regulation of death receptor signaling by the ubiquitin system

(2009) I E Wertz et al.   CELL DEATH AND DIFFERENTIATION

Life and death by death receptors

(2009) Maria Eugenia Guicciardi et al.   FASEB JOURNAL

Death Receptor 5 Internalization Is Required for Lysosomal Permeabilization by TRAIL in Malignant Liver Cell Lines

(2009) Yuko Akazawa et al.   GASTROENTEROLOGY

The Many Roles of FAS Receptor Signaling in the Immune System

(2009) Andreas Strasser et al.   IMMUNITY

Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-κB

(2009) Imtiyaz Murtaza et al.   INTERNATIONAL JOURNAL OF CANCER

Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas

(2009) Vikas Anathy et al.   JOURNAL OF CELL BIOLOGY

Role of TL1A in the Pathogenesis of Rheumatoid Arthritis

(2009) J. Zhang et al.   JOURNAL OF IMMUNOLOGY

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase

(2009) Benjamin Yazdanpanah et al.   NATURE

XIAP discriminates between type I and type II FAS-induced apoptosis

(2009) Philipp J. Jost et al.   NATURE

Yes and PI3K Bind CD95 to Signal Invasion of Glioblastoma

(2008) Susanne Kleber et al.   CANCER CELL

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

The extracellular glycosphingolipid-binding motif of Fas defines its internalization route, mode and outcome of signals upon activation by ligand

(2008) K Chakrabandhu et al.   CELL DEATH AND DIFFERENTIATION

The mitochondrial serine protease HtrA2/Omi: an overview

(2008) L Vande Walle et al.   CELL DEATH AND DIFFERENTIATION

CARP-2 Is an Endosome-Associated Ubiquitin Ligase for RIP and Regulates TNF-Induced NF-κB Activation

(2008) Wentao Liao et al.   CURRENT BIOLOGY

TL1A (TNFSF15) Regulates the Development of Chronic Colitis by Modulating Both T-Helper 1 and T-Helper 17 Activation

(2008) Hidetoshi Takedatsu et al.   GASTROENTEROLOGY

The TNF-Family Receptor DR3 is Essential for Diverse T Cell-Mediated Inflammatory Diseases

(2008) Françoise Meylan et al.   IMMUNITY

Alix and ALG-2 Are Involved in Tumor Necrosis Factor Receptor 1-induced Cell Death

(2008) Anne-Laure Mahul-Mellier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

(2008) Bhanu P. Pappu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

(2008) Noula Shembade et al.   NATURE IMMUNOLOGY