Article
Cell Biology
Yingming Jiang, Jintuan Huang, Zhenze Huang, Weiyao Li, Rongchang Tan, Tuoyang Li, Zijian Chen, Xiaocheng Tang, Yandong Zhao, Jun Qiu, Chujun Li, Hao Chen, Zuli Yang
Summary: This study found that ADAMTS12 plays a role in promoting tumor development and angiogenic activity in gastric cancer. High expression of ADAMTS12 is associated with chemoresistance and worse overall survival outcomes.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Shi-Xiong Liu, Yun Zhou, Li Zhao, Ling -Shan Zhou, Jie Sun, Ge-Jing Liu, Ying-Shi Du, Yong-Ning Zhou
Summary: The study found that FOXM1 expression levels were significantly up-regulated in human gastric cancer cell lines and tissues, and its expression was higher in patients with metastasis. Suppression of FOXM1 with its inhibitor THIO significantly inhibited the proliferation of gastric cancer cells, induced apoptosis, and suppressed migration, invasion, and angiogenesis. Furthermore, THIO promoted drug-resistant gastric cancer cells to chemotherapies and inhibited the epithelial-mesenchymal transition (EMT) process. These findings suggest that FOXM1 is a promising therapeutic target for gastric cancer treatment and THIO has potential as a therapeutic agent for the disease.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Zhenyuan Li, Tailiang Lu, Zhian Chen, Xiang Yu, Lingzhi Wang, Guodong Shen, Huilin Huang, Zhenhao Li, Yingxin Ren, Weihong Guo, Yanfeng Hu
Summary: Most early stage gastric cancer patients do not have lymph node metastases, but metastases appear in the advanced stage. However, some patients have lymph node metastases in the early stage and none in the advanced stage. To explore the molecular mechanisms involved, clinical samples were collected from patients with early and advanced stage gastric cancer with and without lymph node metastases, as well as metastatic lymph nodes. HOXA11 was identified as a key target that is upregulated in gastric cancer tissues and closely associated with lymphatic metastases. HOXA11 transcriptionally regulates TGF beta 1 expression, activates the TGF beta 1/Smad2 pathway, promotes EMT development, induces VEGF-C secretion, and lymphangiogenesis. These findings provide a plausible mechanism for HOXA11-modulated tumor lymphatic metastasis and suggest HOXA11 as a potential therapeutic target for LN-metastatic gastric cancer.
Article
Chemistry, Multidisciplinary
Jun-Nian Zhou, Biao Zhang, Hai-Yang Wang, Dong-Xing Wang, Ming-Ming Zhang, Min Zhang, Xiao-Kui Wang, Shi-Yong Fan, Ying-Chen Xu, Quan Zeng, Ya-Li Jia, Jia-Fei Xi, Xue Nan, Li-Juan He, Xin-Bo Zhou, Song Li, Wu Zhong, Wen Yue, Xue-Tao Pei
Summary: The compound phenyl-2-pyrimidinyl ketone 4-ally)-3-amino selenourea (CU27) shows inhibitory effects on cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) by inhibiting the transcription activity of c-Myc, suggesting its potential as a therapeutic for sorafenib-resistant HCC.
Article
Oncology
Gang Yan, Meiou Dai, Sophie Poulet, Ni Wang, Julien Boudreault, Girija Daliah, Suhad Ali, Jean-Jacques Lebrun
Summary: This study used a combined in vitro/in vivo genome-wide CRISPR screening approach to identify targets responsible for paclitaxel resistance in TNBC. Analysis of in vitro and in vivo data identified a set of genes that enhanced paclitaxel resistance in TNBC when functionally deleted. Some of these genes were found to act as negative regulators of cancer stemness. In vivo experiments confirmed that deletion of the FRG2 gene reduced paclitaxel efficacy and promoted tumor metastasis, while CRISPR activation of FRG2 increased sensitivity to paclitaxel and inhibited metastasis. This research highlights the potential of the FRG2 gene as a therapeutic target for overcoming paclitaxel resistance in TNBC.
Article
Oncology
Yiran Zhu, Bingluo Zhou, Xinyang Hu, Shilong Ying, Qiyin Zhou, Wenxia Xu, Lifeng Feng, Tianlun Hou, Xian Wang, Liyuan Zhu, Hongchuan Jin
Summary: This study reveals the role of LNC942 in promoting chemoresistance in gastric cancer (GC) and suggests that disrupting the LNC942-MSI2-c-Myc axis could be a potential therapeutic strategy for GC patients with chemoresistance.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jinglue Song, Xuening Dang, Xia Shen, Yun Liu, Jiani Gu, Xiang Peng, Zhenyu Huang, Wanjin Hong, Long Cui, Chen-Ying Liu
Summary: This study found that high nuclear expression of transcription factor TEAD4 is associated with lymph node metastasis and high lymphatic vessel density in patients with CRC. YAP/TAZ-TEAD4 complexes transcriptionally upregulated the expression of CCBE1 by directly binding to the enhancer region of CCBE1 in both CRC cells and cancer-associated fibroblasts, which resulted in enhanced VEGFC proteolysis and induced tube formation and migration of human lymphatic endothelial cells in vitro and lymphangiogenesis in a CRC cell-derived xenograft model in vivo. In addition, the bromodomain and extra-terminal domain (BET) inhibitor JQ1 significantly inhibited the transcription of CCBE1, suppressed VEGFC proteolysis, and inhibited tumor lymphangiogenesis in vitro and in vivo.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Oncology
Hyo-Jin Kim, Ki-Jun Ryu, Minju Kim, Taeyoung Kim, Seon-Hee Kim, Hyeontak Han, Hyemin Kim, Keun-Seok Hong, Chae Yeong Song, Yeonga Choi, Cheol Hwangbo, Kwang Dong Kim, Jiyun Yoo
Summary: This study identified the molecular mechanism by which RhoGDI2 promotes invasive ability of gastric cancer cells. RhoGDI2 increases Rac1 activity by recruiting Rac1 to Filamin A and enhancing the interaction between Rac1 and Trio. These findings suggest that RhoGDI2 may be a potential therapeutic target for reducing gastric cancer cell metastasis.
Article
Medicine, Research & Experimental
V. A. Subramanian, Ravindra Kumar Bairwa, Pradeep Kumar Sharma, Bhawana Bissa
Summary: This article discusses the roles of autophagy and exosomes in the cancer cell's adaptation to the tumor microenvironment and how the two pathways are coordinately regulated to facilitate cancer cell survival.
Article
Cell Biology
Hao Wu, Yijun Chu, Shanshan Sun, Guozheng Li, Shouping Xu, Xianyu Zhang, Yongdong Jiang, Song Gao, Qin Wang, Jian Zhang, Da Pang
Summary: This study found that hypoxia-induced HIF-1 alpha upregulated C1QBP, which when inhibited, notably blocked the metastasis of TNBC cells and increased their sensitivity to PTX under hypoxic conditions. Depletion of C1QBP decreased VCAM-1 expression by reducing the amount of P65 in the nucleus and suppressed the activation of hypoxia-induced PKC-NF-kappa B signaling. Targeting C1QBP along with PTX treatment could be a potential treatment for TNBC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Hannah G. McDonald, Megan M. Harper, Kristen Hill, Anqi Gao, Angelica L. Solomon, Charles J. Bailey, Miranda Lin, Mautin Barry-Hundeyin, Michael J. Cavnar, Samuel H. Mardini, Prakash J. Pandalai, Reema A. Patel, Jill M. Kolesar, Justin A. Rueckert, Lawrence Hookey, Mark Ropeleski, Shaila J. Merchant, Joseph Kim, Mei Gao
Summary: Gastric adenocarcinoma is a major cause of cancer-related deaths worldwide. We developed a novel methodology using patient-derived organoids (PDOs) to predict chemotherapy efficacy for these patients, which can help avoid unnecessary toxicities.
Article
Biochemistry & Molecular Biology
Wenjing Gong, Jianyuan Zeng, Jiafu Ji, Yongning Jia, Shuqin Jia, Andrew J. Sanders, Wen G. Jiang
Summary: EPLIN expression is associated with cancer progression and patient survival in gastric cancer. Lower EPLIN expression is linked to reduced overall survival and responsiveness to chemotherapy in NAC cohort.
Article
Oncology
Yuanyi Xu, Yuanyuan Yang, Yunning Huang, Qian Ma, Jing Shang, Jiaxin Guo, Xiangmei Cao, Xiaofei Wang, Mengqi Li
Summary: The Nrf2/HO-1 signaling pathway plays a positive regulatory role in angiogenesis in gastric cancer, while dextran sulfate (DS) suppresses angiogenesis by inhibiting this pathway.
Review
Cell Biology
Rachel Shi, Chengheng Liao, Qing Zhang
Summary: Hypoxia, a common feature of solid tumors, poses a challenge to the efficacy of conventional cancer treatments. The adaptive changes in cells under hypoxic conditions lead to survival, metastasis, and malignant phenotypes of tumors.
Review
Cell Biology
Sabreena Aashaq, Asiya Batool, Shabir Ahmad Mir, Mushtaq Ahmad Beigh, Khurshid Iqbal Andrabi, Zaffar Amin Shah
Summary: TGF-beta serves as a dual role in tumor progression, acting both as a tumor suppressor in the early stages and a metastatic promoter in the later stages. The signaling pathways of TGF-beta are complex, involving both SMAD-dependent and SMAD-independent pathways.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Oncology
Rong An, Yisong Wang, Donna Voeller, Arjan Gower, In-Kyu Kim, Yu-Wen Zhang, Giuseppe Giaccone
Article
Oncology
Guanhua Rao, In-Kyu Kim, Fabio Conforti, Jing Liu, Yu-Wen Zhang, Giuseppe Giaccone
EUROPEAN JOURNAL OF CANCER
(2018)
Article
Genetics & Heredity
Iacopo Petrini, Paul S. Meltzer, In-Kyu Kim, Marco Lucchi, Kang-Seo Park, Gabriella Fontanini, James Gao, Paolo A. Zucali, Fiorella Calabrese, Adolfo Favaretto, Federico Rea, Jaime Rodriguez-Canales, Robert L. Walker, Marbin Pineda, Yuelin J. Zhu, Christopher Lau, Keith J. Killian, Sven Bilke, Donna Voeller, Sivanesan Dakshanamurthy, Yisong Wang, Giuseppe Giaccone
Article
Biochemistry & Molecular Biology
In-Kyu Kim, Justine N. McCutcheon, Guanhua Rao, Stephen V. Liu, Yves Pommier, Marcin Skrzypski, Yu-Wen Zhang, Giuseppe Giaccone
Article
Multidisciplinary Sciences
Guanhua Rao, Mariaelena Pierobon, In-Kyu Kim, Wei-Hsun Hsu, Jianghong Deng, Yong-Wha Moon, Emanuel F. Petricoin, Yu-Wen Zhang, Yisong Wang, Giuseppe Giaccone
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Wei-Hsun Hsu, Xiaoliang Zhao, Jianquan Zhu, In-Kyu Kim, Guanhua Rao, Justine McCutcheon, Shuo-Tse Hsu, Beverly Teicher, Bhaskar Kallakury, Afshin Dowlati, Yu-Wen Zhang, Giuseppe Giaccone
JOURNAL OF THORACIC ONCOLOGY
(2019)
Article
Oncology
Sun-Mi Park, Seung-Ho Park, Ki-Jun Ryu, In-Kyu Kim, Hyeontak Han, Hyo-Jin Kim, Seon-Hee Kim, Keun-Seok Hong, Hyemin Kim, Minju Kim, Bok Im Cho, Jeong Doo Heo, Na Hyun Kim, Eun Mi Hwang, Jae-Yong Park, Jong In Yook, Hee Jun Cho, Cheol Hwangbo, Kwang Dong Kim, Hoseok Song, Jiyun Yoo
MOLECULAR ONCOLOGY
(2019)
Article
Oncology
Ki-Jun Ryu, Sun-Mi Park, Seung-Ho Park, In-Kyu Kim, Hyeontak Han, Hyo-Jin Kim, Seon-Hee Kim, Keun-Seok Hong, Hyemin Kim, Minju Kim, Sung-Jin Yoon, Killivalavan Asaithambi, Kon Ho Lee, Jae-Yong Park, Young-Sool Hah, Hee Jun Cho, Jong In Yook, Jung Wook Yang, Gyung-Hyuck Ko, Gyemin Lee, Yang Jae Kang, Cheol Hwangbo, Kwang Dong Kim, Young-Jun Park, Jiyun Yoo
Article
Biochemistry & Molecular Biology
In-Kyu Kim, Guanhua Rao, Xiaoliang Zhao, Ruzong Fan, Maria Laura Avantaggiati, Yisong Wang, Yu-Wen Zhang, Giuseppe Giaccone
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Oncology
Vincent Chen, Eiji Iwama, In-Kyu Kim, Giuseppe Giaccone
Article
Oncology
Shigeki Umemura, Jianquan Zhu, Joeffrey J. Chahine, Bhaskar Kallakury, Vincent Chen, In-Kyu Kim, Yu-Wen Zhang, Koichi Goto, Yongfeng He, Giuseppe Giaccone
Article
Endocrinology & Metabolism
Seonhyang Jeong, In-Kyu Kim, Hyunji Kim, Moon Jung Choi, Jandee Lee, Young Suk Jo
ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Oncology
Xiaoliang Zhao, In-Kyu Kim, Bhaskar Kallakury, Joeffrey J. Chahine, Eiji Iwama, Mariaelena Pierobon, Emanuel Petricoin, Justine N. McCutcheon, Yu-Wen Zhang, Shigeki Umemura, Vincent Chen, Changli Wang, Giuseppe Giaccone
Summary: Research demonstrates that the overexpression of Wee1 plays a crucial role in acquired resistance to Chk1 inhibition in SCLC, while bypass activation of the p38MAPK signaling pathway may also contribute to acquired resistance to Chk1 inhibition.
MOLECULAR ONCOLOGY
(2021)
Article
Oncology
Seonhyang Jeong, Seul-Gi Lee, Hyunji Kim, Gibbeum Lee, Sunmi Park, In-Kyu Kim, Jandee Lee, Young-Suk Jo
Summary: FAL1 upregulation has been reported in various types of human cancer, with a simultaneous upregulation adjacent to chromosome 1q21.3 identified using The Cancer Genome Atlas (TCGA) database. c-JUN and JUND were selected as master transcription factors for FAL1, and the molecular biological features represented RAS-driven papillary thyroid cancer (PTC). This simultaneous upregulation could potentially serve as a diagnostic and therapeutic target for RAS-driven PTC.
