Review
Hematology
Chen Wang, Jolan E. Walter
Summary: Immunodeficiency syndromes are a diverse group of genetic and acquired disorders characterized by various clinical manifestations. Autoantibodies, reflecting immune dysregulation, may contribute to certain clinical findings. The mechanism of autoantibody production in immunodeficiency is largely unknown, possibly influenced by genetic aberrations and infectious agents.
Review
Rheumatology
Mary K. Crow
Summary: Research has identified type I interferon (IFN-I) and autoantibodies targeting nucleic acids and nucleic acid-binding proteins as fundamental contributors to the pathogenesis of systemic lupus erythematosus (SLE). This review summarizes recent genetic analyses of SLE patients and current studies on innate and adaptive immune function, which contribute to sustained IFN-I pathway activation, immune activation, autoantibody production, inflammatory mediator generation, and tissue damage. The goal of these studies is to understand disease mechanisms, identify therapeutic targets, and develop better treatments for patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Julius Lindblom, Lorenzo Beretta, Maria Orietta Borghi, Marta E. Alarcon-Riquelme, Ioannis Parodis
Summary: The study identified CCL8, CXCL13, and IL-1RA as potential serum biomarkers for activity in SLE, correlating with SLE Disease Activity Index 2000 (SLEDAI-2K) scores. Autoantibodies showed similar occurrence across organ domains in SLE patients, with weak correlations to activity in different organ domains.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Robert M. Clancy, Miranda C. Marion, Hannah C. Ainsworth, Miao Chang, Timothy D. Howard, Peter M. Izmirly, Mala Masson, Jill P. Buyon, Carl D. Langefeld
Summary: This study investigates the relationship between the microbiome and anti-SSA/Ro antibodies, and how it affects disease state. Comparing the gut microbiome of healthy controls and anti-SSA/Ro positive women, differences in microbial relative abundances were found to be associated with clinical severity.
Article
Medicine, Research & Experimental
April P. De Silva, Mark A. Schembri, Angus H. Sarah, Jessica Chao, Kwok Ho Yip, Gokhan Cildir, Angel Lopez, Damon J. Tumes, Harshita Pant
Summary: Short-term oral prednisolone significantly improved symptoms and avoided surgical intervention in 52.5% of patients with chronic rhinosinusitis without nasal polyps within 12 months. Patients with symptom duration of less than 11 months were most likely to benefit.
Article
Rheumatology
Hiroyuki Nakamura, Tsutomu Tanaka, Thomas Pranzatelli, Youngmi Ji, Hongen Yin, Paola Perez, Sandra A. Afione, Shyh-Ing Jang, Corrine Goldsmith, Chang Yu Zheng, William D. Swaim, Blake M. Warner, Noriyuki Hirata, Masayuki Noguchi, Tatsuya Atsumi, John A. Chiorini
Summary: The study demonstrates that altering lysosome activity through the expression of LAMP3 in salivary gland epithelial cells can initiate an autoimmune response similar to SS, resulting in the production of autoantibodies and salivary dysfunction.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Medicine, General & Internal
Jakob Hjorth von Stemann, Ole Birger Vesterager Pedersen, Henrik Hjalgrim, Christian Erikstrup, Henrik Ullum, Joseph Dowsett, Lise Wegner Thorner, Margit Anita Horup Larsen, Erik Sorensen, Morten Bagge Hansen, Sisse Rye Ostrowski
Summary: This study is the first to suggest a potential influence of c-aAb on platelets in healthy individuals, beyond their apparent effects on immune competence.
FRONTIERS IN MEDICINE
(2022)
Article
Biology
Brendan Antiochos, Daniela Trejo-Zambrano, Paride Fenaroli, Avi Rosenberg, Alan Baer, Archit Garg, Jungsan Sohn, Jessica Li, Michelle Petri, Daniel W. Goldman, Christopher Mecoli, Livia Casciola-Rosen, Antony Rosen
Summary: This study suggests that extracellular ALRs bind NETs, leading to DNase resistant nucleoprotein fibers that are targeted as autoantigens in SLE.
Review
Hematology
Holger Winkels, Dennis Wolf
Summary: Atherosclerosis involves a partial autoimmune response with T cells recognizing and reacting to peptides from cholesterol particles. Recent research has revealed unexpected diversity among T cells, shedding light on their complex roles in atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Sarah Harden, Tse Yeun Tan, Chee Wai Ku, Jieliang Zhou, Qingfeng Chen, Jerry Kok Yen Chan, Jan Brosens, Yie Hou Lee
Summary: The objective of this study was to map the peritoneal autoantibody (AAb) landscape in women with endometriosis. The results showed that women with endometriosis had a higher number of AAbs, targeting autoantigens involved in implantation, B-cell activation/development, and aberrant migration and mitogenicity. Furthermore, specific AAbs, such as p53 AAbs, were associated with certain cellular pathways and infertility in endometriosis patients.
FERTILITY AND STERILITY
(2023)
Article
Rheumatology
May Yee Choi, Irene Chen, Ann Elaine Clarke, Marvin J. Fritzler, Katherine A. Buhler, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David Alan Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Kenneth Kalunian, Soren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Jill P. Buyon, David Sontag, Karen H. Costenbader
Summary: A novel longitudinal clustering technique was used to analyze comprehensive autoantibody data from a large, well-characterised, multinational inception SLE cohort, in order to determine predictive profiles of clinical outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Jean-Baptiste Vulsteke, Rita Derua, Sylvain Dubucquoi, Frederic Coutant, Sebastien Sanges, David Goncalves, Greet Wuyts, Petra De Haes, Daniel Blockmans, Wim A. Wuyts, Kristl G. Claeys, Ellen De Langhe, Nicole Fabien, Xavier Bossuyt
Summary: New and known antisynthetase autoantibodies (ASAs) were discovered and detected through protein immunoprecipitation combined with gel-free liquid chromatography-tandem mass spectrometry (IP-MS). The dominant cognate ARS autoantigen of the newly discovered anti-Ly ASA specificity was identified. Unbiased and targeted IP-MS are promising methods for discovery and detection of autoantibodies.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ana P. Lopes, Maarten R. Hillen, Anneline C. Hinrichs, Sofie Lm Blokland, Cornelis Pj Bekker, Aridaman Pandit, Aike A. Kruize, Timothy Rdj Radstake, Joel A. van Roon
Summary: This study reveals transcriptional alterations in pSS cDC2s, including changes in type I interferon, Toll-like receptor, antigen processing, and presentation pathways. These alterations lead to aberrant antigen uptake and processing by pSS cDC2s, as well as increased proliferation of tissue-homing CD4(+) T cells. These functional changes are strongly associated with anti-SSA positivity and the presence of type I interferons.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Immunology
Niels Hansen, Claudia Bartels, Bianca Teegen, Jens Wiltfang, Berend Malchow
Summary: This study provides evidence of an association between GAD65 autoantibodies in serum and cerebrospinal fluid and catatonia in patients with schizophrenia. Immunotherapy helped stabilize the catatonia symptoms in the patient. Further research is needed to investigate the response to treatment in a larger cohort of patients with GAD65 antibody-associated catatonia and schizophrenia.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Vanessa M. Beutgen, Norbert Pfeiffer, Franz H. Grus
Summary: This study revealed alterations in autoantibody levels in glaucoma patients and identified important subgroup predictors, enhancing prospective glaucoma subtype prediction. Furthermore, it provided insights into the characteristics of glaucoma-related antigens and their role in glaucoma pathogenesis, proposing new diagnostic approaches for glaucoma.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yi Qu, Jan Roger Olsen, Xing Yuan, Phil F. Cheng, Mitchell P. Levesque, Karl A. Brokstad, Paul S. Hoffman, Anne Margrete Oyan, Weidong Zhang, Karl-Henning Kalland, Xisong Ke
NATURE CHEMICAL BIOLOGY
(2018)
Article
Genetics & Heredity
He Li, Tove Ragna Reksten, John A. Ice, Jennifer A. Kelly, Indra Adrianto, Astrid Rasmussen, Shaofeng Wang, Bo He, Kiely M. Grundahl, Stuart B. Glenn, Corinne Miceli-Richard, Simon Bowman, Sue Lester, Per Eriksson, Maija-Leena Eloranta, Johan G. Brun, Lasse G. Goransson, Erna Harboe, Joel M. Guthridge, Kenneth M. Kaufman, Marika Kvarnstrom, Deborah S. Cunninghame Graham, Ketan Patel, Adam J. Adler, A. Darise Farris, Michael T. Brennan, James Chodosh, Rajaram Gopalakrishnan, Michael H. Weisman, Swamy Venuturupalli, Daniel J. Wallace, Kimberly S. Hefner, Glen D. Houston, Andrew J. W. Huang, Pamela J. Hughes, David M. Lewis, Lida Radfar, Evan S. Vista, Contessa E. Edgar, Michael D. Rohrer, Donald U. Stone, Timothy J. Vyse, John B. Harley, Patrick M. Gaffney, Judith A. James, Sean Turner, Ilias Alevizos, Juan-Manuel Anaya, Nelson L. Rhodus, Barbara M. Segal, Courtney G. Montgomery, R. Hal Scofield, Susan Kovats, Xavier Mariette, Lars Ronnblom, Torsten Witte, Maureen Rischmueller, Marie Wahren-Herlenius, Roald Omdal, Roland Jonsson, Wan-Fai Ng, Gunnel Nordmark, Christopher J. Lessard, Kathy L. Sivils
Article
Immunology
K. A. Brokstad, M. Fredriksen, F. Zhou, B. Bergum, J. G. Brun, R. J. Cox, K. Skarstein
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Roland Jonsson, Karl A. Brokstad, Malin V. Jonsson, Nicolas Delaleu, Kathrine Skarstein
EUROPEAN JOURNAL OF ORAL SCIENCES
(2018)
Article
Nutrition & Dietetics
Ida Heir Hovland, Ingrid Sande Leikanger, Oddbjorg Stokkeland, Kaia Hevroy Waage, Svein A. Mjos, Karl A. Brokstad, Adrian McCann, Per Magne Ueland, Rasa Slizyte, Ana Carvajal, Gunnar Mellgren, Tore Remman, Ingmar Hogoy, Oddrun A. Gudbrandsen
EUROPEAN JOURNAL OF NUTRITION
(2020)
Article
Immunology
Sarah Lartey, Fan Zhou, Karl A. Brokstad, Kristin G- Mohn, Steffen A. Slettevoll, Rishi D. Pathirana, Rebecca J. Cox
JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Immunology
Shahinul Islam, Fan Zhou, Sarah Lartey, Kristin G. I. Mohn, Florian Krammer, Rebecca Jane Cox, Karl Albert Brokstad
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Rheumatology
Albin Bjork, Gudny Ella Thorlacius, Johannes Mofors, Elina Richardsdotter Andersson, Margarita Ivanchenko, Joanna Tingstrom, Tojo James, Karl A. Brokstad, Rebecca J. Cox, Roland Jonsson, Marika Kvarnstrom, Marie Wahren-Herlenius
Article
Virology
Nina Urke Ertesvag, Sunniva Todnem Sakkestad, Fan Zhou, Ingrid Hoff, Trygve Kristiansen, Trygve Muller Jonassen, Elisabeth Folleso, Karl Albert Brokstad, Ruben Dyrhovden, Kristin G. I. Mohn
Summary: Persistent fever after SARS-CoV-2 infection in rituximab-treated patients is challenging to differentiate between low-grade viral replication or hyperinflammation due to reduced sensitivity in conventional sampling methods and unspecific symptoms. In this case report, a multiple sclerosis patient receiving B cell depletion therapy experienced 96 days of persistent fever and SARS-CoV-2 infection. Migratory lung infiltrates and positive PCR tests confirmed continuous viral replication in serum and lower airways. The dominant symptoms were continuous high fever, dyspnea, and mild to moderate hypoxemia.
Article
Multidisciplinary Sciences
Bhuwan Khatri, Kandice L. Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam Adler, Ilias Alevizos, Juan-Manuel Anaya, Lara A. Aqrawi, Eva Baecklund, Johan G. Brun, Sara Magnusson Bucher, Maija-Leena Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart B. Glenn, Daniel Hammenfors, Juliana Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglaend Johnsen, Malin Jonsson, Marika Kvarnstrom, Jennifer A. Kelly, He Li, Thomas Mandl, Javier Martin, Gaetane Nocturne, Katrine Braekke Norheim, Oyvind Palm, Kathrine Skarstein, Anna M. Stolarczyk, Kimberly E. Taylor, Maria Teruel, Elke Theander, Swamy Venuturupalli, Daniel J. Wallace, Kiely M. Grundahl, Kimberly S. Hefner, Lida Radfar, David M. Lewis, Donald U. Stone, C. Erick Kaufman, Michael T. Brennan, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Patrick M. Gaffney, Lindsey A. Criswell, Roland Jonsson, Per Eriksson, Simon J. Bowman, Roald Omdal, Lars Ronnblom, Blake Warner, Maureen Rischmueller, Torsten Witte, A. Darise Farris, Xavier Mariette, Marta E. Alarcon-Riquelme, Caroline H. Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy L. Sivils, Indra Adrianto, Gunnel Nordmark, Christopher J. Lessard
Summary: This study identifies ten novel genetic risk regions associated with Sjogren's disease, implicating genes involved in immune and salivary gland function.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Nina Urke Ertesvag, Rebecca Jane Cox, Sarah Larteley Lartey, Kristin G- Mohn, Karl Albert Brokstad, Mai-Chi Trieu
Summary: This study investigated the breadth and durability of influenza A/H3N2-specific antibodies in children and adults. It found that childhood infection increased adult antibody responses, and repeatedly vaccinated adults had broader and more durable antibodies.
Correction
Multidisciplinary Sciences
Bhuwan Khatri, Kandice L. Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam Adler, Ilias Alevizos, Juan-Manuel Anaya, Lara A. Aqrawi, Eva Baecklund, Johan G. Brun, Sara Magnusson Bucher, Maija-Leena Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart B. Glenn, Daniel Hammenfors, Juliana Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglaend Johnsen, Malin V. Jonsson, Marika Kvarnstrom, Jennifer A. Kelly, He Li, Thomas Mandl, Javier Martin, Gaetane Nocturne, Katrine Braekke Norheim, Oyvind Palm, Kathrine Skarstein, Anna M. Stolarczyk, Kimberly E. Taylor, Maria Teruel, Elke Theander, Swamy Venuturupalli, Daniel J. Wallace, Kiely M. Grundahl, Kimberly S. Hefner, Lida Radfar, David M. Lewis, Donald U. Stone, C. Erick Kaufman, Michael T. Brennan, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Patrick M. Gaffney, Lindsey A. Criswell, Roland Jonsson, Per Eriksson, Simon J. Bowman, Roald Omdal, Lars Ronnblom, Blake Warner, Maureen Rischmueller, Torsten Witte, A. Darise Farris, Xavier Mariette, Marta E. Alarcon-Riquelme, Caroline H. Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy L. Sivils, Indra Adrianto, Gunnel Nordmark, Christopher J. Lessard
NATURE COMMUNICATIONS
(2022)
Correction
Multidisciplinary Sciences
Bhuwan Khatri, Kandice Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam A. Adler, Ilias Alevizos, Juan-Manuel G. Anaya, Lara Aqrawi, Eva Baecklund, Johan Brun, Sara Magnusson Bucher, Maija-Leena B. Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart Glenn, Daniel Hammenfors, Juliana V. Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglaend A. Johnsen, Malin Jonsson, Marika Kvarnstroem, Jennifer Kelly, He Li, Thomas Mandl, Javier Martin, Gaetane Nocturne, Katrine Braekke M. Norheim, Oyvind E. Palm, Kathrine Skarstein, Anna Stolarczyk, Kimberly Taylor, Maria J. Teruel, Elke M. Theander, Swamy S. Venuturupalli, Daniel Wallace, Kiely M. Grundahl, Kimberly U. Hefner, Lida Radfar, David T. Lewis, Donald M. Stone, C. Erick A. Kaufman, Michael Brennan, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Patrick Gaffney, Lindsey J. Criswell, Roland Jonsson, Per Eriksson, Simon Bowman, Roald Omdal, Lars Roennblom, Blake Warner, Maureen Rischmueller, Torsten E. Witte, A. Darise H. Farris, Xavier Mariette, Marta Alarcon-Riquelme, Caroline L. Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy J. Sivils, Indra Adrianto, Gunnel Nordmark, Christopher Lessard
NATURE COMMUNICATIONS
(2023)
Article
Health Care Sciences & Services
Hans-Georg Eichler, Roisin Adams, Einar Andreassen, Peter Arlett, Marc van de Casteele, Suzannah J. Chapman, Wim G. Goettsch, Jonathan Lind Martinsson, Jordi Llinares-Garcia, Anna Nachtnebel, Elias Pean, Guido Rasi, Tove Ragna Reksten, Lonneke Timmers, Rick A. Vreman, Inneke van de Vijver, Martin Wenzl
Summary: The study examined the potential improvement of feasibility of PB-MEAs by aligning regulatory post-authorization requirements and active collaboration. Reviewers found that regulatory post-authorization studies could partly help implement PB-MEAs, but recognized obstacles such as insufficient public information and complexities in implementation. Despite PB-MEAs not being the preferred option for CAPRs, there was seen as potential for their implementation or collaboration across CAPRs.
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE
(2021)
Article
Medicine, General & Internal
Ellen Johanne Vara, Karl A. Brokstad, Trygve Hausken, Gulen Arslan Lied
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2018)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)