Deciphering the role of cDC2s in Sjögren’s syndrome: transcriptomic profile links altered antigen processes with IFN signature and autoimmunity

Sjögren’s and non-Sjögren’s sicca share a similar symptom burden but with a distinct symptom-associated proteomic signature

(2022) Valentina Pucino et al.   RMD Open

Predicted Disease-Specific Immune Infiltration Patterns Decode the Potential Mechanisms of Long Non-Coding RNAs in Primary Sjogren’s Syndrome

(2021) Caiqi Cheng et al.   Frontiers in Immunology

The Transcriptomic Profile of Monocytes from Patients With Sjögren’s Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators

(2021) Ana P. Lopes et al.   Frontiers in Immunology

LAMP3 induces apoptosis and autoantigen release in Sjögren’s syndrome patients

(2020) Tsutomu Tanaka et al.   Scientific Reports

Epigenetically quantified immune cells in salivary glands of Sjögren’s syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopathology

(2019) Sofie L.M. Blokland et al.   RHEUMATOLOGY

MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sjögren's Syndrome by Targeting Mitogen- and Stress-Activated Protein Kinase-1

(2019) Ana P. Lopes et al.   Frontiers in Immunology

Plasmacytoid DCs From Patients With Sjögren's Syndrome Are Transcriptionally Primed for Enhanced Pro-inflammatory Cytokine Production

(2019) Maarten R. Hillen et al.   Frontiers in Immunology

Diminished CXCR5 expression in peripheral blood of patients with Sjögren's syndrome may relate to both genotype and salivary gland homing

(2018) L. A. Aqrawi et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Disruption of CXCR3 function impedes the development of Sjögren’s syndrome-like xerostomia in non-obese diabetic mice

(2018) Jing Zhou et al.   LABORATORY INVESTIGATION

Circulating small non-coding RNAs reflect IFN status and B cell hyperactivity in patients with primary Sjögren’s syndrome

(2018) Ana P. Lopes et al.   PLoS One

Systemic interferon type I and type II signatures in primary Sjögren’s syndrome reveal differences in biological disease activity

(2018) Iris L A Bodewes et al.   RHEUMATOLOGY

Interferons and Dry Eye in Sjögren’s Syndrome

(2018) Yoko Ogawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human Blood CD1c+Dendritic Cells Encompass CD5highand CD5lowSubsets That Differ Significantly in Phenotype, Gene Expression, and Functions

(2017) Xiangyun Yin et al.   JOURNAL OF IMMUNOLOGY

Control of gene expression through the nonsense-mediated RNA decay pathway

(2017) Andrew Nickless et al.   Cell and Bioscience

Cytometry by time-of-flight immunophenotyping identifies a blood Sjögren's signature correlating with disease activity and glandular inflammation

(2016) Michael Mingueneau et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Sjögren syndrome

(2016) Pilar Brito-Zerón et al.   Nature Reviews Disease Primers

Endoplasmic reticulum stress causes autophagy and apoptosis leading to cellular redistribution of the autoantigens Ro/Sjögren's syndrome-related antigen A (SSA) and La/SSB in salivary gland epithelial cells

(2015) S. Katsiougiannis et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Fractalkine–CX3CR1-dependent recruitment and retention of human CD1c+ myeloid dendritic cells by in vitro–activated proximal tubular epithelial cells

(2015) Andrew J. Kassianos et al.   KIDNEY INTERNATIONAL

Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets

(2015) Enric Gutiérrez-Martínez   Frontiers in Immunology

Phagocytosis of apoptotic or necrotic cells differentially regulates the transcriptional expression of IL-12 family members in dendritic cells

(2014) K. O. Dixon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

β2integrins inhibit TLR responses by regulating NF-κB pathway and p38 MAPK activation

(2013) Nathan K. Yee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CX3CL1 and CX3CR1 expression in tertiary lymphoid structures in salivary gland infiltrates: fractalkine contribution to lymphoid neogenesis in Sjogren's syndrome

(2013) E. Astorri et al.   RHEUMATOLOGY

Prevalence of interferon type I signature in CD14 monocytes of patients with Sjögren's syndrome and association with disease activity and BAFF gene expression

(2012) Zana Brkic et al.   ANNALS OF THE RHEUMATIC DISEASES

Influence of Dendritic Cells on B-Cell Responses during HIV Infection

(2012) Johanne Poudrier et al.   Clinical & Developmental Immunology

Plexin-B2 and Plexin-D1 in Dendritic Cells: Expression and IL-12/IL-23p40 Production

(2012) Eda K. Holl et al.   PLoS One

The Role of Insulin-Regulated Aminopeptidase in MHC Class I Antigen Presentation

(2012) Loredana Saveanu et al.   Frontiers in Immunology

IFN-  enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing

(2011) F. Spadaro et al.   BLOOD

CXCR5 Expressing Human Central Memory CD4 T Cells and Their Relevance for Humoral Immune Responses

(2011) N. Chevalier et al.   JOURNAL OF IMMUNOLOGY

LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming

(2010) S. Balkow et al.   BLOOD

The role of dendritic cells in the pathogenesis of systemic lupus erythematosus

(2010) Justin H Fransen et al.   ARTHRITIS RESEARCH & THERAPY

Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17

(2009) Justin H. Fransen et al.   ARTHRITIS AND RHEUMATISM

LOX-1 as a natural IFN- -mediated signal for apoptotic cell uptake and antigen presentation in dendritic cells

(2009) S. Parlato et al.   BLOOD

Dendritic cells require a systemic type I interferon response to mature and induce CD4+Th1 immunity with poly IC as adjuvant

(2009) M. Paula Longhi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity

(2009) N. van Montfoort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRAP Identifies an Endosomal Compartment Required for MHC Class I Cross-Presentation

(2009) L. Saveanu et al.   SCIENCE

Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells

(2008) Noriyuki Fujikado et al.   NATURE MEDICINE