The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps

Bite of the wolf: innate immune responses propagate autoimmunity in lupus

(2021) Sarthak Gupta et al.   JOURNAL OF CLINICAL INVESTIGATION

The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps

(2021) Falko Apel et al.   Science Signaling

Distinct axial and lateral interactions within homologous filaments dictate the signaling specificity and order of the AIM2-ASC inflammasome

(2021) Mariusz Matyszewski et al.   Nature Communications

Toll-like receptor 4-mediated inflammation triggered by extracellular IFI16 is enhanced by lipopolysaccharide binding

(2020) Andrea Iannucci et al.   PLoS Pathogens

Lupus nephritis: clinical presentations and outcomes in the 21st century

(2020) Michela Gasparotto et al.   RHEUMATOLOGY

Neutrophil Extracellular Traps protein composition is specific for patients with Lupus nephritis and includes methyl-oxidized αenolase (methionine sulfoxide 93)

(2019) Maurizio Bruschi et al.   Scientific Reports

Sources of Pathogenic Nucleic Acids in Systemic Lupus Erythematosus

(2019) Tomas Mustelin et al.   Frontiers in Immunology

Neutrophil Extracellular Traps in the Establishment and Progression of Renal Diseases

(2019) Hector Salazar-Gonzalez et al.   Medicina-Lithuania

NETosis, complement, and coagulation: a triangular relationship

(2018) Cynthia M. de Bont et al.   Cellular & Molecular Immunology

Netting Neutrophils Activate Autoreactive B Cells in Lupus

(2018) Nicolas Gestermann et al.   JOURNAL OF IMMUNOLOGY

Cervical cancer is addicted to SIRT1 disarming the AIM2 antiviral defense

(2018) Daeho So et al.   ONCOGENE

Digital signaling network drives the assembly of the AIM2-ASC inflammasome

(2018) Mariusz Matyszewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A)

(2018) Eleni Frangou et al.   ANNALS OF THE RHEUMATIC DISEASES

Autoantigens as Partners in Initiation and Propagation of Autoimmune Rheumatic Diseases

(2016) Antony Rosen et al.   Annual Review of Immunology

The role of neutrophils and NETosis in autoimmune and renal diseases

(2016) Sarthak Gupta et al.   Nature Reviews Nephrology

Association of Antibodies to Interferon-Inducible Protein-16 With Markers of More Severe Disease in Primary Sjögren's Syndrome

(2016) Alan N. Baer et al.   ARTHRITIS CARE & RESEARCH

2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren's Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts

(2016) Caroline H. Shiboski et al.   Arthritis & Rheumatology

Clearance Deficiency and Cell Death Pathways: A Model for the Pathogenesis of SLE

(2016) Aparna Mahajan et al.   Frontiers in Immunology

The Extracellular IFI16 Protein Propagates Inflammation in Endothelial Cells Via p38 MAPK and NF-κB p65 Activation

(2015) Mandar Bawadekar et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC

(2015) Seamus R. Morrone et al.   Nature Communications

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

Nuclear DNA Sensor IFI16 as Circulating Protein in Autoimmune Diseases Is a Signal of Damage that Impairs Endothelial Cells through High-Affinity Membrane Binding

(2013) Francesca Gugliesi et al.   PLoS One

Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy

(2013) S. R. Morrone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The rheumatoid arthritis synovial fluid citrullinome reveals novel citrullinated epitopes in apolipoprotein E, myeloid nuclear differentiation antigen, and β-actin

(2012) Joyce J. B. C. van Beers et al.   ARTHRITIS AND RHEUMATISM

Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus

(2012) Michelle Petri et al.   ARTHRITIS AND RHEUMATISM

Type I interferons in Sjögren's syndrome

(2012) Yihong Yao et al.   AUTOIMMUNITY REVIEWS

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

(2011) G. S. Garcia-Romo et al.   Science Translational Medicine

Redistribution of the nuclear protein IFI16 into the cytoplasm of ultraviolet B-exposed keratinocytes as a mechanism of autoantigen processing

(2010) S. Costa et al.   BRITISH JOURNAL OF DERMATOLOGY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

DNase 1 and systemic lupus erythematosus

(2008) Fernando Martínez Valle et al.   AUTOIMMUNITY REVIEWS