Anti-HMGB1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma: Attenuated T-Lymphocyte Response and Increased Splenic CD11b+Gr-1+Myeloid-Derived Suppressor Cells Require HMGB1

HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines

(2014) Y. Sha et al.   JOURNAL OF IMMUNOLOGY

Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells

(2014) P. Sinha et al.   JOURNAL OF IMMUNOLOGY

The Central Role of Arginine Catabolism in T-Cell Dysfunction and Increased Susceptibility to Infection After Physical Injury

(2013) Xinmei Zhu et al.   ANNALS OF SURGERY

HMGB1 recruits myeloid derived suppressor cells to promote peritoneal dissemination of colon cancer after resection

(2013) Wei Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification and Description of a Novel Murine Model for Polytrauma and Shock

(2013) Lori F. Gentile et al.   CRITICAL CARE MEDICINE

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Selective roles for toll-like receptors 2, 4, and 9 in systemic inflammation and immune dysfunction following peripheral tissue injury

(2013) Sophie S. Darwiche et al.   Journal of Trauma and Acute Care Surgery

Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma

(2013) Erin L. Vanzant et al.   Journal of Trauma and Acute Care Surgery

Up-regulation of mitofusin-2 protects CD4+ T cells from HMGB1-mediated immune dysfunction partly through Ca2+-NFAT signaling pathway

(2012) Guang-ju Zhao et al.   CYTOKINE

Trauma equals danger--damage control by the immune system

(2012) V. M. Stoecklein et al.   JOURNAL OF LEUKOCYTE BIOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Inducible Nitric Oxide Synthase Contributes to Immune Dysfunction Following Trauma

(2012) Sophie S. Darwiche et al.   SHOCK

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Heat shock proteins and high mobility group box 1 protein lack cytokine function

(2011) Min-Fu Tsan   JOURNAL OF LEUKOCYTE BIOLOGY

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(2011) Alex Cuenca et al.   MOLECULAR MEDICINE

Interleukin-6 Induces Gr-1+CD11b+ Myeloid Cells to Suppress CD8+ T Cell-Mediated Liver Injury in Mice

(2011) Liang Cheng et al.   PLoS One

Pseudofracture: An Acute Peripheral Tissue Trauma Model

(2011) Sophie S. Darwiche et al.   Jove-Journal of Visualized Experiments

Divergent adaptive and innate immunological responses are observed in humans following blunt trauma

(2010) Kevin R Kasten et al.   BMC IMMUNOLOGY

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function

(2010) Leif E. Sander et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Characterization of Cytokine-Induced Myeloid-Derived Suppressor Cells from Normal Human Peripheral Blood Mononuclear Cells

(2010) M. G. Lechner et al.   JOURNAL OF IMMUNOLOGY

Role of hemorrhage in the induction of systemic inflammation and remote organ damage: Analysis of combined pseudo-fracture and hemorrhagic shock

(2010) Roman Pfeifer et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Models of Lower Extremity Damage in Mice: Time Course of Organ Damage and Immune Response

(2010) Christoph L. Menzel et al.   JOURNAL OF SURGICAL RESEARCH

Suppression of Activation and Costimulatory Signaling in Splenic CD4 + T Cells after Trauma-Hemorrhage Reduces T-Cell Function

(2009) Chi-Hsun Hsieh et al.   AMERICAN JOURNAL OF PATHOLOGY

Stat 6-Dependent Induction of Myeloid Derived Suppressor Cells After Physical Injury Regulates Nitric Oxide Response to Endotoxin

(2009) Veronica Munera et al.   ANNALS OF SURGERY

Immune Stimulatory Receptor CD40 Is Required for T-Cell Suppression and T Regulatory Cell Activation Mediated by Myeloid-Derived Suppressor Cells in Cancer

(2009) P.-Y. Pan et al.   CANCER RESEARCH

HMGB1 Enhances the Proinflammatory Activity of Lipopolysaccharide by Promoting the Phosphorylation of MAPK p38 through Receptor for Advanced Glycation End Products

(2009) Y.-H. Qin et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

(2009) S. Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation

(2009) Hulda Sigridur Hreggvidsdottir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HMGB1 IS MARKEDLY ELEVATED WITHIN 6 HOURS OF MECHANICAL TRAUMA IN HUMANS

(2009) Erik D. Peltz et al.   SHOCK

Invited review: Deterioration of the immune system after trauma: signals and cellular mechanisms

(2008) Stefanie B. Flohé et al.   Innate Immunity

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(2008) Raghavan Raju et al.   MOLECULAR MEDICINE