Article
Multidisciplinary Sciences
Peng Wang, Li-Na Jiang, Chen Wang, Ying Li, Meng Yin, Hui-Bo Du, Hong Zhang, Ze-Hua Fan, Yan-Xu Liu, Meng Zhao, An-Ling Kang, Ding-Ya Feng, Shu-Guang Li, Chun-Yu Niu, Zi-Gang Zhao
Summary: The study found that estrogen has beneficial effects on CD4+T lymphocytes function, mediated by ER-alpha and GPR30, which can attenuate endoplasmic reticulum stress induced by hemorrhagic shock.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Theodora Anagnostou, Zhi-Zhang Yang, Shahrzad Jalali, Hyo Jin Kim, Daniel P. Larson, Xinyi Tang, Yue Yu, Joshua C. Pritchett, Jose Villasboas Bisneto, Tammy L. Price-Troska, Patrizia Mondello, Anne J. Novak, Stephen M. Ansell
Summary: In this study, the tumor microenvironment (TME) and intratumoral T cells in splenic marginal zone lymphoma (sMZL) were investigated using single cell analysis. The TME in sMZL differed from non-malignant reactive spleen. T-FH cells were found to be more abundant in sMZL and positively correlated with memory B cells. T-reg cells, particularly TIGIT(+) T-reg cells, were enriched in sMZL and associated with the suppression of T(H)17 and T(H)22 cells. CD8(+) T cells within the tumor exhibited functional impairment due to subsets of short-lived, exhausted, and late-stage differentiated cells. Immune exhaustion was present in sMZL, and TIM-3 expression on PD-1(low) cells indicated severe immune dysfunction. Gene expression profiling validated these findings.
Article
Immunology
Yiqun Geng, Zhihao Lu, Jitian Guan, Nico van Rooijen, Ye Zhi
Summary: Inflammation after acute CNS injury involves a complex interaction between microglia/macrophages and CD4(+)CD25(+) T cells, with the former promoting neuroprotection by secreting cytokines to suppress T cell-mediated cytotoxicity on injured neurons.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Ashley E. Walker, Jazmin A. Cole, Sahana Krishna Kumaran, Jonathan I. Kato, Xinhao Zhuang, Julia R. Wolf, Grant D. Henson, Belinda H. McCully
Summary: Obesity increases the risk of complications and mortality after trauma, which are associated with vascular damage. The impact of obesity on vascular dysfunction after traumatic hemorrhage is unclear. This study suggests that obesity may potentiate trauma-induced vascular inflammation and dysfunction.
Article
Immunology
Deyuan Chen, Ke Li, Liuhua Pan, Yueming Wu, Miaomiao Chen, Xian Zhang, Junlong Xu, Tianzheng Lou
Summary: This study found that downregulation of TCF7 and LEF-1 expression in sepsis inhibited the proliferation of CD4(+) T cells, leading to immune suppression. It suggests that TCF7 and LEF-1 could be potential therapeutic targets for sepsis, and improving CD4(+) T cell proliferation may be a new strategy for sepsis treatment.
MICROBIAL PATHOGENESIS
(2023)
Review
Medicine, General & Internal
Myoung Soo Kim, Younghwan Kim
Summary: Hematomas caused by the rupture of a pseudoaneurysm in the middle meningeal artery (MMA) after trauma usually present as epidural hematomas. Intracerebral hemorrhage (ICH) is extremely rare. We reviewed ICH due to the rupture of MMA pseudoaneurysms and found that in cases of acute ICH, the pseudoaneurysm was attached to the outer surface of the dura mater and associated with dura tear. In patients with delayed ICH, the pseudoaneurysms adhered to the inner surface of the dura mater. Rupture of pseudoaneurysms might lead to ICH through dura tear after trauma.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Juliana Trindade Clemente-Napimoga, Vagner Mendes, Carlos Antonio Trindade-da-Silva, Gustavo de Carvalho, Aletheia Caldeira Goncalves Alcantara Paranhos, Frederico Andrade e Silva, Wilkens Aurelio Buarque e Silva, Marcelo Henrique Napimoga, Henrique Ballassini Abdalla
Summary: We investigated the activation of satellite glial cells (SGCs) in the trigeminal ganglion (TG) following experimental traumatic occlusion (ETO). We found overexpression of GFAP and activation of SGCs in TG after ETO. Additionally, ETO groups showed upregulation of purinergic signaling and the CX3CL1/CX3CR1 axis. We also observed the involvement of resident and infiltrating cells, such as macrophages, in ETO and the induction of chronic immune response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Baibing Yang, Joy M. Davis, Thomas H. Gomez, Mamoun Younes, Xiurong Zhao, Qiang Shen, Run Wang, Tien C. Ko, Yanna Cao
Summary: This study investigated immune cell infiltration patterns in different experimental acute pancreatitis mouse models and found variations in immune responses based on different treatment methods. Computerized analysis proved to be more efficient and reproducible in analyzing immune cells compared to manual gating analysis.
CELL AND BIOSCIENCE
(2021)
Article
Surgery
Puja D. Patel, Mark Broadwin, Tara Stansbury, Jeffrey B. Brown, Hope Kincaid, Shae Duka, Justin Pasquale, Mark Cipolle, Kamalesh Shah
Summary: Community centers often transfer patients with traumatic intracranial hemorrhage (ICH) to higher-level trauma centers for neurosurgical evaluation, regardless of the severity of the injury. Identifying risk factors associated with neurosurgical intervention (NSI) may help reduce morbidity and mortality of traumatic ICH and unnecessary transfers. This retrospective study found that male gender, warfarin use, subdural hemorrhage, larger subdural hemorrhage size, worsening repeat head CT scan, confusion, hemiparesis, midline shift, and shift size were significantly associated with NSI. These clinical factors and patient characteristics can help predict the likelihood of requiring NSI and facilitate appropriate transfers.
JOURNAL OF SURGICAL RESEARCH
(2023)
Review
Immunology
Jessica Katy Skelton, Robert Purcell
Summary: Traumatic injury triggers a complex immune response that can lead to complications such as sepsis and multiple organ dysfunction syndrome. Understanding immune responses to trauma is crucial for improving patient outcomes, but animal models are limited in their ability to mimic human immune function.
Article
Biology
Wei Wei, Yanjun Su
Summary: In this study, researchers used single cell sequencing technology to investigate T cells in non-small-cell lung cancer patients, identifying specific genes related to immune cell function and inferring the function of three types of T cells. The application of this technology helps to understand the mechanism of lung cancer occurrence and development, discover new diagnostic markers and therapeutic targets, and provide a theoretical reference for precise treatment of lung cancer patients in the future.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Oncology
Hiroyoshi Nishikawa, Shohei Koyama
Summary: With the widespread use of immunotherapies in cancer treatment, understanding the immune landscape in the tumor microenvironment has become crucial. Regulatory T cells (Tregs) play a key role in cancer immunity but also contribute to immune evasion by tumor cells. Targeting Tregs is considered a crucial aspect of cancer immunotherapy, especially in tumors with abundant Treg presence.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Psychology, Clinical
Mohith M. Varma, Xiaoqing Hu
Summary: This study investigates whether post-trauma prosocial behavior can reduce trauma-related symptoms. The results show that engaging in prosocial behavior, such as donating to charity, can reduce involuntary traumatic intrusions. The effects of reduced intrusions were observed in both laboratory settings and daily life. Enhanced positive affect may partly explain the reduction in intrusions.
BEHAVIOUR RESEARCH AND THERAPY
(2022)
Article
Cell Biology
Jie Qu, Hang-Fan Zong, Yi Shan, Shan-Chun Zhang, Wei-Ping Guan, Yang Yang, Heng-Li Zhao
Summary: By inhibiting Piezo1, brain edema, myelin sheath loss, and degeneration can be alleviated, oligodendrocyte apoptosis can be reduced, and neurological function can be significantly improved, making it a potential therapeutic target for intracerebral hemorrhage.
NEURAL REGENERATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Samuel X. Shi, Yuwen Xiu, Yan Li, Meng Yuan, Kaibin Shi, Qiang Liu, Xiaoying Wang, Wei-Na Jin
Summary: Leukocyte infiltration exacerbates brain injury after intracerebral hemorrhage (ICH), and CD4+ T cells are found to accumulate in the perihematomal regions, playing a role in the development of perihematomal edema (PHE). These T cells disrupt blood-brain barrier integrity and promote PHE progression through interleukin-17 release and engagement of DR5 to trigger endothelial death.
Review
Biochemistry & Molecular Biology
Ninu Poulose, Raghavan Raju
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2015)
Article
Biochemistry & Molecular Biology
Ahmar Ayub, Ninu Poulose, Raghavan Raju
MOLECULAR MEDICINE
(2015)
Article
Biochemistry & Molecular Biology
Sumin Lu, Alex Aguilar, Kumar Subramani, Ninu Poulose, Ahmar Ayub, Raghavan Raju
Article
Neurosciences
P. Benson Ham, Raghavan Raju
PROGRESS IN NEUROBIOLOGY
(2017)
Article
Multidisciplinary Sciences
Kumar Subramani, Sumin Lu, Marie Warren, Xiaogang Chu, Haroldo A. Toque, R. William Caldwell, Michael P. Diamond, Raghavan Raju
SCIENTIFIC REPORTS
(2017)
Article
Urology & Nephrology
Nino Kvirkvelia, Malgorzata McMenamin, Marie Warren, Ravirajsinh N. Jadeja, Sai Karthik Kodeboyina, Ashok Sharma, Wenbo Zhi, Paul M. O'Connor, Raghavan Raju, Rudolf Lucas, Michael P. Madaio
KIDNEY INTERNATIONAL
(2018)
Article
Biochemistry & Molecular Biology
Bixi Jian, Shaolong Yang, Irshad H. Chaudry, Raghavan Raju
MOLECULAR MEDICINE
(2014)
Article
Multidisciplinary Sciences
Marlene E. Starr, Allison M. Steele, Mizuki Saito, Bill J. Hacker, B. Mark Evers, Hiroshi Saito
Article
Immunology
Kumar Subramani, Srikrishnan P. Raju, Xiaogang Chu, Marie Warren, Chirayu D. Pandya, Nasrul Hoda, Sadanand Fulzele, Raghavan Raju
INTERNATIONAL IMMUNOPHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Kumar Subramani, Xiaogang Chu, Marie Warren, Mariah Lee, Sumin Lu, Nagendra Singh, Raghavan Raju
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2019)
Article
Cell Biology
Xiaogang Chu, Jin Wen, Raghavan Pillai Raju
Article
Neurosciences
Raghavan Pillai Raju, Lun Cai, Alpna Tyagi, Subbiah Pugazhenthi
Summary: In this study, using RNA-seq analysis, we found significant changes in gene expression related to pathways including oxidation-reduction, oxidative phosphorylation, innate immune response, ribosomal protein synthesis, and ubiquitin proteosome system in the brains of 5XFAD mice. The downregulation of genes related to oxidation-reduction and upregulation of immune response genes were the most striking features observed. Gene interaction analysis revealed at least three distinct interaction clusters, with the predominant one relating to cellular energetics.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marie Warren, Kumar Subramani, Richard Schwartz, Raghavan Raju
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2017)
Review
Geriatrics & Gerontology
Ninu Poulose, Raghavan Raju
Article
Geriatrics & Gerontology
Chandrasekharam N. Nagineni, Raghavan Raju, Krishnasai K. Nagineni, Vijay K. Kommineni, Aswini Cherukuri, R. Krishnan Kutty, John J. Hooks, Barbara Detrick