Interleukin 23 in Crohnʼs Disease

Cutting Edge: NKT Cells Constitutively Express IL-23 Receptor and ROR t and Rapidly Produce IL-17 upon Receptor Ligation in an IL-6-Independent Fashion

(2014) A. V. Rachitskaya et al.   JOURNAL OF IMMUNOLOGY

The Intracellular Sensor NOD2 Induces MicroRNA-29 Expression in Human Dendritic Cells to Limit IL-23 Release

(2013) Oliver Brain et al.   IMMUNITY

Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora

(2013) Ju Qiu et al.   IMMUNITY

The Functions of Type I and Type II Natural Killer T Cells in Inflammatory Bowel Diseases

(2013) Chia-Min Liao et al.   INFLAMMATORY BOWEL DISEASES

Identification of Canonical Tyrosine-dependent and Non-canonical Tyrosine-independent STAT3 Activation Sites in the Intracellular Domain of the Interleukin 23 Receptor

(2013) Doreen M. Floss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation

(2013) Lisa A. Mielke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic

(2013) L. A. Zenewicz et al.   JOURNAL OF IMMUNOLOGY

IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism

(2013) A Eken et al.   Mucosal Immunology

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

(2013) Christoph S. N. Klose et al.   NATURE

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

(2013) Jochem H Bernink et al.   NATURE IMMUNOLOGY

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

(2013) Ansuman T Satpathy et al.   NATURE IMMUNOLOGY

IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis

(2013) C. L. Zindl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulated balance of retinoid-related orphan receptor γt-dependent innate lymphoid cells is involved in the pathogenesis of chronic DSS-induced colitis

(2012) Kayoko Kimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

T-helper 17 and Interleukin-17–Producing Lymphoid Tissue Inducer-Like Cells Make Different Contributions to Colitis in Mice

(2012) Yuichi Ono et al.   GASTROENTEROLOGY

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

(2012) Wolfgang Hueber et al.   GUT

The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells

(2012) Nick Powell et al.   IMMUNITY

Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense

(2012) Melissa A. Kinnebrew et al.   IMMUNITY

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+Th17 cells

(2012) Margherita Coccia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: A Variant of the IL-23R Gene Associated with Inflammatory Bowel Disease Induces Loss of MicroRNA Regulation and Enhanced Protein Production

(2012) A. Zwiers et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Suppress Development of Colitis, Blocking Differentiation of T-Helper 17 Into Alternative T-Helper 1 Cells

(2011) Tomohisa Sujino et al.   GASTROENTEROLOGY

Role of Interleukin-23 (IL-23) Receptor Signaling for IL-17 Responses in Human Lyme Disease

(2011) Marije Oosting et al.   INFECTION AND IMMUNITY

Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology

(2011) Masahito Kamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease

(2011) Alessandra Geremia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Generation of Colitogenic Th17 CD4 T Cells Is Enhanced by IL-17+    T Cells

(2011) J.-s. Do et al.   JOURNAL OF IMMUNOLOGY

The increased expression of IL-23 in inflammatory bowel disease promotes intraepithelial and lamina propria lymphocyte inflammatory responses and cytotoxicity

(2011) Z. Liu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice

(2011) J H Cox et al.   Mucosal Immunology

RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota

(2011) Shinichiro Sawa et al.   NATURE IMMUNOLOGY

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

(2011) Gregory F Sonnenberg et al.   NATURE IMMUNOLOGY

The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans

(2011) Paola Di Meglio et al.   PLoS One

Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q

(2011) Svetlana Pidasheva et al.   PLoS One

Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses

(2011) R. Sarin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increase of circulating γ/δ T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease

(2010) R. GIACOMELLI et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

(2010) Philip P. Ahern et al.   IMMUNITY

T Regulatory Cells Maintain Intestinal Homeostasis by Suppressing γδ T Cells

(2010) Sung-Gyoo Park et al.   IMMUNITY

Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate Lymphocytes

(2010) Cedric Vonarbourg et al.   IMMUNITY

E-Cadherin Marks a Subset of Inflammatory Dendritic Cells that Promote T Cell-Mediated Colitis

(2010) Karima R.R. Siddiqui et al.   IMMUNITY

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

(2010) Lydia Durant et al.   IMMUNITY

Cutting Edge: Crucial Role of IL-1 and IL-23 in the Innate IL-17 Response of Peripheral Lymph Node NK1.1- Invariant NKT Cells to Bacteria

(2010) J.-M. Doisne et al.   JOURNAL OF IMMUNOLOGY

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease

(2010) Yukihide Momozawa et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Lineage Relationship Analysis of RORγt+Innate Lymphoid Cells

(2010) Shinichiro Sawa et al.   SCIENCE

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Differential regulation of interleukin 17 and interferon   production in inflammatory bowel disease

(2009) L. Rovedatti et al.   GUT

Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions

(2009) Chen Varol et al.   IMMUNITY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Interleukin (IL)-23 mediatesToxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

(2009) Melba Muñoz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Skin and Peripheral Lymph Node Invariant NKT Cells Are Mainly Retinoic Acid Receptor-Related Orphan Receptor  t+ and Respond Preferentially under Inflammatory Conditions

(2009) J.-M. Doisne et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells

(2009) Amit Awasthi et al.   JOURNAL OF IMMUNOLOGY

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

IL-22 and inflammation: Leukin' through a glass onion

(2008) Lauren A. Zenewicz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Induction, function and regulation of IL-17-producing T cells

(2008) Kingston H. G. Mills   EUROPEAN JOURNAL OF IMMUNOLOGY

DC activated via dectin-1 convert Treg into IL-17 producers

(2008) Fabiola Osorio et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease

(2008) William J. Sandborn et al.   GASTROENTEROLOGY

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

(2008) Moritz Leppkes et al.   GASTROENTEROLOGY

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

(2008) T Kobayashi et al.   GUT

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis

(2008) Ana Izcue et al.   IMMUNITY

IL-23/IL-17 immunity as a hallmark of Crohnʼs disease

(2008) Veera Hölttä et al.   INFLAMMATORY BOWEL DISEASES

MAGI2 genetic variation and inflammatory bowel disease

(2008) Dermot P.B. McGovern et al.   INFLAMMATORY BOWEL DISEASES

Regulation of inflammatory responses by IL-17F

(2008) Xuexian O. Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells

(2008) Franca Gerosa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

(2008) Stephanie L Sanos et al.   NATURE IMMUNOLOGY

Exacerbating Role of γδ T Cells in Chronic Colitis of T-Cell Receptor α Mutant Mice

(2007) Masanobu Nanno et al.   GASTROENTEROLOGY