Critical Roles of Clostridium difficile Toxin B Enzymatic Activities in Pathogenesis

Pyknotic cell death induced byClostridium difficile TcdB: chromatin condensation and nuclear blister are induced independently of the glucosyltransferase activity

(2014) Katharina Wohlan et al.   CELLULAR MICROBIOLOGY

A Novel Multivalent, Single-Domain Antibody Targeting TcdA and TcdB Prevents Fulminant Clostridium difficile Infection in Mice

(2014) Zhiyong Yang et al.   JOURNAL OF INFECTIOUS DISEASES

Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore

(2014) Z. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins

(2014) B. Schorch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Single VHH-Based Toxin-Neutralizing Agent and an Effector Antibody Protect Mice against Challenge with Shiga Toxins 1 and 2

(2013) Jacqueline M. Tremblay et al.   INFECTION AND IMMUNITY

A novel approach to generate a recombinant toxoid vaccine against Clostridium difficile

(2013) R. G. K. Donald et al.   MICROBIOLOGY-SGM

A Segment of 97 Amino Acids within the Translocation Domain of Clostridium difficile Toxin B Is Essential for Toxicity

(2013) Yongrong Zhang et al.   PLoS One

Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex

(2013) M. A. Farrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clostridium difficile 027/BI/NAP1 Encodes a Hypertoxic and Antigenically Variable Form of TcdB

(2013) Jordi M. Lanis et al.   PLoS Pathogens

A Chimeric Toxin Vaccine Protects against Primary and Recurrent Clostridium difficile Infection

(2012) Haiying Wang et al.   INFECTION AND IMMUNITY

TcdB from hypervirulent Clostridium difficile exhibits increased efficiency of autoprocessing

(2012) Jordi M. Lanis et al.   MOLECULAR MICROBIOLOGY

Clostridium difficile Toxin B Causes Epithelial Cell Necrosis through an Autoprocessing-Independent Mechanism

(2012) Nicole M. Chumbler et al.   PLoS Pathogens

Cytotoxicity ofClostridium difficiletoxin B does not require cysteine protease-mediated autocleavage and release of the glucosyltransferase domain into the host cell cytosol

(2012) Shan Li et al.   Pathogens and Disease

Neutralization ofClostridium difficileToxin A with Single-domain Antibodies Targeting the Cell Receptor Binding Domain

(2011) Greg Hussack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic Dissemination of Clostridium difficile Toxins A and B Is Associated With Severe, Fatal Disease in Animal Models

(2011) Jennifer Steele et al.   JOURNAL OF INFECTIOUS DISEASES

Host S-nitrosylation inhibits clostridial small molecule–activated glucosylating toxins

(2011) Tor C Savidge et al.   NATURE MEDICINE

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins

(2011) Aimee Shen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium

(2010) Vanina Alzogaray et al.   FASEB JOURNAL

Clostridium difficileToxin A Decreases Acetylation of Tubulin, Leading to Microtubule Depolymerization through Activation of Histone Deacetylase 6, and This Mediates Acute Inflammation

(2010) Hyo Jung Nam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Four Distinct Structural Domains in Clostridium difficile Toxin B Visualized Using SAXS

(2010) David Albesa-Jové et al.   JOURNAL OF MOLECULAR BIOLOGY

The role of toxin A and toxin B in Clostridium difficile infection

(2010) Sarah A. Kuehne et al.   NATURE

Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A

(2010) Isa Kreimeyer et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Clostridial Glucosylating Toxins Enter Cells via Clathrin-Mediated Endocytosis

(2010) Panagiotis Papatheodorou et al.   PLoS One

Structural organization of the functional domains of Clostridium difficile toxins A and B

(2010) R. N. Pruitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific immuno capturing of the Staphylococcal superantigen toxic-shock syndrome toxin-1 in plasma

(2009) Hendrik Adams et al.   BIOTECHNOLOGY AND BIOENGINEERING

Clostridium difficile toxin A binds colonocyte Src causing dephosphorylation of focal adhesion kinase and paxillin

(2009) Ho Kim et al.   EXPERIMENTAL CELL RESEARCH

An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins

(2009) Xiangyun He et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Toxin B is essential for virulence of Clostridium difficile

(2009) Dena Lyras et al.   NATURE

Clostridium difficile infection: new developments in epidemiology and pathogenesis

(2009) Maja Rupnik et al.   NATURE REVIEWS MICROBIOLOGY

Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium

(2008) Guilin Yang et al.   BMC MICROBIOLOGY

Autocatalytic Processing ofClostridium difficileToxin B

(2008) Martina Egerer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processing of Clostridium difficile toxins

(2008) T. Giesemann et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Clostridium difficile— More Difficult Than Ever

(2008) Ciarán P. Kelly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure and mode of action of clostridial glucosylating toxins: the ABCD model

(2008) Thomas Jank et al.   TRENDS IN MICROBIOLOGY

Single-domain antibody fragments with high conformational stability

(2002) Mireille Dumoulin et al.   PROTEIN SCIENCE