Clostridium difficile Toxin B Causes Epithelial Cell Necrosis through an Autoprocessing-Independent Mechanism

TcdB from hypervirulent Clostridium difficile exhibits increased efficiency of autoprocessing

(2012) Jordi M. Lanis et al.   MOLECULAR MICROBIOLOGY

Host S-nitrosylation inhibits clostridial small molecule–activated glucosylating toxins

(2011) Tor C Savidge et al.   NATURE MEDICINE

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins

(2011) Aimee Shen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Difference in the biological effects of Clostridium difficile toxin B in proliferating and non-proliferating cells

(2011) Marta Lica et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Rational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdB

(2010) Aaron W. Puri et al.   CHEMISTRY & BIOLOGY

Assessment of Clostridium difficile Infections by Quantitative Detection of tcdB Toxin by Use of a Real-Time Cell Analysis System

(2010) A. B. Ryder et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The role of toxin A and toxin B in Clostridium difficile infection

(2010) Sarah A. Kuehne et al.   NATURE

Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A

(2010) Isa Kreimeyer et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Clostridial Glucosylating Toxins Enter Cells via Clathrin-Mediated Endocytosis

(2010) Panagiotis Papatheodorou et al.   PLoS One

Structural organization of the functional domains of Clostridium difficile toxins A and B

(2010) R. N. Pruitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a conserved membrane localization domain within numerous large bacterial protein toxins

(2010) B. Geissler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiapoptotic Proteins Bcl-2 and Bcl-XL Inhibit Clostridium difficile Toxin A-Induced Cell Death in Human Epithelial Cells

(2009) I. Matte et al.   INFECTION AND IMMUNITY

Structure-Function Analysis of Inositol Hexakisphosphate-induced Autoprocessing inClostridium difficileToxin A

(2009) Rory N. Pruitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxin B is essential for virulence of Clostridium difficile

(2009) Dena Lyras et al.   NATURE

Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells

(2008) R. Gerhard et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Clostridium difficile— More Difficult Than Ever

(2008) Ciarán P. Kelly et al.   NEW ENGLAND JOURNAL OF MEDICINE