Neutralization ofClostridium difficileToxin A with Single-domain Antibodies Targeting the Cell Receptor Binding Domain

A bispecific nanobody to provide full protection against lethal scorpion envenoming

(2010) Issam Hmila et al.   FASEB JOURNAL

mAb therapeutic products and risk management

(2010) Janice M. Reichert   mAbs

The role of toxin A and toxin B in Clostridium difficile infection

(2010) Sarah A. Kuehne et al.   NATURE

Treatment with Monoclonal Antibodies againstClostridium difficileToxins

(2010) Israel Lowy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural organization of the functional domains of Clostridium difficile toxins A and B

(2010) R. N. Pruitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toxin-Specific Antibodies for the Treatment of Clostridium difficile: Current Status and Future Perspectives

(2010) Greg Hussack et al.   Toxins

Enhancement of toxin- and virus-neutralizing capacity of single-domain antibody fragments by N-glycosylation

(2009) M. M. Harmsen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Treatment of Clostridium difficile-Associated Disease

(2009) Daniel A. Leffler et al.   GASTROENTEROLOGY

Clostridium difficile Infection Caused by the Epidemic BI/NAP1/027 Strain

(2009) Jennifer R. O'Connor et al.   GASTROENTEROLOGY

Inhibitory effect of REP3123 on toxin and spore formation in Clostridium difficile, and in vivo efficacy in a hamster gastrointestinal infection model

(2009) U. A. Ochsner et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Recurrent Clostridium difficile infection: A review of risk factors, treatments, and outcomes

(2009) Stuart Johnson   JOURNAL OF INFECTION

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

(2009) Janusz Wesolowski et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Toxin B is essential for virulence of Clostridium difficile

(2009) Dena Lyras et al.   NATURE

Clostridium difficile infection: new developments in epidemiology and pathogenesis

(2009) Maja Rupnik et al.   NATURE REVIEWS MICROBIOLOGY

Multivalent Anchoring and Oriented Display of Single-Domain Antibodies on Cellulose

(2009) Greg Hussack et al.   SENSORS

High-level expression of Camelid nanobodies in Nicotiana benthamiana

(2009) Yi-Hui Audrey Teh et al.   TRANSGENIC RESEARCH

A DNA vaccine targeting the receptor-binding domain of Clostridium difficile toxin A

(2009) David F. Gardiner et al.   VACCINE

Passive immunization with llama single-domain antibody fragments reduces foot-and-mouth disease transmission between pigs

(2009) M.M. Harmsen et al.   VACCINE

Development of Antiricin Single Domain Antibodies Toward Detection and Therapeutic Reagents

(2008) George P. Anderson et al.   ANALYTICAL CHEMISTRY

Thermostable Llama Single Domain Antibodies for Detection of Botulinum A Neurotoxin Complex

(2008) Ellen R. Goldman et al.   ANALYTICAL CHEMISTRY

Functional properties of the carboxy-terminal host cell-binding domains of the two toxins, TcdA and TcdB, expressed by Clostridium difficile

(2008) T. Dingle et al.   GLYCOBIOLOGY

Physical Characterization of Clostridium Difficile Toxins and Toxoids: Effect of the Formaldehyde Crosslinking on Thermal Stability

(2008) Maya S. Salnikova et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Llama Antibody Fragments with Cross-Subtype Human Immunodeficiency Virus Type 1 (HIV-1)-Neutralizing Properties and High Affinity for HIV-1 gp120

(2008) A. Forsman et al.   JOURNAL OF VIROLOGY

Llama-Derived Single-Chain Antibody Fragments Directed to Rotavirus VP6 Protein Possess Broad Neutralizing Activity In Vitro and Confer Protection against Diarrhea in Mice

(2008) L. Garaicoechea et al.   JOURNAL OF VIROLOGY

VHH, bivalent domains and chimeric Heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI′

(2008) Issam Hmila et al.   MOLECULAR IMMUNOLOGY

Cloning, expression, and characterization of a single-domain antibody fragment with affinity for 15-acetyl-deoxynivalenol

(2008) Patrick J. Doyle et al.   MOLECULAR IMMUNOLOGY

Aggregation-resistant VHs selected by in vitro evolution tend to have disulfide-bonded loops and acidic isoelectric points

(2008) M. Arbabi-Ghahroudi et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Structure and mode of action of clostridial glucosylating toxins: the ABCD model

(2008) Thomas Jank et al.   TRENDS IN MICROBIOLOGY

Single-domain antibody fragments with high conformational stability

(2002) Mireille Dumoulin et al.   PROTEIN SCIENCE