Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins

Rational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdB

(2010) Aaron W. Puri et al.   CHEMISTRY & BIOLOGY

The Acetyltransferase Activity of the Bacterial Toxin YopJ ofYersiniaIs Activated by Eukaryotic Host Cell Inositol Hexakisphosphate

(2010) Rohit Mittal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric regulation of protease activity by small molecules

(2010) Aimee Shen   Molecular BioSystems

The role of toxin A and toxin B in Clostridium difficile infection

(2010) Sarah A. Kuehne et al.   NATURE

NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation

(2010) B. C. Lechtenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural organization of the functional domains of Clostridium difficile toxins A and B

(2010) R. N. Pruitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inositol Hexakisphosphate-Induced Autoprocessing of Large Bacterial Protein Toxins

(2010) Martina Egerer et al.   PLoS Pathogens

Structural and Molecular Mechanism for Autoprocessing of MARTX Toxin ofVibrio choleraeat Multiple Sites

(2009) Katerina Prochazkova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Analysis of Inositol Hexakisphosphate-induced Autoprocessing inClostridium difficileToxin A

(2009) Rory N. Pruitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms

(2009) Chung-Jung Tsai et al.   Molecular BioSystems

Toxin B is essential for virulence of Clostridium difficile

(2009) Dena Lyras et al.   NATURE

Hidden alternative structures of proline isomerase essential for catalysis

(2009) James S. Fraser et al.   NATURE

Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin

(2009) Aimee Shen et al.   Nature Chemical Biology

Inhibition of a viral enzyme by a small-molecule dimer disruptor

(2009) Tina Shahian et al.   Nature Chemical Biology

Clostridium difficile infection: new developments in epidemiology and pathogenesis

(2009) Maja Rupnik et al.   NATURE REVIEWS MICROBIOLOGY

Trapping Moving Targets with Small Molecules

(2009) G. M. Lee et al.   SCIENCE

The Origin of Allosteric Functional Modulation: Multiple Pre-existing Pathways

(2009) Antonio del Sol et al.   STRUCTURE

Clostridium difficile toxins: More than mere inhibitors of Rho proteins

(2008) Harald Genth et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autocatalytic Processing ofClostridium difficileToxin B

(2008) Martina Egerer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Analysis of Inositol Hexakisphosphate-induced Autoprocessing of theVibrio choleraeMultifunctional Autoprocessing RTX Toxin

(2008) Katerina Prochazkova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Allosteric Circuit in Caspase-1

(2008) Debajyoti Datta et al.   JOURNAL OF MOLECULAR BIOLOGY

Allosteric regulation and catalysis emerge via a common route

(2008) Nina M Goodey et al.   Nature Chemical Biology

Inositol derivatives: evolution and functions

(2008) Robert H. Michell   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Clostridium difficile— More Difficult Than Ever

(2008) Ciarán P. Kelly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain

(2008) P. J. Lupardus et al.   SCIENCE

Structure and mode of action of clostridial glucosylating toxins: the ABCD model

(2008) Thomas Jank et al.   TRENDS IN MICROBIOLOGY