Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Binfeng Chen, Baokui Ye, Mengyuan Li, Shuyi Wang, Jin Li, Yimei Lai, Niansheng Yang, Zunfu Ke, Hui Zhang
Summary: This study identifies the critical role of TIGIT in regulating CD4(+) T-RM cells and demonstrates that TIGIT deficiency can ameliorate gut inflammation and tissue injury caused by colitis. This finding suggests the potential therapeutic value of targeting TIGIT in the treatment of IBDs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Mahesh Pandit, Suman Acharya, Ye Gu, Sang-Uk Seo, Mi-Na Kweon, Ben Kang, Jae-Hoon Chang
Summary: This study found that geranylgeranyl pyrophosphate (GGPP) can ameliorate DSS-induced colitis by increasing T-reg cells and enhancing IL-2/STAT 5 signaling. Additionally, GGPP increases IL-2 production through prenylation and activation of the Ras/ERK pathway.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Dewi Masyithah Darlan, Delfitri Munir, Agung Putra, Nelva Karmila Jusuf
Summary: This study found that MSCs promote the generation of iTreg cells from human SLE PBMCs by releasing TGF beta 1, which helps control the SLE disease.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Immunology
Aditi Sood, Marie-Eve Lebel, Mengqi Dong, Marilaine Fournier, Suzanne J. Vobecky, Elie Haddad, Jean-Sebastien Delisle, Judith N. Mandl, Nienke Vrisekoop, Heather J. Melichar
Summary: Studies show that CD5 levels correlate with TCR signal strength in human naive CD4(+) T cells, marking functional heterogeneity and dominance of CD5(hi) T cells in the memory compartment. Differences in gene expression and cytokine production between CD5(lo) and CD5(hi) naive human CD4(+) T cells are in line with observations in mice, suggesting potential for improving adoptive cell therapies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Min-zheng Zhu, Hao-ming Xu, Yu-jie Liang, Jing Xu, Ning-ning Yue, Yuan Zhang, Cheng-mei Tian, Jun Yao, Li-sheng Wang, Yu-qiang Nie, De-feng Li
Summary: This study found that nanoparticles derived from the edible plant Portulaca oleracea L can effectively treat ulcerative colitis. These nanoparticles have desirable nano-size and negative charge, which can suppress inflammation and increase anti-inflammatory factors to alleviate colitis symptoms. They are stable and safe in the gastrointestinal tract and have specific targeting to inflamed sites in the colon. These findings suggest that orally administered plant-derived nanoparticles have the potential to be a novel and natural colon-targeted therapy for managing ulcerative colitis.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Virology
Wanxiaojie Xie, Byungchul Lee, Kimberley Bruce, Clara Lawler, Helen E. Farrell, Philip G. Stevenson
Summary: Cytomegalovirus infections commonly cause problems in immunocompromised patients and in pregnancy. We lack effective vaccines. CD4(+) T cells play an important role in normal infection control, yet how they act has been unknown. Using murine cytomegalovirus as an accessible model, we show that CD4(+) T cells are unlikely to recognize infected cells directly. We propose that CD4(+) T cells interact with uninfected cells that present viral antigens and recruit other immune cells to attack infected targets. These data present a new outlook on understanding how CD4(+) T cell-directed control protects against persistent cytomegalovirus infection.
JOURNAL OF VIROLOGY
(2022)
Article
Pharmacology & Pharmacy
Inmaculada Serrano, Ana Luque, Alexandra Ruiz-Cerulla, Sergio Navas, Anna M. Blom, Santiago Rodriguez de Cordoba, Francisco J. Fernandez, M. Cristina Vega, Francisco Rodriguez-Moranta, Jordi Guardiola, Josep M. Aran
Summary: C4BP(beta-) and PRP6-HO7 showed strong anti-inflammatory and immunomodulatory effects, attenuating histopathological features and preserving intestinal epithelial integrity in murine colitis. These molecules downregulated inflammatory transcripts and reduced circulating inflammatory cytokines and chemokines. They also decreased inflammatory markers in myeloid cells from ulcerative colitis and Crohn's disease patients.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Immunology
Cecile Apert, Ariel O. Galindo-Albarran, Sarah Castan, Claire Detraves, Heloise Michaud, Nicola McJannett, Bart Haegeman, Simon Fillatreau, Bernard Malissen, Georg Hollander, Saulius Zuklys, Jeremy C. Santamaria, Olivier P. Joffre, Paola Romagnoli, Joost P. M. van Meerwijk
Summary: This study reevaluated the role of IL-2 and IL-15 in the development of regulatory T-lymphocytes (Treg) and found that IL-2 and IL-15 play important non-redundant quantitative and qualitative roles in intrathymic Treg development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Lianghui Diao, Alexandra Maximiliane Hierweger, Agnes Wieczorek, Petra Clara Arck, Kristin Thiele
Summary: The specific cross talk between pregnancy hormone progesterone and dendritic cells plays a crucial role in regulating the generation of regulatory T cells which are important for fetal development. Knockout of glucocorticoid receptor on dendritic cells improves placental function and fetal development, indicating a disrupted communication between glucocorticoids and dendritic cells favors a tolerant immune microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Agnese Fiori, Stefanie Uhlig, Harald Kluter, Karen Bieback
Summary: Mesenchymal stromal cells (MSC) have immunomodulatory effects on various immune cells. In this study, human adipose tissue-derived MSC (ASC) were found to inhibit CD4 + T cell proliferation, induce Treg cells, and modulate cytokine secretion, suggesting a potential role in immune regulation. These findings highlight the complex interplay between ASC and CD4 + T cells.
Article
Immunology
Sanmoy Pathak, Abhijeet Gokhroo, Ashim Kumar Dubey, Shamik Majumdar, Souradeep Gupta, Asha Almeida, Girish B. Mahajan, Abhijeet Kate, Prabhu Mishra, Rajiv Sharma, Sanjay Kumar, Ram Vishwakarma, Arun Balakrishnan, Hanudatta Atreya, Dipankar Nandi
Summary: Sesquiterpene lactone 7-hydroxy frullanolide (7HF) inhibits CD4+ T cell and peritoneal macrophage responses through regulating cell cycling and intracellular calcium levels, exhibiting anti-inflammatory potential in reducing immune responses.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Tengfei Xiao, Ping Zhang, Tongbao Feng, Kefeng Lu, Xiaoyan Wang, Siyuan Zhou, Yetao Qiang
Summary: Ulcerative colitis (UC) is a precancerous disease caused by a combination of genetic susceptibility, environmental factors, and microbiota dysbiosis. Butyrate has been shown to alleviate DSS-induced colitis by inhibiting proinflammatory mediators and synergistically regulating with MDSCs through CCR9 recruitment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daiki Yamada, Yudai Kojima, Akinori Hosoya, Masahiro Suzuki, Taro Watabe, Tadahiko Inoue, Naoya Tsugawa, Takehito Asakawa, Yuki Yonemoto, Michio Onizawa, Yasuhiro Nemoto, Shigeru Oshima, Motoyuki Shimonaka, Keiji Kuba, Junji Ishida, Akiyoshi Fukamizu, Josef M. Penninger, Mamoru Watanabe, Ryuichi Okamoto, Takashi Nagaishi
Summary: This study found that APL, an endogenous ligand for APJ, is upregulated in an acute colitis mouse model and in inflammatory bowel diseases (IBD) in humans. However, the mechanisms and functions of the APL/APJ axis in IBD are unclear. The researchers analyzed CD4+ T cells and found that APL expression was downregulated in the colonic tissue of a chronic colitis mouse model. Lack of APL resulted in decreased naive T cells and increased effecter T cells in secondary lymphoid organs. Administration of a synthetic APL peptide improved survival rate, lessened colitis severity, and decreased pro-inflammatory cytokine production.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Immunology
Kathrin Luise Braband, Annekathrin Silvia Nedwed, Sara Salome Helbich, Malte Simon, Niklas Beumer, Benedikt Brors, Federico Marini, Michael Delacher
Summary: ATAC-seq is a cutting-edge technology for assessing genome-wide chromatin accessibility. This article describes the complete workflow from isolating T cells from murine tissues to bioinformatic analysis, highlighting the methods and tools used.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Joseph E. Qualls, Peter J. Murray
SEMINARS IN IMMUNOPATHOLOGY
(2016)
Correction
Oncology
Ilaria Marigo, Serena Zilio, Giacomo Desantis, Bernhard Mlecnik, Andrielly H. R. Agnellini, Stefano Ugel, Maria Stella Sasso, Joseph E. Qualls, Franz Kratochvill, Paola Zanovello, Barbara Molon, Carola H. Ries, Valeria Runza, Sabine Noyes, Amelie M. Bilocq, Gabriela Bindea, Emilia M. C. Mazza, Silvio Bicciato, Jerome Galon, Peter J. Murray, Vincenzo Bronte
Article
Oncology
Ilaria Marigo, Serena Zilio, Giacomo Desantis, Bernhard Mlecnik, Andrielly H. R. Agnellini, Stefano Ugel, Maria Stella Sasso, Joseph E. Qualls, Franz Kratochvill, Paola Zanovello, Barbara Molon, Carola H. Ries, Valeria Runza, Sabine Hoves, Amelie M. Bilocq, Gabriela Bindea, Emilia M. C. Mazza, Silvio Bicciato, Jerome Galon, Peter J. Murray, Vincenzo Bronte
Article
Biochemistry & Molecular Biology
Lee-Ann Van de Velde, Chitra Subramanian, Amber M. Smith, Luke Barron, Joseph E. Qualls, Geoffrey Neale, Adolfo Alfonso-Pecchio, Suzanne Jackowski, Charles O. Rock, Thomas A. Wynn, Peter J. Murray
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Oncology
Nina Bertaux-Skeirik, Mark Wunderlich, Emma Teal, Jayati Chakrabarti, Jacek Biesiada, Maxime Mahe, Nambirajan Sundaram, Joel Gabre, Jennifer Hawkins, Gao Jian, Amy C. Engevik, Li Yang, Jiang Wang, James R. Goldenring, Joseph E. Qualls, Mario Medvedovic, Michael A. Helmrath, Tayyab Diwan, James C. Mulloy, Yana Zavros
JOURNAL OF PATHOLOGY
(2017)
Article
Immunology
Shannon M. Lange, Melanie C. McKell, Stephanie M. Schmidt, Austin P. Hossfeld, Vandana Chaturvedi, Jeremy M. Kinder, Jaclyn W. McAlees, Ian P. Lewkowich, Sing Sing Way, Joanne Turner, Joseph E. Qualls
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Immunology
Shannon M. Lange, Melanie C. McKell, Stephanie M. Schmidt, Junfang Zhao, Rebecca R. Crowther, Lisa C. Green, Rebecca L. Bricker, Eusondia Arnett, S. Eleonore Kohler, Larry S. Schlesinger, Kenneth D. R. Setchell, Joseph E. Qualls
JOURNAL OF IMMUNOLOGY
(2019)
Article
Hematology
Alexander A. Boucher, Leah Rosenfeldt, Duaa Mureb, Jessica Shafer, Bal Krishan Sharma, Adam Lane, Rebecca R. Crowther, Melanie C. McKell, Jordan Whitt, Theresa Alenghat, Joseph Qualls, Silvio Antoniak, Nigel Mackman, Matthew J. Flick, Kris A. Steinbrecher, Joseph S. Palumbo
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Review
Immunology
Jarren R. Oates, Melanie C. McKell, Maria E. Moreno-Fernandez, Michelle S. M. A. Damen, George S. Deepe, Joseph E. Qualls, Senad Divanovic
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
Moises A. Huaman, Joseph E. Qualls, Shinsmon Jose, Stephanie M. Schmidt, Anissa Moussa, David G. Kuhel, Eddy Konaniah, Ravi K. Komaravolu, Carl J. Fichtenbaum, George S. Deepe, David Y. Hui
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Immunology
Rebecca R. Crowther, Joseph E. Qualls
Summary: This article provides a summary of the current knowledge on anti-Mtb immunity, focusing on immune cell amino acid metabolism, specifically discussing the roles of L-arginine and L-tryptophan in TB patients. By uncovering the immune cell contribution during Mtb infection and how amino acid utilization regulates their functions, novel host-directed therapies may be developed and refined to help eradicate TB.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Melanie C. McKell, Rebecca R. Crowther, Stephanie M. Schmidt, Michelle C. Robillard, Rachel Cantrell, Maria A. Lehn, Edith M. Janssen, Joseph E. Qualls
Summary: Macrophages rely on L-arginine for anti-Mtb defense, not only for NO production but also for regulating metabolism and other host defense mechanisms. Inhibition of glycolysis or mTOR reduces macrophage control of Mtb, as well as macrophage number and viability in the presence of L-arginine. L-arginine is essential for macrophage function in combating intracellular pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Vivienne Woo, Emily M. Eshleman, Seika Hashimoto-Hill, Jordan Whitt, Shu-en Wu, Laura Engleman, Taylor Rice, Rebekah Karns, Joseph E. Qualls, David B. Haslam, Bruce A. Vallance, Theresa Alenghat
Summary: The study reveals that commensal bacteria SFB associated with intestinal epithelial cells can promote early protection against pathogens by enhancing the defense function of retinoic acid (RA). RA is identified as an unexpected microbiota-derived metabolite that primes innate defense, suggesting that increasing RA levels could prevent or combat infections.
CELL HOST & MICROBE
(2021)
Article
Immunology
Rebecca R. Crowther, Stephanie M. Schmidt, Shannon M. Lange, Melanie C. McKell, Michelle C. Robillard, Junfang Zhao, Wendy D. Haffey, Michael A. Wyder, Kenneth D. Greis, Kenneth D. R. Setchell, Joseph E. Qualls
Summary: Changes in amino acid abundance, particularly L-arginine (L-ARG), have been observed in patients with tuberculosis. This study shows that immune cells, specifically APCs, are capable of synthesizing L-ARG to support T cell viability and activation. The findings expand our understanding of APC-T cell interactions and the role of nutrient availability in immune cells.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Microbiology
Heather M. Evans, Destiny F. Schultz, Adam J. Boiman, Melanie C. McKell, Joseph E. Qualls, George S. Deepe
Summary: HIF-1 alpha regulates the immunometabolic phenotype of macrophages, with its absence leading to overproduction of IL-10, hindering cell activation and allowing pathogen proliferation. Accumulation of fumarate in the absence of HIF-1 alpha drives IL-10 production and alters miR-27a regulation of IL-10, impacting fungal growth.