T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions

T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells

(2016) Ilaria Marigo et al.   CANCER CELL

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

(2016) Roger Geiger et al.   CELL

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8 + T Cells

(2016) Sarah H. Ross et al.   IMMUNITY

Proliferating Helper T Cells Require Rictor/mTORC2 Complex to Integrate Signals from Limiting Environmental Amino Acids

(2016) Lee-Ann Van de Velde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

(2016) Robert A. Saxton et al.   NATURE

Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing

(2016) Lee-Ann Van de Velde et al.   Cell Reports

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

(2016) Bernadette Carroll et al.   eLife

Induced arginine transport via cationic amino acid transporter-1 is necessary for human T-cell proliferation

(2015) Anke Werner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Amino acid auxotrophy as a system of immunological control nodes

(2015) Peter J Murray   NATURE IMMUNOLOGY

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Regulation of T cells by mTOR: the known knowns and the known unknowns

(2015) Kristen N. Pollizzi et al.   TRENDS IN IMMUNOLOGY

Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct

(2014) U. M. Gundra et al.   BLOOD

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

Incomplete Deletion of IL-4Rα by LysMCre Reveals Distinct Subsets of M2 Macrophages Controlling Inflammation and Fibrosis in Chronic Schistosomiasis

(2014) Kevin M. Vannella et al.   PLoS Pathogens

Ly6Chi Monocyte Recruitment Is Responsible for Th2 Associated Host-Protective Macrophage Accumulation in Liver Inflammation due to Schistosomiasis

(2014) Marcia Nascimento et al.   PLoS Pathogens

T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming

(2013) Kai Yang et al.   IMMUNITY

Coupled IL-2-Dependent Extracellular Feedbacks Govern Two Distinct Consecutive Phases of CD4 T Cell Activation

(2013) N. Waysbort et al.   JOURNAL OF IMMUNOLOGY

Amino acid signalling upstream of mTOR

(2013) Jenna L. Jewell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation

(2013) Luke Barron et al.   PLoS One

Sustained Generation of Nitric Oxide and Control of Mycobacterial Infection Requires Argininosuccinate Synthase 1

(2012) Joseph E. Qualls et al.   Cell Host & Microbe

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

(2012) Aron M. Levin et al.   NATURE

Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase

(2012) Tracy L Keller et al.   Nature Chemical Biology

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Macrophage activation governs schistosomiasis-induced inflammation and fibrosis

(2011) Luke Barron et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

(2011) Kai Yang et al.   NATURE IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity

(2010) M. N. Offman et al.   BLOOD

Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2

(2010) S. Huber et al.   BLOOD

Modulation of human lymphocyte proliferation by amino acids

(2010) J. C. CHUANG et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Arginase I Suppresses IL-12/IL-23p40-Driven Intestinal Inflammation during Acute Schistosomiasis

(2010) D. R. Herbert et al.   JOURNAL OF IMMUNOLOGY

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Coordination of Lipid Metabolism in Membrane Biogenesis

(2009) Axel Nohturfft et al.   Annual Review of Cell and Developmental Biology

Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via L-Arginine Metabolism

(2009) L. A. Norian et al.   CANCER RESEARCH

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Restriction of Chlamydia pneumoniae replication in human dendritic cell by activation of indoleamine 2,3-dioxygenase

(2009) Florence Njau et al.   MICROBES AND INFECTION

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

(2009) S. P. Cobbold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

(2009) John T. Pesce et al.   PLoS Pathogens

LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response

(2008) Steven J. Bensinger et al.   CELL

Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

(2008) Karim C El Kasmi et al.   NATURE IMMUNOLOGY