Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1

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A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS

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Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

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Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease

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Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice

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Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex

(2012) Atsushi Sato et al.   Nature Communications

The acquisition of resistance to TNFα in breast cancer cells is associated with constitutive activation of autophagy as revealed by a transcriptome analysis using a custom microarray

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Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex

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Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

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TFEB Links Autophagy to Lysosomal Biogenesis

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ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

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Transforming growth factor-β enhances matrix metalloproteinase-2 expression and activity through AKT in fibroblasts derived from angiofibromas in patients with tuberous sclerosis complex

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TOR on the brain

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Tsc2-Rheb signaling regulates EphA-mediated axon guidance

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A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

(2010) A. S. Tsvetkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

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A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

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ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

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Tuberous Sclerosis Complex Activity Is Required to Control Neuronal Stress Responses in an mTOR-Dependent Manner

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An Atg1/Atg13 Complex with Multiple Roles in TOR-mediated Autophagy Regulation

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ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

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Tuberous sclerosis complex proteins control axon formation

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UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly

(2008) H. Toda et al.   GENES & DEVELOPMENT

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology