Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence

The Genetics of Substance Dependence

(2012) Jen-Chyong Wang et al.   Annual Review of Genomics and Human Genetics

The stereotypy-inducing and OCD-like effects of chronic ‘binge’ cocaine are modulated by distinct subtypes of nicotinic acetylcholine receptors

(2012) A Metaxas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of nicotinic acetylcholine receptor agonists on cognition in rhesus monkeys with a chronic cocaine self-administration history

(2012) Robert W. Gould et al.   NEUROPHARMACOLOGY

Varenicline decreases alcohol consumption in heavy-drinking smokers

(2012) Jennifer M. Mitchell et al.   PSYCHOPHARMACOLOGY

Role of nicotinic acetylcholine receptors in the effects of cocaine-paired contextual stimuli on impulsive decision making in rats

(2012) Xiaohu Xie et al.   PSYCHOPHARMACOLOGY

Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes

(2012) J. A. Tennessen et al.   SCIENCE

Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats

(2011) Jade J. Bito-Onon et al.   ADDICTION BIOLOGY

Rare Nonsynonymous Variants in Alpha-4 Nicotinic Acetylcholine Receptor Gene Protect Against Nicotine Dependence

(2011) Pingxing Xie et al.   BIOLOGICAL PSYCHIATRY

Nicotinic acetylcholine receptors containing the α4 subunit are critical for the nicotine-induced reduction of acute voluntary ethanol consumption

(2011) Linzy M. Hendrickson et al.   Channels

Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence

(2011) Gabe Haller et al.   HUMAN MOLECULAR GENETICS

 4 2 Nicotinic Acetylcholine Receptors on Dopaminergic Neurons Mediate Nicotine Reward and Anxiety Relief

(2011) T. M. McGranahan et al.   JOURNAL OF NEUROSCIENCE

Ethanol-induced modulation of synaptic output from the dorsolateral striatum in rat is regulated by cholinergic interneurons

(2011) Louise Adermark et al.   NEUROCHEMISTRY INTERNATIONAL

Genetic Vulnerability and Susceptibility to Substance Dependence

(2011) Laura Jean Bierut   NEURON

Varenicline attenuates cue-induced relapse to alcohol, but not nicotine seeking, while reducing inhibitory response control

(2011) Jelte A. Wouda et al.   PSYCHOPHARMACOLOGY

The Nicotinic Acetylcholine Receptor Partial Agonist Varenicline Increases the Ataxic and Sedative-Hypnotic Effects of Acute Ethanol Administration in C57BL/6J Mice

(2010) Helen M. Kamens et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Delineation of the Role of Nicotinic Acetylcholine Receptor Genes in Alcohol Preference in Mice

(2010) Melissa N. Symons et al.   BEHAVIOR GENETICS

Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) α4β2- and α7 subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia

(2010) Najla Taslim et al.   BEHAVIOURAL BRAIN RESEARCH

Chronic nicotine treatment differentially modifies acute nicotine and alcohol actions on GABAA and glutamate receptors in hippocampal brain slices

(2010) William R Proctor et al.   BRITISH JOURNAL OF PHARMACOLOGY

High-throughput discovery of rare insertions and deletions in large cohorts

(2010) F. L. M. Vallania et al.   GENOME RESEARCH

Activation of  4* nAChRs is Necessary and Sufficient for Varenicline-Induced Reduction of Alcohol Consumption

(2010) L. M. Hendrickson et al.   JOURNAL OF NEUROSCIENCE

Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease

(2010) Yukihide Momozawa et al.   NATURE GENETICS

Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior

(2010) Thorgeir E Thorgeirsson et al.   NATURE GENETICS

Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia

(2010) Christopher T Johansen et al.   NATURE GENETICS

Variation in Nicotinic Acetylcholine Receptor Genes is Associated with Multiple Substance Dependence Phenotypes

(2010) Richard Sherva et al.   NEUROPSYCHOPHARMACOLOGY

Resequencing of Nicotinic Acetylcholine Receptor Genes and Association of Common and Rare Variants with the Fagerström Test for Nicotine Dependence

(2010) Jennifer Wessel et al.   NEUROPSYCHOPHARMACOLOGY

Partial Agonists of the α3β4* Neuronal Nicotinic Acetylcholine Receptor Reduce Ethanol Consumption and Seeking in Rats

(2010) Susmita Chatterjee et al.   NEUROPSYCHOPHARMACOLOGY

Nicotinic acetylcholine receptors of the dorsal hippocampus and the basolateral amygdala are involved in ethanol-induced conditioned place preference

(2010) M.R. Zarrindast et al.   NEUROSCIENCE

Nicotinic Ligands Modulate Ethanol-Induced Dopamine Function in Mice

(2010) Ravi K. Sajja et al.   PHARMACOLOGY

Effects of sazetidine-A, a selective α4β2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats

(2010) Amir H. Rezvani et al.   PSYCHOPHARMACOLOGY

Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD

(2010) Nancy L. Saccone et al.   PLoS Genetics

Nicotinic receptor ligands reduce ethanol intake by high alcohol–drinking HAD-2 rats

(2009) Richard L. Bell et al.   ALCOHOL

Common vs. rare allele hypotheses for complex diseases

(2009) Nicholas J Schork et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample

(2009) N. R. Hoft et al.   GENES BRAIN AND BEHAVIOR

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5

(2009) Jen C. Wang et al.   HUMAN MOLECULAR GENETICS

Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility

(2009) Gabe Haller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Quantification of rare allelic variants from pooled genomic DNA

(2009) Todd E Druley et al.   NATURE METHODS

Lobeline, a nicotinic partial agonist attenuates alcohol consumption and preference in male C57BL/6J mice

(2009) Justin M. Farook et al.   PHYSIOLOGY & BEHAVIOR

Estimating Local Ancestry in Admixed Populations

(2008) Sriram Sankararaman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic and Environmental Influences on Alcohol, Caffeine, Cannabis, and Nicotine Use From Early Adolescence to Middle Adulthood

(2008) Kenneth S. Kendler et al.   ARCHIVES OF GENERAL PSYCHIATRY

A Risk Allele for Nicotine Dependence in CHRNA5 Is a Protective Allele for Cocaine Dependence

(2008) Richard A. Grucza et al.   BIOLOGICAL PSYCHIATRY

Drug use and dependence in cocaine dependent subjects, community-based individuals, and their siblings

(2008) Laura Jean Bierut et al.   DRUG AND ALCOHOL DEPENDENCE

The α3 subunit gene of the nicotinic acetylcholine receptor is a candidate gene for ethanol stimulation

(2008) H. M. Kamens et al.   GENES BRAIN AND BEHAVIOR

Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence

(2008) J C Wang et al.   MOLECULAR PSYCHIATRY

Effects of moderate chronic ethanol consumption on hippocampal nicotinic receptors and associative learning

(2008) Noemi Robles et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking behavior

(2008) Alexander Kuzmin et al.   PSYCHOPHARMACOLOGY