Article
Neurosciences
M. Adrienne McGinn, Brendan J. Tunstall, Joel E. Schlosburg, Adriana Gregory-Flores, Olivier George, Giordano de Guglielmo, Barbara J. Mason, Hazel J. Hunt, George F. Koob, Leandro F. Vendruscolo
Summary: The study demonstrated the potential of GR modulators in reducing alcohol consumption, with different effects observed in different circumstances. These findings provide insights for the development of treatments for AUD.
Review
Neurosciences
Janna K. Moen, Anna M. Lee
Summary: Alcohol and nicotine, the two most widely used and misused drugs globally, show significant sex differences in their rewarding properties, yet most preclinical studies on their mechanisms utilize only male rodents. Understanding the influence of sex and sex hormones on alcohol and nicotine reward is crucial for developing therapies to reduce drug consumption.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Nutrition & Dietetics
David Nutt, Alexandra Hayes, Leon Fonville, Rayyan Zafar, Emily O. C. Palmer, Louise Paterson, Anne Lingford-Hughes
Summary: Alcohol affects the brain in various harmful ways, including damage during intoxication, withdrawal effects, and peripheral factors like poor diet and vitamin deficiencies. Prenatal alcohol exposure can also have lasting impacts on brain development.
Review
Biochemistry & Molecular Biology
Segev Barak, Koral Goltseker
Summary: Studies indicate that intervening in the reconsolidation of alcohol and nicotine/tobacco memories may help reduce relapse, serving as a potential strategy to suppress relapse to alcohol drinking and tobacco smoking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Melissa A. Tapia, Xiao-Tao Jin, Brenton R. Tucker, Leanne N. Thomas, Noah B. Walker, Veronica J. Kim, Steven E. Albertson, Naresh Damuka, Ivan Krizan, Seby Edassery, Jeffrey N. Savas, Kiran Kumar Solingapuram Sai, Sara R. Jones, Ryan M. Drenan
Summary: This study investigated the behavior and neurobiological effects of intermittent nicotine intake in rats. The results suggest that intermittent nicotine intake may lead to increased craving and enhanced response to nicotine-associated cues. Additionally, intermittent nicotine intake also caused increased nicotine binding in the brain and specific changes in the proteome of certain neural structures.
Article
Neurosciences
Xiao-Tao Jin, Ryan M. Drenan
Summary: The interpeduncular nucleus (IPN) is involved in nicotine dependence and regulation of fear responses, affective states, and novelty processing. Neurons in the IPN express nicotinic acetylcholine receptors (nAChR) and receive cholinergic innervation. Studies have shown that IPL neurons express Chrna7 (alpha 7 nAChR subunit) and are sensitive to acetylcholine (ACh) stimulation. These findings contribute to a better understanding of cholinergic modulation in the IPN.
Article
Biochemistry & Molecular Biology
Rayane Tabbara, Zhaoxia Li, Paul J. Fletcher, Anh D. Le
Summary: Lorcaserin and naltrexone both reduce binge-like EtOH drinking, with a greater effect when used in combination, supporting further research into the therapeutic potential of lorcaserin for alcohol use disorders.
Article
Emergency Medicine
Ethan Forsgren, Athreya Steiger, Yesenia Perez, David Salazar, Maureen McCollough, Breena R. R. Taira
Summary: The study aimed to identify barriers and facilitators perceived by patients to initiate NTX treatment in the ED. The findings suggest that knowledgeable providers of NTX, effective management of withdrawal symptoms, and connecting patients to providers who will continue treatment can facilitate patients' acceptance of NTX treatment, thus improving the treatment pathway in the ED.
ACADEMIC EMERGENCY MEDICINE
(2023)
Article
Neurosciences
Simon N. Katner, Alena M. Sentir, Kevin B. Steagall, Zheng-Ming Ding, Leah Wetherill, Frederic W. Hopf, Eric A. Engleman
Summary: Understanding risk factors that increase the development of addiction is crucial, and studying genetically-selected EtOH-preferring rodents can provide insights into mechanisms underlying compulsive drinking and lead to new treatments for AUDs.
Article
Neurosciences
Saeideh Karimi-Haghighi, Yasaman Razavi, Daniela Iezzi, Andrew F. Scheyer, Olivier Manzoni, Abbas Haghparast
Summary: This review article summarizes the effects of cannabidiol (CBD) in various models of drug abuse, including opioids, psychostimulants, cannabis, alcohol, and nicotine. It also reviews the possible mechanisms underlying the therapeutic potential of CBD in treating addiction.
Article
Public, Environmental & Occupational Health
Brenda Caira-Chuquineyra, Daniel Fernandez-Guzman, Carlos Quispe-Vicuna, Raysa Gutierrez-Rodriguez, Pablo D. Valencia
Summary: The aim of this study was to evaluate the factors associated with alcohol abuse in the Peruvian population. The results showed that education level, marital status, socioeconomic level, region, health insurance, smoking, and depression were associated with a higher prevalence of alcohol abuse.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Psychology, Biological
Roberto U. Cofresi, Thomas M. Piasecki, Greg Hajcak, Bruce D. Bartholow
Summary: This study found that individual differences in P3 signals elicited by alcohol cues are highly reliable and stable over 8-10 months, while individual differences in alcohol cue-specific P3 reactivity are less reliable and stable. The conditions under which neural signals specific to alcohol/drug cues are adequately reliable and stable remain unknown.
Article
Multidisciplinary Sciences
Shoupeng Wei, Sarah Hertle, Rainer Spanagel, Ainhoa Bilbao
Summary: The study reveals that female mice are more vulnerable to the addictive properties of sugar than male mice, showing higher binge and long-term, excessive drinking, a more pronounced relapse-like drinking following deprivation, as well as higher persistence and motivation for sugar. No sex differences were seen in a compulsivity test or reward sensitivity following extended sugar consumption.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Natalia A. Quijano Carde, Jessica Shaw, Christina Carter, Seung Kim, Jerry A. Stitzel, Shyamala K. Venkatesh, Vijay A. Ramchandani, Mariella De Biasi
Summary: Alcohol and nicotine use during adolescence can lead to long-term neuroplastic changes that affect subsequent drug use. This study found that variation in the CHRNA5 gene is associated with drinking and smoking behaviors. Disruption of the alpha 5 nAChR subunit increases nicotine intake, particularly in adolescent female mice, while the effect on alcohol intake is more prominent in females. Additionally, adolescent alcohol or nicotine exposure can modulate subsequent intake of the opposite drug in adulthood, and this effect is influenced by sex and Chrna5 mutation.
Review
Psychology, Clinical
Mariangela Antonelli, Liana Fattore, Luisa Sestito, Daniela Di Giuda, Marco Diana, Giovanni Addolorato
Summary: Repetitive TMS has shown promising results in patients with alcohol, tobacco, and cocaine use disorder, indicating a potential role in the treatment of SUD.
ADDICTIVE BEHAVIORS
(2021)