Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes

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Transcription Deregulation at the 15q25 Locus in Association with Lung Adenocarcinoma Risk

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Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with ‘pleasurable buzz’ during early experimentation with smoking

(2008) Richard Sherva et al.   ADDICTION

Variants in Nicotinic Receptors and Risk for Nicotine Dependence

(2008) Laura Jean Bierut et al.   AMERICAN JOURNAL OF PSYCHIATRY

In search of causal variants: refining disease association signals using cross-population contrasts

(2008) Nancy L Saccone et al.   BMC GENETICS

Nicotinic Receptor Gene Variants Influence Susceptibility to Heavy Smoking

(2008) V. L. Stevens et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines

(2008) Piyali Dasgupta et al.   INTERNATIONAL JOURNAL OF CANCER

Developmental Excitation of Corticothalamic Neurons by Nicotinic Acetylcholine Receptors

(2008) S. M. Kassam et al.   JOURNAL OF NEUROSCIENCE

Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer

(2008) Pengyuan Liu et al.   JNCI-Journal of the National Cancer Institute

Roles of Accessory Subunits in  4 2* Nicotinic Receptors

(2008) A. Kuryatov et al.   MOLECULAR PHARMACOLOGY

Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence

(2008) J C Wang et al.   MOLECULAR PSYCHIATRY

α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking

(2008) W Berrettini et al.   MOLECULAR PSYCHIATRY

Multiple roles of nicotine on cell proliferation and inhibition of apoptosis: Implications on lung carcinogenesis

(2008) A CATASSI et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

(2008) Thorgeir E. Thorgeirsson et al.   NATURE

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

(2008) Rayjean J. Hung et al.   NATURE

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

(2008) Christopher I Amos et al.   NATURE GENETICS

A Candidate Gene Approach Identifies the CHRNA5-A3-B4 Region as a Risk Factor for Age-Dependent Nicotine Addiction

(2008) Robert B. Weiss et al.   PLoS Genetics