Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma

Suppression of Glypican 3 Inhibits Growth of Hepatocellular Carcinoma Cells through Up-Regulation of TGF-β2

(2015) Chris K. Sun et al.   NEOPLASIA

Crystal Structure ofN-Glycosylated Human Glypican-1 Core Protein

(2012) Gabriel Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-affinity monoclonal antibodies to cell surface tumor antigen glypican-3 generated through a combination of peptide immunization and flow cytometry screening

(2012) Yen Phung et al.   mAbs

NSC 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma

(2011) Wei Chen et al.   LIVER INTERNATIONAL

Anthracyclines disrupt telomere maintenance by telomerase through inducing PinX1 ubiquitination and degradation

(2011) B Zhang et al.   ONCOGENE

Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling

(2011) Min-Sung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of a humanized anti-glypican 3 antibody by CDR grafting and stability optimization

(2010) Kiyotaka Nakano et al.   ANTI-CANCER DRUGS

Proapoptotic Kinase MST2 Coordinates Signaling Crosstalk between RASSF1A, Raf-1, and Akt

(2010) D. Romano et al.   CANCER RESEARCH

Glypican-3: A new target for cancer immunotherapy

(2010) Mitchell Ho et al.   EUROPEAN JOURNAL OF CANCER

Suppression of liver regeneration and hepatocyte proliferation in hepatocyte-targeted glypican 3 transgenic mice

(2010) Bowen Liu et al.   HEPATOLOGY

Recombinant soluble glypican 3 protein inhibits the growth of hepatocellular carcinoma in vitro

(2010) Mingqian Feng et al.   INTERNATIONAL JOURNAL OF CANCER

Mammalian Ste20-like Kinase (Mst2) Indirectly Supports Raf-1/ERK Pathway Activity via Maintenance of Protein Phosphatase-2A Catalytic Subunit Levels and Consequent Suppression of Inhibitory Raf-1 Phosphorylation

(2010) Geoffrey K. Kilili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Proapoptotic Mammalian ste20–Like Kinase MST2 by the IGF1-Akt Pathway

(2010) Donghwa Kim et al.   PLoS One

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

(2010) K.-P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

Glypican 3 Expression in Human Nonneoplastic, Preneoplastic, and Neoplastic Tissues

(2008) Daniel Baumhoer et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells

(2008) Kiyotaka Nakano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-Glypican 3 Antibody as a Potential Antitumor Agent for Human Liver Cancer

(2008) T. Ishiguro et al.   CANCER RESEARCH

A Binding Domain on Mesothelin for CA125/MUC16

(2008) Osamu Kaneko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Glycosylation as Novel Strategy to Improve Pharmacokinetic Properties of Bispecific Single-chain Diabodies

(2008) Roland Stork et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Construction of a Large Phage-Displayed Human Antibody Domain Library with a Scaffold Based On a Newly Identified Highly Soluble, Stable Heavy Chain Variable Domain

(2008) Weizao Chen et al.   JOURNAL OF MOLECULAR BIOLOGY