How to cope with the quest for new antibiotics

Challenges of antibacterial discovery revisited

(2010) Michael N. Gwynn et al.   Annals of the New York Academy of Sciences

Antimicrobial Activity of CHIR-090, an Inhibitor of Lipopolysaccharide Biosynthesis, against the Burkholderia cepacia Complex

(2010) K. Bodewits et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sources of novel antibiotics—aside the common roads

(2010) Stefano Donadio et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The transcription inhibitor lipiarmycin blocks DNA fitting into the RNA polymerase catalytic site

(2010) Audrey Tupin et al.   EMBO JOURNAL

Postgenomic strategies in antibacterial drug discovery

(2010) Heike Brötz-Oesterhelt et al.   Future Microbiology

Novel Small Molecule Inhibitors of MDRMycobacterium tuberculosisby NMR Fragment Screening of Antigen 85C

(2010) Christoph Scheich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Type IIA topoisomerase inhibition by a new class of antibacterial agents

(2010) Benjamin D. Bax et al.   NATURE

Antibiotic resistance and its cost: is it possible to reverse resistance?

(2010) Dan I. Andersson et al.   NATURE REVIEWS MICROBIOLOGY

Peptidomimetic Antibiotics Target Outer-Membrane Biogenesis in Pseudomonas aeruginosa

(2010) N. Srinivas et al.   SCIENCE

Novel Riboswitch Ligand Analogs as Selective Inhibitors of Guanine-Related Metabolic Pathways

(2010) Jérôme Mulhbacher et al.   PLoS Pathogens

Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches

(2009) Igor Mochalkin et al.   ACS Chemical Biology

In Vitro Bactericidal Activity of Iclaprim in Human Plasma

(2009) H. Laue et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA

(2009) Katherine A. Rawls et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Simocyclinone D8 turns on against Gram-negative bacteria in a clinical setting

(2009) Sara N. Richter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of Distinct Thiopeptide-Antibiotic Precursor Lead Compounds Using Translation Machinery Assays

(2009) Agata L. Starosta et al.   CHEMISTRY & BIOLOGY

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

(2009) Janine Kirstein et al.   EMBO Molecular Medicine

Future antibiotics scenarios: is the tide starting to turn?

(2009) Ursula Theuretzbacher   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity

(2009) N. Ooi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A class of selective antibacterials derived from a protein kinase inhibitor pharmacophore

(2009) J. Richard Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

(2008) A. A. Miller et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Isolation, structure, and antibacterial activity of thiazomycin A, a potent thiazolyl peptide antibiotic from Amycolatopsis fastidiosa

(2008) Chaowei Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase

(2008) Justin I. Montgomery et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The RNA Polymerase “Switch Region” Is a Target for Inhibitors

(2008) Jayanta Mukhopadhyay et al.   CELL

Initiation of protein synthesis: a target for antimicrobials

(2008) Letizia Brandi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Isolation, Structure, and Antibacterial Activity of Philipimycin, A Thiazolyl Peptide Discovered fromActinoplanes philippinensisMA7347

(2008) Chaowei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

(2008) D. N. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting QseC Signaling and Virulence for Antibiotic Development

(2008) D. A. Rasko et al.   SCIENCE

An Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity

(2008) D. J. Haydon et al.   SCIENCE