Article
Agriculture, Dairy & Animal Science
Jing Wang, Wentao Lyu, Wei Zhang, Yonghong Chen, Fang Luo, Yamin Wang, Haifeng Ji, Guolong Zhang
Summary: The study demonstrates that the newly-identified natural HDP-inducing compounds, identified through high-throughput screening, can stimulate endogenous HDP synthesis, enhance antibacterial activity against various bacteria in pigs, and have the potential to serve as alternatives to antibiotics in livestock production for prophylactic and therapeutic treatment of infectious diseases.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Gina Porras, Francois Chassagne, James T. Lyles, Lewis Marquez, Micah Dettweiler, Akram M. Salam, Tharanga Samarakoon, Sarah Shabih, Darya Raschid Farrokhi, Cassandra L. Quave
Summary: The crisis of antibiotic resistance highlights the importance of exploring plant natural products as a potential source of antibacterial compounds. This review systematically examines the antibacterial activity of 459 plant-derived compounds, with a focus on 183 compounds that show promising potential as antibiotics. The rich chemodiversity and clinical effectiveness of plant NPs make them a valuable resource for future antibiotic discovery and development efforts.
Article
Chemistry, Organic
Akira Ebihara, Arihiro Iwasaki, Youhei Miura, Ghulam Jeelani, Tomoyoshi Nozaki, Kiyotake Suenaga
Summary: The new polyhalogenated aryl sulfates, Bromoiesol sulfates A and B, were isolated from a marine cyanobacterium and their structures were elucidated using Small Molecule Accurate Recognition Technology and X-ray diffraction analysis. Total synthesis of Bromoiesol A sulfate and Bromoiesol A was achieved, and their inhibitory effects on Trypanosoma brucei rhodesiense were confirmed.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Multidisciplinary Sciences
Dake Liu, Garret M. Rubin, Dipesh Dhakal, Manyun Chen, Yousong Ding
Summary: Peptidic natural products (PNPs) serve as a valuable source of lead compounds for drug discovery, but their chemical synthesis faces challenges such as the unavailability of constituent amino acids. Advances in biosynthesis and biocatalysis offer a promising alternative for the synthesis of PNPs.
Review
Chemistry, Medicinal
Fahimeh Nourbakhsh, Marzieh Lotfalizadeh, Mohaddeseh Badpeyma, Abolfazl Shakeri, Vahid Soheili
Summary: The bacterial membrane serves as a barrier that provides a cytoplasmic environment for organelles of bacteria and facilitates intercellular transfers of chemicals. Various antimicrobials have been identified to disrupt bacterial cytoplasmic membranes, potentially leading to cell death. Natural antimicrobial compounds have emerged as a promising alternative to antibiotics due to their lower side effects, cost-effectiveness, and biocompatibility, but further research is needed to validate their clinical efficacy.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Camila Irabuena, Laura Posada, Luciana Rey, Laura Scarone, Danilo Davyt, Juana Villalba, Gloria Serra
Summary: Cyclotetrapeptides analogues of tentoxin and versicotide D were synthesized in good yield using solid phase peptide synthesis (SPPS) and solution phase cyclization. Some compounds showed significant herbicidal activity by inhibiting Ryegrass seed's radicle growth. The peptide sequence, amino acid stereochemistry, and presence of N-methyl group were found to influence phytotoxic activity, with some compounds showing more improved activity than the natural products. Several compounds could be considered as lead candidates in the development of bioherbicides.
Article
Chemistry, Organic
Trevor C. Johnson, Mitchell P. Christy, Dionicio Siegel
Summary: The increased resistance of bacteria to clinical antibiotics is a major challenge in human health, and thiopeptide natural products show promising antibiotic activities. Synthetic methods for the core structure of thiopeptide natural products have been developed, enabling the large-scale synthesis of key intermediates.
SYNTHESIS-STUTTGART
(2021)
Review
Pharmacology & Pharmacy
Cheorl-Ho Kim
Summary: Research on COVID-19 is focused on collaborative searches for effective drugs, with current exploration into various treatment methods including drug screening and vaccine development. Studies have also found that SARS-CoV-2 infects host cells by recognizing specific neuraminic acids and membrane proteins.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Wenqin Li, Yi Ding, Huitang Qi, Tian Liu, Qing Yang
Summary: The study found that several phytochemicals can inhibit multiple insect chitinolytic enzymes simultaneously, with predicted interactions with key residues and good insecticidal activity. This research provides a new approach for using a multitarget high-throughput screening strategy to discover natural products as insecticide leads.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Infectious Diseases
Zeinab Breijyeh, Rafik Karaman
Summary: The need for innovative antimicrobials has increased due to the spread of multidrug-resistant bacteria. Overuse, abuse, and misuse of antibiotics are linked to antibiotic resistance. This paper reviews various approaches to develop novel classes of antibiotics with no pre-existing resistance in bacterial pathogens. These include nanotechnology, computational methods, antibiotic alternatives, drug repurposing, synthesis of novel antibacterial agents, and prodrugs. Regulations, public education, research, and technological advancements are crucial in combating antibiotic resistance.
Article
Chemistry, Multidisciplinary
Georg Niggemeyer, Anastasia Knyazeva, Raphael Gasper, Dale Corkery, Pia Bodenbinder, Julian J. Holstein, Sonja Sievers, Yao-Wen Wu, Herbert Waldmann
Summary: Design and synthesis of pseudo-natural products through recombination of natural product fragments enables the discovery of novel biologically relevant chemical matter. In this study, the combination of this principle with macrocycle formation was described, leading to the efficient synthesis of 163 macrocyclic pseudo-natural products. Biological investigation revealed their potent inducers of autophagy-related processes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biochemistry & Molecular Biology
Yalda Khazaei-poul, Shohreh Farhadi, Sepideh Ghani, Safar Ali Ahmadizad, Javad Ranjbari
Summary: Peptides are versatile tools in biological fields and can be used for various purposes, such as drug design, diagnostics, vaccines, and agriculture. Cyclic peptides, in particular, offer advantages like selective binding, higher potency, and stability compared to linear peptides. This paper provides an overview of the categories, synthesis methods, and diverse applications of cyclic peptides, including their roles as pro-apoptotic and anti-microbial agents, targeting ligands in drug delivery, and in agricultural and therapeutic applications.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Review
Infectious Diseases
Isabel Tobin, Guolong Zhang
Summary: The rise of antimicrobial resistance has led to an urgent need for antibiotic alternatives in disease control and prevention. Host defense peptides (HDPs), with their antimicrobial and immunomodulatory properties, offer a promising solution to treating infections without the risk of developing resistance. Polyphenols, natural compounds found in plants, have been found to stimulate HDP synthesis and show potential as antibiotic alternatives.
Review
Biochemistry & Molecular Biology
Jin-Ying Liu, Hong-Yan Guo, Zhe-Shan Quan, Qing-Kun Shen, Hong Cui, Xiaoting Li
Summary: Alzheimer's disease (AD), a persistent neurological dysfunction, is increasingly common with aging and poses a serious threat to the health of the elderly. Despite the lack of effective treatment for AD, researchers continue to explore its pathogenesis and potential therapeutic drugs. Natural products have gained attention due to their unique advantages, as one molecule can interact with multiple AD-related targets, making them potential candidates for multi-target drugs. Natural products and their derivatives that can alleviate pathological changes in AD should be intensively studied. This review focuses on research on natural products and their derivatives for the treatment of AD.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Yue Du, Yongliang Yuan, Le Xu, Fang Zhao, Wenbin Wang, Yiping Xu, Xin Tian
Summary: This study identified quercetin as a METTL3 inhibitor from natural products, providing a basis for further research and drug development targeting METTL3 for diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Sheo B. Singh, David E. Kaelin, Jin Wu, Lynn Miesel, Christopher M. Tan, Todd Black, Ravi Nargund, Peter T. Meinke, David B. Olsen, Armando Lagrutta, Jun Lu, Sangita Patel, Keith W. Rickert, Robert F. Smith, Stephen Soisson, Edward Sherer, Leo A. Joyce, Changqing Wei, Xuanjia Peng, Xiu Wang, Hideyuki Fukuda, Ryuta Kishii, Masaya Takei, Hisashi Takano, Mitsuhito Shibasaki, Masanobu Yajima, Akinori Nishimura, Takeshi Shibata, Yasumichi Fukuda
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2015)
Article
Endocrinology & Metabolism
Stephen F. Previs, Kithsiri Herath, Andrea R. Nawrocki, Carlos G. Rodriguez, Deborah Slipetz, Sheo B. Singh, Ling Kang, Gown Bhat, Thomas P. Roddy, Stacey Conarello, Jenna Terebetski, Mark D. Erion, David E. Kelley
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2018)
Article
Biotechnology & Applied Microbiology
Hiranthi Jayasuriya, Deborah Zink, Angela Basilio, Francisca Vicente, Javier Collado, Gerald Bills, Mary Lee Goldman, Mary Motyl, Joann Huber, Gabe Dezeny, Kevin Byrne, Sheo B. Singh
JOURNAL OF ANTIBIOTICS
(2009)
Article
Biotechnology & Applied Microbiology
Sloan Ayers, Deborah L. Zink, Kenneth Mohn, Joanne S. Powell, Christine M. Brown, Gerald Bills, Alan Grund, Donald Thompson, Sheo B. Singh
JOURNAL OF ANTIBIOTICS
(2010)
Article
Plant Sciences
Sloan Ayers, Deborah L. Zink, Joanne S. Powell, Christine M. Brown, Alan Grund, Gerald F. Bills, Gonzalo Platas, Donald Thompson, Sheo B. Singh
JOURNAL OF NATURAL PRODUCTS
(2008)
Article
Plant Sciences
Chaowei Zhang, Kithsiri Herath, Hiranthi Jayasuriya, John G. Ondeyka, Deborah L. Zink, James Occi, Gwyneth Birdsall, Jayashree Venugopal, Misti Ushio, Bruce Burgess, Prakash Masurekar, John F. Barrett, Sheo B. Singh
JOURNAL OF NATURAL PRODUCTS
(2009)
Article
Plant Sciences
Sheo B. Singh, Deborah L. Zink, Karen Dorso, Mary Motyl, Oscar Salazar, Angela Basilio, Francisca Vicente, Kevin M. Byrne, Sookhee Ha, Olga Genilloud
JOURNAL OF NATURAL PRODUCTS
(2009)
Article
Chemistry, Multidisciplinary
Gary E. Martin, Alexei V. Buevich, Mikhail Reibarkh, Sheo B. Singh, John G. Ondeyka, R. Thomas Williamson
MAGNETIC RESONANCE IN CHEMISTRY
(2013)
Article
Plant Sciences
Kithsiri B. Herath, Stephen F. Previs, Thomas P. Roddy, Athula B. Attygalle, Ignacio Gonzalez, Olga Genilloud, Sheo B. Singh
Summary: Natural product congeners play an important role in understanding biosynthesis and structure-activity relationships, but there is currently a lack of effective methods to rapidly, specifically, and selectively discover targeted congeners. A new method based on liquid-chromatography tandem-mass spectrometry combination has been successfully used for targeted discovery of congeners of platensimycin and platencin from Streptomyces platensis extracts, providing an efficient approach for congener research and discovery.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Plant Sciences
Sheo B. Singh
Summary: Dolastatin 10 is a highly potent broad-spectrum antitubulin anticancer pentapeptide isolated from Dolabellaauricularia. It can be modified at the C- and N-terminals to enhance its cytotoxic activity. However, clinical trials showed limited efficacy due to the lack of separation between toxicity and efficacy. Transitioning to antibody drug conjugates (ADCs) reduced systemic toxicity and several ADC drugs have been approved for cancer treatment.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Sheo B. Singh, Lynn Miesel, Susanne Kramer, Libo Xu, Fangbio Li, Jing Lan, Phillip Lipari, Jon D. Polishook, Gongjie Liu, Lianzhu Liang, Amy M. Flattery
Summary: Clostridioides difficile is a commensal gut bacterium that causes C. difficile-associated diarrhea. Current treatments for this condition are effective but prone to recurrence. Developing new therapies and effective antibiotics has been challenging. Nocathiacins and thiazomycins are thiazolyl peptides that show potent and selective activity against C. difficile. They have demonstrated strong efficacy and no systemic absorption.
JOURNAL OF NATURAL PRODUCTS
(2022)
Review
Biochemistry & Molecular Biology
Sheo B. Singh
Summary: Bioassay-guided purification of Combretum caffrum extracts led to the discovery of combretastatins A-D, which showed cytotoxic activities against a wide range of cancer cell lines. Among these, combretastatins A-4 and A-1 exhibited the most potent in vivo efficacy against various tumor types. These compounds inhibited tumor growth by reversibly binding to colchicine binding sites and stopping blood flow to the blood vessels, leading to necrosis. Clinical trials with the prodrugs of combretastatin A-4 and A-1 showed positive and stable responses in many tumor types, but further improvements are needed.
NATURAL PRODUCT REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Sheo B. Singh, James Occi, Hiranthi Jayasuriya, Kithsiri Herath, Mary Motyl, Karen Dorso, Charles Gill, Emily Hickey, Karen M. Overbye, John F. Barrett, Prakash Masurekar
JOURNAL OF ANTIBIOTICS
(2007)
Article
Biotechnology & Applied Microbiology
Hiranthi Jayasuriya, Kithsiri Herath, John G. Ondeyka, Chaowei Zhang, Deborah L. Zink, Mark Brower, Francis P. Gailliot, Joyce Greene, Gwyneth Birdsall, Jayashree Venugopal, Misti Ushio, Bruce Burgess, Greg Russotti, Andre Walker, Michelle Hesse, Anna Seeley, Beth Junker, Neal Connors, Oscar Salazar, Olga Genilloud, Kun Liu, Prakash Masurekar, John F. Barrett, Sheo B. Singh
JOURNAL OF ANTIBIOTICS
(2007)