期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 3, 页码 665-669出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.12.054
关键词
Phenylalanyl-tRNA synthetase; PheRS; FRS; Aminoacyl-tRNA synthetase; Benzyl phenyl ether; Antibacterial; SAR
A series of benzyl phenyl ethers (BPEs) is described that displays potent inhibition of bacterial phenylalanyl-tRNA synthetase. The synthesis, SAR, and select ADMET data are provided. (c) 2008 Elsevier Ltd. All rights reserved.
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