PDE4 as a target for cognition enhancement

HCN channels: Function and clinical implications

(2013) E. E. Benarroch   NEUROLOGY

The Phosphodiesterase-4 (PDE4) Inhibitor Rolipram Decreases Ethanol Seeking and Consumption in Alcohol-Preferring Fawn-Hooded Rats

(2012) Rui-Ting Wen et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Role of Epac in brain and heart

(2012) Anne-Coline Laurent et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects

(2012) Zhen-Zhen Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

PDE Inhibition and cognition enhancement

(2012) Arjan Blokland et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

A new model ofPde4ddeficiency: genetic knock-down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects

(2012) T. L. Schaefer et al.   GENES BRAIN AND BEHAVIOR

Cyclic Adenosine Monophosphate Phosphodiesterase Type 4 Protects Against Atrial Arrhythmias

(2012) Cristina E. Molina et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Comparison of cAMP-specific phosphodiesterase mRNAs distribution in mouse and rat brain

(2012) Emily M. Johansson et al.   NEUROSCIENCE LETTERS

Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats

(2012) Vivek Sharma et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

A Biphasic and Brain-Region Selective Down-Regulation of Cyclic Adenosine Monophosphate Concentrations Supports Object Recognition in the Rat

(2012) Maïte Hotte et al.   PLoS One

The Therapeutic Profile of Rolipram, PDE Target and Mechanism of Action as a Neuroprotectant following Spinal Cord Injury

(2012) Sandra Marie Schaal et al.   PLoS One

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

(2012) Jose Miguel Rubio-Perez et al.   TheScientificWorldJOURNAL

PDE4 inhibition enhances hippocampal synaptic plasticity in vivo and rescues MK801-induced impairment of long-term potentiation and object recognition memory in an animal model of psychosis

(2012) V Wiescholleck et al.   Translational Psychiatry

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses

(2011) O Bruno et al.   BRITISH JOURNAL OF PHARMACOLOGY

Can small molecules provide truly effective enhancement of cognition? Current achievements and future directions

(2011) Niels Plath et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease

(2011) Albert Giralt et al.   HUMAN MOLECULAR GENETICS

The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats

(2011) Chuang Wang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function

(2011) H. Murdoch et al.   JOURNAL OF CELL SCIENCE

Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice

(2011) Jérôme Leroy et al.   JOURNAL OF CLINICAL INVESTIGATION

Stimulation of bursting in pre-Bötzinger neurons by Epac through calcium release and modulation of TRPM4 and K-ATP channels

(2011) Sergej L. Mironov et al.   JOURNAL OF NEUROCHEMISTRY

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

(2011) Y.-F. Li et al.   JOURNAL OF NEUROSCIENCE

Prevention of cerebral ischemia-induced memory deficits by inhibition of phosphodiesterase-4 in rats

(2011) Ling-Xia Li et al.   METABOLIC BRAIN DISEASE

Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout (PDE4B−/−) mice

(2011) Kris Rutten et al.   NEUROPHARMACOLOGY

Inhibition of phosphodiesterase-4 decreases ethanol intake in mice

(2011) Wei Hu et al.   PSYCHOPHARMACOLOGY

Identification of pyridazino[4,5-b]indolizines as selective PDE4B inhibitors

(2010) Andrew F. Donnell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyrazolopyridines as potent PDE4B inhibitors: 5-Heterocycle SAR

(2010) Charlotte J. Mitchell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors

(2010) Renee Aspiotis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment

(2010) Michel Gallant et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New perspectives in cyclic AMP-mediated axon growth and guidance: The emerging epoch of Epac

(2010) Andrew G. Peace et al.   BRAIN RESEARCH BULLETIN

Strategy for effective brain drug delivery

(2010) M. Intakhab Alam et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Phosphodiesterase 4B is essential for TH2-cell function and development of airway hyperresponsiveness in allergic asthma

(2010) S.-L. Catherine Jin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

(2010) F. Mori et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25–35 or Aβ1–40 peptide in rats

(2010) Yu-Fang Cheng et al.   PSYCHOPHARMACOLOGY

Drug Addiction and the Memory Systems of the Brain

(2009) T.W. Robbins et al.   Annals of the New York Academy of Sciences

Association Between Genes of Disrupted in Schizophrenia 1 (DISC1) Interactors and Schizophrenia Supports the Role of the DISC1 Pathway in the Etiology of Major Mental Illnesses

(2009) Liisa Tomppo et al.   BIOLOGICAL PSYCHIATRY

Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode

(2009) Michael Kranz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of selective PDE4B inhibitors

(2009) Kenji Naganuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Various drug delivery approaches to the central nervous system

(2009) Santosh Pasha et al.   Expert Opinion on Drug Delivery

Emerging cognitive enhancing drugs

(2009) Jerry J Buccafusco   EXPERT OPINION ON EMERGING DRUGS

Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval

(2009) Anghelus Ostroveanu et al.   HIPPOCAMPUS

Differential Association of Phosphodiesterase 4D Isoforms with β2-Adrenoceptor in Cardiac Myocytes

(2009) Vania De Arcangelis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials

(2009) Leonardo M Fabbri et al.   LANCET

Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials

(2009) Peter MA Calverley et al.   LANCET

Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A

(2009) N. Ma et al.   LEARNING & MEMORY

Sleep deprivation impairs cAMP signalling in the hippocampus

(2009) Christopher G. Vecsey et al.   NATURE

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Antidepressant- and Anxiolytic-like Effects of the Phosphodiesterase-4 Inhibitor Rolipram on Behavior Depend on Cyclic AMP Response Element Binding Protein-Mediated Neurogenesis in the Hippocampus

(2009) Yun-Feng Li et al.   NEUROPSYCHOPHARMACOLOGY

Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia

(2009) Anjali Rastogi et al.   SCHIZOPHRENIA RESEARCH

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change

(2008) Kirsty F. Mackenzie et al.   BIOCHEMICAL JOURNAL

Getting into the Brain

(2008) Mayur M Patel et al.   CNS DRUGS

Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4

(2008) Wito Richter et al.   EMBO JOURNAL

Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout (PDE4D−/−) mice

(2008) Kris Rutten et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Critical Role of PDE4D in β2-Adrenoceptor-dependent cAMP Signaling in Mouse Embryonic Fibroblasts

(2008) Matthew D. Bruss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Application of an Epac Activator Enhances Neurotransmitter Release at Excitatory Central Synapses

(2008) I. Gekel et al.   JOURNAL OF NEUROSCIENCE

Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population

(2008) Shusuke Numata et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus

(2008) J. N. Gelinas et al.   LEARNING & MEMORY

Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease

(2008) Zena DeMarch et al.   NEUROBIOLOGY OF DISEASE

Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats

(2008) M.N. de Lima et al.   NEUROPHARMACOLOGY

Phosphodiesterase-4A expression is reduced in cerebella of patients with bipolar disorder

(2008) S. Hossein Fatemi et al.   PSYCHIATRIC GENETICS

PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia

(2008) S. Hossein Fatemi et al.   SCHIZOPHRENIA RESEARCH