Role of Epac in brain and heart

Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications

(2011) Magali Breckler et al.   CELLULAR SIGNALLING

Stimulation of bursting in pre-Bötzinger neurons by Epac through calcium release and modulation of TRPM4 and K-ATP channels

(2011) Sergej L. Mironov et al.   JOURNAL OF NEUROCHEMISTRY

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties

(2010) S. Sehrawat et al.   BLOOD

Epac activation induces histone deacetylase nuclear export via a Ras-dependent signalling pathway

(2010) Mélanie Métrich et al.   CELLULAR SIGNALLING

Differential Roles of Epac in Regulating Cell Death in Neuronal and Myocardial Cells

(2010) Sayaka Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low Nociceptor GRK2 Prolongs Prostaglandin E2 Hyperalgesia via Biased cAMP Signaling to Epac/Rap1, Protein Kinase C , and MEK/ERK

(2010) N. Eijkelkamp et al.   JOURNAL OF NEUROSCIENCE

A Model for Sealing Plasmalemmal Damage in Neurons and Other Eukaryotic Cells

(2010) C. S. Spaeth et al.   JOURNAL OF NEUROSCIENCE

Epac2-mediated dendritic spine remodeling: Implications for disease

(2010) Peter Penzes et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Epac stimulation induces rapid increases in connexin43 phosphorylation and function without preconditioning effect

(2010) Nicolas Duquesnes et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Regulation of cardiac fibroblast collagen synthesis by adenosine: roles for Epac and PI3K

(2009) Francisco Villarreal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

EPAC proteins transduce diverse cellular actions of cAMP

(2009) Gillian Borland et al.   BRITISH JOURNAL OF PHARMACOLOGY

Urocortin induces positive inotropic effect in rat heart

(2009) Eva Calderón-Sanchez et al.   CARDIOVASCULAR RESEARCH

Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval

(2009) Anghelus Ostroveanu et al.   HIPPOCAMPUS

Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function

(2009) Manabu Niimura et al.   JOURNAL OF CELLULAR PHYSIOLOGY

cAMP-Dependent Axon Guidance Is Distinctly Regulated by Epac and Protein Kinase A

(2009) A. J. Murray et al.   JOURNAL OF NEUROSCIENCE

Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A

(2009) N. Ma et al.   LEARNING & MEMORY

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

(2009) Kevin M Woolfrey et al.   NATURE NEUROSCIENCE

Role of the cAMP-binding protein Epac in cardiovascular physiology and pathophysiology

(2009) Mélanie Métrich et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The cAMP binding protein Epac regulates cardiac myofilament function

(2009) O. Cazorla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways

(2008) Hyun-Jeong Kwak et al.   CELLULAR SIGNALLING

Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation

(2008) Ingrid M. Nijholt et al.   CELLULAR SIGNALLING

Epac Mediates β-Adrenergic Receptor–Induced Cardiomyocyte Hypertrophy

(2008) Mélanie Métrich et al.   CIRCULATION RESEARCH

Epac and Phospholipase Cϵ Regulate Ca2+Release in the Heart by Activation of Protein Kinase Cϵ and Calcium-Calmodulin Kinase II

(2008) Emily A. Oestreich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Application of an Epac Activator Enhances Neurotransmitter Release at Excitatory Central Synapses

(2008) I. Gekel et al.   JOURNAL OF NEUROSCIENCE

Epac mediates PACAP-dependent long-term depression in the hippocampus

(2008) Jeanne Ster et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus

(2008) J. N. Gelinas et al.   LEARNING & MEMORY

Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration

(2008) Andrew J. Murray et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Gαs, a G-protein subunit genetically linked to schizophrenia

(2008) M P Kelly et al.   MOLECULAR PSYCHIATRY

Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart

(2008) Sandeep S. Hothi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals

(2008) U. Yokoyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epac signaling is required for hippocampus-dependent memory retrieval

(2008) M. Ouyang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cAMP-Dependent Signaling as a Core Component of the Mammalian Circadian Pacemaker

(2008) J. S. O'Neill et al.   SCIENCE