The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats

Neurotrophins Enhance CaMKII Activity and Rescue Amyloid-β-Induced Deficits in Hippocampal Synaptic Plasticity

(2017) Yan Zeng et al.   JOURNAL OF ALZHEIMERS DISEASE

Molecular Network Analysis Suggests Aberrant CREB-Mediated Gene Regulation in the Alzheimer Disease Hippocampus

(2013) Jun-ichi Satoh et al.   DISEASE MARKERS

Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

(2012) Paula Agostinho et al.   CURRENT PHARMACEUTICAL DESIGN

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

(2011) Y.-F. Li et al.   JOURNAL OF NEUROSCIENCE

S-propargyl-cysteine (ZYZ-802), a sulphur-containing amino acid, attenuates beta-amyloid-induced cognitive deficits and pro-inflammatory response: involvement of ERK1/2 and NF-κB pathway in rats

(2010) Qi-Hai Gong et al.   AMINO ACIDS

Attenuation of NF-κB and activation of Nrf2 signaling by 1,2,4-triazine derivatives, protects neuron-like PC12 cells against apoptosis

(2010) Solaleh Khoramian Tusi et al.   APOPTOSIS

Identification of pyridazino[4,5-b]indolizines as selective PDE4B inhibitors

(2010) Andrew F. Donnell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Leptin enhances growth inhibition by cAMP elevating agents through apoptosis of MDA-MB-231 breast cancer cells

(2010) Silvio Naviglio et al.   CANCER BIOLOGY & THERAPY

Anti-inflammatory activity of phosphodiesterase (PDE)-IV inhibitors in acute and chronic models of inflammation

(2010) L. SEKUT et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immune-Inflammatory Responses and Oxidative Stress in Alzheimers Disease: Therapeutic Implications

(2010) D. Bona et al.   CURRENT PHARMACEUTICAL DESIGN

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adiponectin inhibits palmitate-induced apoptosis through suppression of reactive oxygen species in endothelial cells: involvement of cAMP/protein kinase A and AMP-activated protein kinase

(2010) Ji-Eun Kim et al.   JOURNAL OF ENDOCRINOLOGY

Active Immunization with Amyloid-  1-42 Impairs Memory Performance through TLR2/4-Dependent Activation of the Innate Immune System

(2010) P. Vollmar et al.   JOURNAL OF IMMUNOLOGY

PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-κB-independent manner

(2010) Lirlândia P. Sousa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammatory, Apoptotic, and Survival Gene Signaling in Alzheimer’s Disease

(2010) Walter J. Lukiw et al.   MOLECULAR NEUROBIOLOGY

Membrane Biophysics and Mechanics in Alzheimer's Disease

(2010) Xiaoguang Yang et al.   MOLECULAR NEUROBIOLOGY

Apoptosis Inhibition Can Be Threatening in Aβ-Induced Neuroinflammation, Through Promoting Cell Proliferation

(2010) A. Abdi et al.   NEUROCHEMICAL RESEARCH

Val8-glucagon-like peptide-1 protects against Aβ1–40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats

(2010) X.H. Wang et al.   NEUROSCIENCE

Effects of trans-2,4-dimethoxystibene against the neurotoxicity induced by Aβ25–35 both in vitro and in vivo

(2010) Can-Jun Ruan et al.   NEUROSCIENCE RESEARCH

Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25–35 or Aβ1–40 peptide in rats

(2010) Yu-Fang Cheng et al.   PSYCHOPHARMACOLOGY

Discovery of selective PDE4B inhibitors

(2009) Kenji Naganuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activation of cAMP signaling inhibits DNA damage-induced apoptosis in BCP-ALL cells through abrogation of p53 accumulation

(2009) E. H. Naderi et al.   BLOOD

Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs

(2009) Han-Ting Zhang   CURRENT PHARMACEUTICAL DESIGN

Sleep deprivation impairs cAMP signalling in the hippocampus

(2009) Christopher G. Vecsey et al.   NATURE

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Antidepressant- and Anxiolytic-like Effects of the Phosphodiesterase-4 Inhibitor Rolipram on Behavior Depend on Cyclic AMP Response Element Binding Protein-Mediated Neurogenesis in the Hippocampus

(2009) Yun-Feng Li et al.   NEUROPSYCHOPHARMACOLOGY

Pharmacology of a Novel, Orally Active PDE4 Inhibitor

(2009) Sunanda G. Dastidar et al.   PHARMACOLOGY

Memory deficits and neurochemical changes induced by C-reactive protein in rats: implication in Alzheimer’s disease

(2009) Huan-Bing Lin et al.   PSYCHOPHARMACOLOGY

Sub-chronic rolipram treatment leads to a persistent improvement in long-term object memory in rats

(2008) K. Rutten et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The effects of acute and repeated oroxylin A treatments on Aβ25–35-induced memory impairment in mice

(2008) Dong Hyun Kim et al.   NEUROPHARMACOLOGY

Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease

(2007) Leonel E. Rojo et al.   ARCHIVES OF MEDICAL RESEARCH

Aβ(1–42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT2A levels

(2007) R. Christensen et al.   EXPERIMENTAL NEUROLOGY