GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

(2011) Y.-F. Li et al.   JOURNAL OF NEUROSCIENCE

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D

(2010) F. Mori et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25–35 or Aβ1–40 peptide in rats

(2010) Yu-Fang Cheng et al.   PSYCHOPHARMACOLOGY

Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs

(2009) Han-Ting Zhang   CURRENT PHARMACEUTICAL DESIGN

New Selective Phosphodiesterase 4D Inhibitors Differently Acting on Long, Short, and Supershort Isoforms

(2009) Olga Bruno et al.   JOURNAL OF MEDICINAL CHEMISTRY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

(2009) Tim Vanmierlo et al.   NEUROBIOLOGY OF AGING

Phosphodiesterase Inhibitors Enhance Object Memory Independent of Cerebral Blood Flow and Glucose Utilization in Rats

(2009) Kris Rutten et al.   NEUROPSYCHOPHARMACOLOGY

Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout (PDE4D−/−) mice

(2008) Kris Rutten et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Potential of the rat model of conditioned gaping to detect nausea produced by rolipram, a phosphodiesterase-4 (PDE4) inhibitor

(2008) Erin M. Rock et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement

(2008) Olga A. H. Reneerkens et al.   PSYCHOPHARMACOLOGY