标题
Modern Subunit Vaccines: Development, Components, and Research Opportunities
作者
关键词
-
出版物
ChemMedChem
Volume 8, Issue 3, Pages 360-376
出版商
Wiley
发表日期
2013-01-12
DOI
10.1002/cmdc.201200487
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- TLR9 agonist CpG enhances protective nasal HSP60 peptide vaccine efficacy in experimental autoimmune arthritis
- (2012) Evelien Zonneveld-Huijssoon et al. ANNALS OF THE RHEUMATIC DISEASES
- Pattern recognition receptors: sentinels in innate immunity and targets of new vaccine adjuvants
- (2012) Colleen Olive Expert Review of Vaccines
- The current challenges for vaccine development
- (2012) P. Oyston et al. JOURNAL OF MEDICAL MICROBIOLOGY
- Therapeutic Cancer Vaccines: Current Status and Moving Forward
- (2012) J. Schlom JNCI-Journal of the National Cancer Institute
- Reverse vaccinology on the cusp
- (2012) Dan Jones NATURE REVIEWS DRUG DISCOVERY
- Synthetic Toll Like Receptor-4 (TLR-4) Agonist Peptides as a Novel Class of Adjuvants
- (2012) Arulkumaran Shanmugam et al. PLoS One
- A Double-Blind, Placebo-Controlled, Randomized, Clinical Trial of the TLR-3 Agonist Rintatolimod in Severe Cases of Chronic Fatigue Syndrome
- (2012) David R. Strayer et al. PLoS One
- Immunological Evaluation of Lipopeptide Group A Streptococcus (GAS) Vaccine: Structure-Activity Relationship
- (2012) Mehfuz Zaman et al. PLoS One
- AS03 Adjuvanted AH1N1 Vaccine Associated with an Abrupt Increase in the Incidence of Childhood Narcolepsy in Finland
- (2012) Hanna Nohynek et al. PLoS One
- Structural Basis of TLR5-Flagellin Recognition and Signaling
- (2012) S.-i. Yoon et al. SCIENCE
- Simultaneous Targeting of Toll- and Nod-Like Receptors Induces Effective Tumor-Specific Immune Responses
- (2012) J. Garaude et al. Science Translational Medicine
- Recombinant protein vaccines produced in insect cells
- (2012) Manon M.J. Cox VACCINE
- Virus-like particles as a highly efficient vaccine platform: Diversity of targets and production systems and advances in clinical development
- (2012) Natasha Kushnir et al. VACCINE
- A totally synthetic lipopeptide-based self-adjuvanting vaccine induces neutralizing antibodies against heat-stable enterotoxin from enterotoxigenic Escherichia coli
- (2012) Weiguang Zeng et al. VACCINE
- Structural Biology of the Toll-Like Receptor Family
- (2011) Jin Young Kang et al. Annual Review of Biochemistry
- Universal vaccines: shifting to one for many or shooting too high too soon!
- (2011) MAWIEH HAMAD APMIS
- Mannosylated Dextran Nanoparticles: A pH-Sensitive System Engineered for Immunomodulation through Mannose Targeting
- (2011) Lina Cui et al. BIOCONJUGATE CHEMISTRY
- Simple synthetic toll-like receptor 2 ligands
- (2011) Abu-Baker M. Abdel-Aal et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Toward self-adjuvanting subunit vaccines: Model peptide and protein antigens incorporating covalently bound toll-like receptor-7 agonistic imidazoquinolines
- (2011) Nikunj M. Shukla et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Vaccines Against Drug Abuse
- (2011) X Y Shen et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- License to kill: Formulation requirements for optimal priming of CD8+ CTL responses with particulate vaccine delivery systems
- (2011) Camilla Foged et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- AE37: a novel T-cell-eliciting vaccine for breast cancer
- (2011) Alan K Sears et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- TLR-7 and -8 agonists as vaccine adjuvants
- (2011) Mark A Tomai et al. Expert Review of Vaccines
- Respiratory syncytial virus vaccine development
- (2011) Julia L Hurwitz Expert Review of Vaccines
- Peptidomimetics: modifying peptides in the pursuit of better vaccines
- (2011) Nathan P Croft et al. Expert Review of Vaccines
- CpG DNA as a vaccine adjuvant
- (2011) Christian Bode et al. Expert Review of Vaccines
- Toll-like receptor-mediated adjuvanticity and immunomodulation in dendritic cells: Implications for peptide vaccines
- (2011) Daniel Mitchell et al. Human vaccines & immunotherapeutics
- Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity
- (2011) Taro Kawai et al. IMMUNITY
- Pathogen Recognition by the Innate Immune System
- (2011) Himanshu Kumar et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- A Modular Approach to Assembly of Totally Synthetic Self-adjuvanting Lipopeptide-based Vaccines Allows Conformational Epitope Building
- (2011) Weiguang Zeng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A new cloning system based on the OprI lipoprotein for the production of recombinant bacterial cell wall-derived immunogenic formulations
- (2011) Afonso P. Basto et al. JOURNAL OF BIOTECHNOLOGY
- Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets
- (2011) Kathrin Kastenmüller et al. JOURNAL OF CLINICAL INVESTIGATION
- MHC Class II Epitope Nesting Modulates Dendritic Cell Function and Improves Generation of Antigen-Specific CD4 Helper T Cells
- (2011) C. L. Erskine et al. JOURNAL OF IMMUNOLOGY
- Soluble Proteins Induce Strong CD8+ T Cell and Antibody Responses through Electrostatic Association with Simple Cationic or Anionic Lipopeptides That Target TLR2
- (2011) B. Y. Chua et al. JOURNAL OF IMMUNOLOGY
- Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity
- (2011) C. Trumpfheller et al. JOURNAL OF INTERNAL MEDICINE
- Alum adjuvant: some of the tricks of the oldest adjuvant
- (2011) M. Kool et al. JOURNAL OF MEDICAL MICROBIOLOGY
- Structure–Activity Relationships in Toll-Like Receptor 2-Agonists Leading to Simplified Monoacyl Lipopeptides
- (2011) Geetanjali Agnihotri et al. JOURNAL OF MEDICINAL CHEMISTRY
- Computational Design of High-Affinity Epitope Scaffolds by Backbone Grafting of a Linear Epitope
- (2011) Mihai L. Azoitei et al. JOURNAL OF MOLECULAR BIOLOGY
- Expression of an endotoxin-free S-layer/allergen fusion protein in gram-positive Bacillus subtilis 1012 for the potential application as vaccines for immunotherapy of atopic allergy
- (2011) Nicola Ilk et al. Microbial Cell Factories
- Mouse and human intestinal immunity: same ballpark, different players; different rules, same score
- (2011) D L Gibbons et al. Mucosal Immunology
- A 2020 vision for vaccines against HIV, tuberculosis and malaria
- (2011) Rino Rappuoli et al. NATURE
- Immunological mechanisms of vaccination
- (2011) Bali Pulendran et al. NATURE IMMUNOLOGY
- Heterologous Epitope-Scaffold Prime∶Boosting Immuno-Focuses B Cell Responses to the HIV-1 gp41 2F5 Neutralization Determinant
- (2011) Javier Guenaga et al. PLoS One
- Immunogenicity and Efficacy of Flagellin-Fused Vaccine Candidates Targeting 2009 Pandemic H1N1 Influenza in Mice
- (2011) Ge Liu et al. PLoS One
- Pathogen-associated molecular patterns on biomaterials: a paradigm for engineering new vaccines
- (2011) Stacey L. Demento et al. TRENDS IN BIOTECHNOLOGY
- Boosting antibody responses by targeting antigens to dendritic cells
- (2011) Irina Caminschi et al. TRENDS IN IMMUNOLOGY
- Experimental human pneumococcal carriage models for vaccine research
- (2011) Daniela M. Ferreira et al. TRENDS IN MICROBIOLOGY
- Structural modification effects on bioactivities of the novel 15-mer peptide adjuvant
- (2011) A.G. Laman et al. VACCINE
- Flagellin produced in plants is a potent adjuvant for oral immunization
- (2011) Aurélie Girard et al. VACCINE
- Vaccines of the future
- (2011) G.J.V. Nossal VACCINE
- Induction of a potent immune response in the elderly using the TLR-5 agonist, flagellin, with a recombinant hemagglutinin influenza–flagellin fusion vaccine (VAX125, STF2.HA1 SI)
- (2011) David N. Taylor et al. VACCINE
- Virus aggregating peptide enhances the cell-mediated response to influenza virus vaccine
- (2011) Jeremy C. Jones et al. VACCINE
- Safety and immunogenicity of a recombinant M2e–flagellin influenza vaccine (STF2.4xM2e) in healthy adults
- (2011) Christine B. Turley et al. VACCINE
- Vaccine adjuvant activity of 3M-052: An imidazoquinoline designed for local activity without systemic cytokine induction
- (2011) Dmitri Smirnov et al. VACCINE
- Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infection
- (2011) Seol Hee Hong et al. VACCINE
- The Virucidal EB Peptide Protects Host Cells from Herpes Simplex Virus Type 1 Infection in the Presence of Serum Albumin and Aggregates Proteins in a Detergent-Like Manner
- (2010) H. Bultmann et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Designing polymeric particles for antigen delivery
- (2010) Stefaan De Koker et al. CHEMICAL SOCIETY REVIEWS
- Results from a Phase I Clinical Study of the Novel Ii-Key/HER-2/neu(776-790) Hybrid Peptide Vaccine in Patients with Prostate Cancer
- (2010) S. A. Perez et al. CLINICAL CANCER RESEARCH
- TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity
- (2010) Shirdi E. Letran et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Advances in the design and delivery of peptide subunit vaccines with a focus on Toll-like receptor agonists
- (2010) Matthew Black et al. Expert Review of Vaccines
- Combination adjuvants: the next generation of adjuvants?
- (2010) George Mutwiri et al. Expert Review of Vaccines
- Immunoprofiling toll-like receptor ligands: Comparison of immunostimulatory and proinflammatory profiles in ex vivo human blood models
- (2010) Jennifer D. Hood et al. Human vaccines & immunotherapeutics
- Toll-like Receptor 2 Signaling in CD4+ T Lymphocytes Promotes T Helper 17 Responses and Regulates the Pathogenesis of Autoimmune Disease
- (2010) Joseph M. Reynolds et al. IMMUNITY
- Designing Vaccines Based on Biology of Human Dendritic Cell Subsets
- (2010) Karolina Palucka et al. IMMUNITY
- Reverse Vaccinology: Developing Vaccines in the Era of Genomics
- (2010) Alessandro Sette et al. IMMUNITY
- Vaccine Adjuvants: Putting Innate Immunity to Work
- (2010) Robert L. Coffman et al. IMMUNITY
- Use of defined TLR ligands as adjuvants within human vaccines
- (2010) Malcolm S. Duthie et al. IMMUNOLOGICAL REVIEWS
- TLR3 agonists as immunotherapeutic agents
- (2010) Christopher F Nicodemus et al. Immunotherapy
- Flagellin as an Adjuvant: Cellular Mechanisms and Potential
- (2010) S. B. Mizel et al. JOURNAL OF IMMUNOLOGY
- The Capacity To Induce Cross-Presentation Dictates the Success of a TLR7 Agonist-Conjugate Vaccine for Eliciting Cellular Immunity
- (2010) J. Z. Oh et al. JOURNAL OF IMMUNOLOGY
- Design of Three-Component Vaccines against Group A Streptococcal Infections: Importance of Spatial Arrangement of Vaccine Components
- (2010) Abu-Baker M. Abdel-Aal et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structure−Activity Relationships in Toll-like Receptor-2 Agonistic Diacylthioglycerol Lipopeptides
- (2010) Wenyan Wu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Lipidation of intact proteins produces highly immunogenic vaccine candidates
- (2010) Weiguang Zeng et al. MOLECULAR IMMUNOLOGY
- Carbohydrate vaccines: developing sweet solutions to sticky situations?
- (2010) Rena D. Astronomo et al. NATURE REVIEWS DRUG DISCOVERY
- Immunopotentiation of Trivalent Influenza Vaccine When Given with VAX102, a Recombinant Influenza M2e Vaccine Fused to the TLR5 Ligand Flagellin
- (2010) H. Keipp Talbot et al. PLoS One
- Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope
- (2010) Bruno E. Correia et al. STRUCTURE
- Circulating regulatory T cells (CD4+CD25+FOXP3+) decrease in breast cancer patients after vaccination with a modified MHC class II HER2/neu (AE37) peptide
- (2010) Jeremy D. Gates et al. VACCINE
- Structure–activity relationship of lipopeptide Group A streptococcus (GAS) vaccine candidates on toll-like receptor 2
- (2010) Mehfuz Zaman et al. VACCINE
- HMGB1-derived peptide acts as adjuvant inducing immune responses to peptide and protein antigen
- (2010) R. Saenz et al. VACCINE
- Safety and immunogenicity of a recombinant hemagglutinin influenza–flagellin fusion vaccine (VAX125) in healthy young adults
- (2010) John J. Treanor et al. VACCINE
- The potential of 3′,5′-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant
- (2010) Wangxue Chen et al. VACCINE
- A Recombinant Flagellin-Poxvirus Fusion Protein Vaccine Elicits Complement-Dependent Protection Against Respiratory Challenge with Vaccinia Virus in Mice
- (2010) Kristen N. Delaney et al. VIRAL IMMUNOLOGY
- IL-17 and Th17 Cells
- (2009) Thomas Korn et al. Annual Review of Immunology
- 3′,5′-Cyclic diguanylic acid elicits mucosal immunity against bacterial infection
- (2009) Hongbin Yan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Vaccines: the Fourth Century
- (2009) S. A. Plotkin Clinical and Vaccine Immunology
- Physicochemical characterization and biological activity of synthetic TLR4 agonist formulations
- (2009) Ryan C. Anderson et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- TLR2-activated human langerhans cells promote Th17 polarization via IL-1β, TGF-β and IL-23
- (2009) Ehsan Aliahmadi et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA
- (2009) Irving C. Allen et al. IMMUNITY
- Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer
- (2009) Jin Young Kang et al. IMMUNITY
- A novel synthetic adjuvant enhances dendritic cell function
- (2009) Karen S. M. Phillipps et al. IMMUNOLOGY
- Receptors and ligands implicated in human T cell costimulatory processes
- (2009) Judith Leitner et al. IMMUNOLOGY LETTERS
- TLR2 Promotes Th2/Th17 Responses via TLR4 and TLR7/8 by Abrogating the Type I IFN Amplification Loop
- (2009) M. H. Wenink et al. JOURNAL OF IMMUNOLOGY
- Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies
- (2009) Nicole O'Brien et al. JOURNAL OF LIPID RESEARCH
- A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge
- (2009) X Zhang et al. Mucosal Immunology
- Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa
- (2009) S A Khader et al. Mucosal Immunology
- The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex
- (2009) Beom Seok Park et al. NATURE
- Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand
- (2009) Supachai Rerks-Ngarm et al. NEW ENGLAND JOURNAL OF MEDICINE
- Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challenge
- (2009) M. Mohamadzadeh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A self-assembling peptide acting as an immune adjuvant
- (2009) J. S. Rudra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Immunoadjuvant capacity of flagellin and mannosamine-coated poly(anhydride) nanoparticles in oral vaccination
- (2009) Hesham H. Salman et al. VACCINE
- A novel technology for the production of a heterologous lipoprotein immunogen in high yield has implications for the field of vaccine design
- (2009) Hsin-Wei Chen et al. VACCINE
- CD8+ T cell adjuvant effects of Salmonella FliCd flagellin in live vaccine vectors or as purified protein
- (2009) Catarina J.M. Braga et al. VACCINE
- Inhibition of Vaccinia virus entry by a broad spectrum antiviral peptide
- (2009) S.E. Altmann et al. VIROLOGY
- TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆
- (2008) M MATSUMOTO et al. ADVANCED DRUG DELIVERY REVIEWS
- The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement
- (2008) I. Caminschi et al. BLOOD
- A phase II dose-ranging study of topical resiquimod to treat actinic keratosis
- (2008) R.-M. Szeimies et al. BRITISH JOURNAL OF DERMATOLOGY
- Total chemical synthesis of proteins
- (2008) Stephen B. H. Kent CHEMICAL SOCIETY REVIEWS
- Self-Adjuvanting Lipopeptide Vaccines
- (2008) Peter Moyle et al. CURRENT MEDICINAL CHEMISTRY
- A comparative analysis of cytokine responses, cell surface marker expression and MAPKs in DCs matured with LPS compared with a panel of TLR ligands
- (2008) David Dowling et al. CYTOKINE
- Enhanced Immunogenicity of Plasmodium falciparum Peptide Vaccines Using a Topical Adjuvant Containing a Potent Synthetic Toll-Like Receptor 7 Agonist, Imiquimod
- (2008) C. Othoro et al. INFECTION AND IMMUNITY
- Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5
- (2008) Hiroki Kato et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Efficacious Recombinant Influenza Vaccines Produced by High Yield Bacterial Expression: A Solution to Global Pandemic and Seasonal Needs
- (2008) Langzhou Song et al. PLoS One
- Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA
- (2008) L. Liu et al. SCIENCE
- Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold ‘em, knowing when to fold ‘em
- (2008) Matthew I. Hutchings et al. TRENDS IN MICROBIOLOGY
- Efficient immune responses against Intimin and EspB of enterohaemorragic Escherichia coli after intranasal vaccination using the TLR2/6 agonist MALP-2 as adjuvant
- (2008) Angel Cataldi et al. VACCINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started