Article
Immunology
Hossein Samiei, Shahram Nazarian, Abass Hajizade, Emad Kordbacheh
Summary: In this study, a chimeric protein comprising two antigens of Escherichia coli O157:H7 was designed and evaluated as a vaccine candidate using in silico techniques. The results showed that the proposed antigen has high antigenicity and conformation suitable for being a potent vaccine candidate. Immunization evaluation demonstrated that the protein is able to stimulate the immune responses of mice and provide protective immunity against E. coli O157:H7.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Agronomy
Yun-Lin Su, Mariano Larzabal, Huan Song, Tianfang Cheng, Yufang Wang, Libia Yael Smith, Angel Adrian Cataldi, David W. Ow
Summary: In a mouse study, oral vaccination using transgenic lettuce showed the potential to reduce colonization of the food-borne pathogen EHEC O157:H7 and induce a mucosal immune response. This suggests that transgenic lettuce could be used for bovine vaccination.
THEORETICAL AND APPLIED GENETICS
(2023)
Article
Immunology
Jinyi Tang, Cong Zeng, Thomas M. Cox, Chaofan Li, Young Min Son, In Su Cheon, Yue Wu, Supriya Behl, Justin J. Taylor, Rana Chakaraborty, Aaron J. Johnson, Dante N. Shiavo, James P. Utz, Janani S. Reisenauer, David E. Midthun, John J. Mullon, Eric S. Edell, Mohamad G. Alameh, Larry Borish, William G. Teague, Mark H. Kaplan, Drew Weissman, Ryan Kern, Haitao Hu, Robert Vassallo, Shan-Lu Liu, Jie Sun
Summary: SARS-CoV-2 mRNA vaccination induces strong immune responses in the circulation, but its effectiveness in the respiratory tract, especially against variants of concern like Omicron, is still uncertain. This study found lower neutralizing antibody responses in the respiratory tract of vaccinated individuals compared to COVID-19 convalescents, despite robust antibody responses in the blood. Vaccination also induced circulating B and T cell immunity, but these responses were absent in the respiratory tract. Mouse immunization experiments showed that systemic mRNA vaccination alone resulted in weak respiratory mucosal neutralizing antibody responses, but combining it with mucosal adenovirus-S immunization produced strong neutralizing antibody responses against both the ancestral virus and the Omicron variant. Overall, this study suggests that current COVID-19 vaccines are highly effective against severe disease, but provide limited protection against breakthrough infections, particularly by the Omicron sublineage.
SCIENCE IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Kaori Sano, Disha Bhavsar, Gagandeep Singh, Daniel Floda, Komal Srivastava, Charles Gleason, Juan Manuel Carreno, Viviana Simon, Florian Krammer
Summary: This study reveals that prior SARS-CoV-2 infection enhances the induction of mucosal SARS-CoV-2 secretory IgA antibody following mRNA vaccination, while individuals without prior exposure to the virus have a minimal mucosal antibody response.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Elena Mitsi, Mariana O. Diniz, Jesus Reine, Andrea M. Collins, Ryan E. Robinson, Angela Hyder-Wright, Madlen Farrar, Konstantinos Liatsikos, Josh Hamilton, Onyia Onyema, Britta C. Urban, Carla Solorzano, Sandra Belij-Rammerstorfer, Emma Sheehan, Teresa Lambe, Simon J. Draper, Daniela Weiskopf, Alessandro Sette, Mala K. Maini, Daniela M. Ferreira
Summary: Respiratory mucosal immunity induced by vaccination is vital for protection from coronavirus infection in animal models. However, peripheral vaccination alone does not appear to induce durable lung mucosal immunity against SARS-CoV-2. Donors with a history of both infection and vaccination have more airway mucosal SARS-CoV-2 antibodies and memory B cells than those only vaccinated. Infection also induces populations of airway spike-specific memory CD4+ and CD8+ T cells that are not expanded by vaccination alone.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Disha Bhavsar, Gagandeep Singh, Kaori Sano, Charles Gleason, Komal Srivastava, Juan Manuel Carreno, Viviana Simon, Florian Krammer
Summary: This study investigates the induction of serum IgG, saliva IgG, and saliva sIgA after COVID-19 mRNA booster vaccination or breakthrough infections. Antibodies on mucosal surfaces of the upper respiratory tract have been shown to be important for protection from infection with SARS-CoV-2.
Article
Multidisciplinary Sciences
Xingyue An, Melisa Martinez-Paniagua, Ali Rezvan, Samiur Rahman Sefat, Mohsen Fathi, Shailbala Singh, Sujit Biswas, Melissa Pourpak, Cassian Yee, Xinli Liu, Navin Varadarajan
Summary: The development of an intranasal subunit vaccine that induces mucosal immunity in the respiratory tract has been reported, demonstrating the potential to prevent infection establishment in individuals and disease transmission.
Article
Immunology
Sean A. Nelson, Andrea J. Sant
Summary: Administration of yearly influenza vaccines is the most effective way to control the spread of influenza virus, but practical and immunological factors can lead to sub-optimal vaccine efficacy. The development of improved or universal influenza vaccines has been a focus within the field, with attention on the route of immunization to elicit tissue resident memory populations. The unique features of mucosal immunity in the upper and lower respiratory tracts suggest the importance of antigen localization in intranasal vaccine design for eliciting protective B and T cell immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Joshua Heuler, Harish Chandra, Xingmin Sun
Summary: Clostridioides difficile infection (CDI) is a significant public health threat due to its ability to cause recurrent and life-threatening diarrhea and intestinal inflammation. The pathogen's antibiotic resistance and spore-forming capability make it challenging to eradicate from healthcare settings, emphasizing the importance of preventative measures. A mucosal vaccine that generates strong immune responses holds promise in preventing colonization and disease. This mini-review summarizes the progress and potential targets for mucosal vaccines against C. difficile, aiming to guide future research towards an effective vaccine against CDI.
Review
Immunology
Rosendo Luria-Perez, Luis A. Sanchez-Vargas, Paola Munoz-Lopez, Gabriela Mellado-Sanchez
Summary: The Flaviviridae family consists of RNA enveloped viruses that cause diseases in humans, with mucosal vaccines showing promise as an alternative route for immunization due to their ability to induce long-term immunity, needle-free administration, and diverse antigen delivery systems.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Behnaz Eshaghi, Alex Schudel, Ilin Sadeghi, Ziqi Chen, Amy H. Lee, Maria Kanelli, Flora Tierney, Jooli Han, Bailey Ingalls, David M. Francis, Gary Li, Ulrich von Andrian, Robert Langer, Ana Jaklenec
Summary: Mucosal vaccines play a critical role in combating mucosal pathogens by directly neutralizing the invading pathogens. This review examines the role of material design in addressing the challenges associated with mucosal vaccine delivery and discusses different classes of materials currently being used.
NATURE REVIEWS MATERIALS
(2023)
Review
Immunology
Estefania Munoz-Atienza, Patricia Diaz-Rosales, Carolina Tafalla
Summary: The development of mucosal vaccines against pathogens is a highly explored area of research, as they have the potential to best elicit protective responses at mucosal surfaces. In order to provide efficient long-lasting protection, mucosal vaccines must elicit adequate systemic immune responses in addition to local responses. The organization and response of B and T cells in teleost fish within mucosal sites vary greatly from mammals, highlighting the importance of identifying antigens that can induce strong and long-lasting immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Biomedical
Si Sun, Entao Li, Gan Zhao, Jie Tang, Qianfei Zuo, Larry Cai, Chuanfei Xu, Cheng Sui, Yangxue Ou, Chang Liu, Haibo Li, Yuan Ding, Chao Li, Dongshui Lu, Weijun Zhang, Ping Luo, Ping Cheng, Yuwei Gao, Changchun Tu, Bruno Pitard, Joseph Rosenecker, Bin Wang, Yan Liu, Quanming Zou, Shan Guan
Summary: This study used self-assembled peptide-poloxamine nanoparticles for pulmonary inoculation of a COVID-19 DNA vaccine, which showed superior gene transfection and biocompatibility in the mouse airway. The vaccine induced mucosal immune responses against SARS-CoV-2, resulting in complete elimination of the infection and 100% survival rate in mice.
Article
Immunology
Stephanie Longet, Alexander Hargreaves, Saoirse Healy, Rebecca Brown, Hailey R. Hornsby, Naomi Meardon, Tom Tipton, Eleanor Barnes, Susanna Dunachie, Christopher J. A. Duncan, Paul Klenerman, Alex Richter, Lance Turtle, Thushan I. de Silva, Miles W. Carroll
Summary: Two doses of BNT162b2 mRNA vaccine induce a strong systemic humoral response to SARS-CoV-2, but mucosal immune response is important for defense against airborne transmission. This study characterizes the IgG responses to SARS-CoV-2 and other coronaviruses in oral fluid and plasma samples from UK healthcare workers. It also investigates the impact of previous infection and additional vaccine doses on the immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Victor Vaernewyck, Boaz Arzi, Niek N. Sanders, Eric Cox, Bert Devriendt
Summary: Periodontal disease affects a large portion of adults and can lead to systemic disorders. Control options primarily focus on removing plaque and calculus, but altering host inflammatory response and reducing bacterial triggers are also important. Vaccines may provide a potent adjunct to mechanical debridement for prevention and treatment, but the complexity of periodontal disease complicates vaccine development. Recent advances in mucosal vaccination may help bridge this gap.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Tobias Eggert, Katharina Wolter, Juling Ji, Chi Ma, Tetyana Yevsa, Sabrina Klotz, Jose Medina-Echeverz, Thomas Longerich, Marshonna Forgues, Florian Reisinger, Mathias Heikenwalder, Xin Wei Wang, Lars Zender, Tim F. Greten
Article
Gastroenterology & Hepatology
Engin Guerlevik, Bettina Fleischmann-Mundt, Jennifer Brooks, Ihsan Ekin Demir, Katja Steiger, Silvia Ribback, Tetyana Yevsa, Norman Woller, Arnold Kloos, Dmitrij Ostroumov, Nina Armbrecht, Michael P. Manns, Frank Dombrowski, Michael Saborowski, Moritz Kleine, Thomas C. Wirth, Helmut Oettle, Gueralp O. Ceyhan, Irene Esposito, Diego F. Calvisi, Stefan Kubicka, Florian Kuehnel
Article
Biochemistry & Molecular Biology
Daniel Dauch, Ramona Rudalska, Giacomo Cossa, Jean-Charles Nault, Tae-Won Kang, Torsten Wuestefeld, Anja Hohmeyer, Sandrine Imbeaud, Tetyana Yevsa, Lisa Hoenicke, Tatu Pantsar, Przemyslaw Bozko, Nisar P. Malek, Thomas Longerich, Stefan Laufer, Antti Poso, Jessica Zucman-Rossi, Martin Eilers, Lars Zender
Article
Immunology
B. C. Rabinovitz, M. Larzabal, D. A. Vilte, A. Cataldi, E. C. Mercado
Article
Rheumatology
Annika Reinhardt, Tetyana Yevsa, Tim Worbs, Stefan Lienenklaus, Inga Sandrock, Linda Oberdoerfer, Thomas Korn, Siegfried Weiss, Reinhold Foerster, Immo Prinz
ARTHRITIS & RHEUMATOLOGY
(2016)
Article
Veterinary Sciences
Ana M. Canal, Natalia Pezzone, Angel Cataldi, Martin Zumarraga, Mariano Larzabal, Sergio Garbaccio, Analia Fernandez, Lucas Dominguez, Alicia Aranaz, Antonio Rodriguez-Bertos
RESEARCH IN VETERINARY SCIENCE
(2017)
Article
Biotechnology & Applied Microbiology
Inga Hochnadel, Uta Kossatz-Boehlert, Nils Jedicke, Henrike Lenzen, Michael P. Manns, Tetyana Yevsa
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2017)
Article
Immunology
Beata M. Zygmunt, Agnieszka Wegrzyn, Weronika Gajska, Tetyana Yevsa, Grzegorz Chodaczek, Carlos A. Guzman
JOURNAL OF IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Andreas Jeron, Julia D. Boehme, Julia Volckmar, Marcus Gereke, Tetyana Yevsa, Robert Geffers, Carlos A. Guzman, Jens Schreiber, Sabine Stegemann-Koniszewski, Dunja Bruder
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Multidisciplinary Sciences
Natalia Amigo, Qi Zhang, Ariel Amadio, Qunjie Zhang, Wanderson M. Silva, Baiyuan Cui, Zhongjian Chen, Mariano Larzabal, Jinlong Bei, Angel Cataldi
Article
Multidisciplinary Sciences
Wanderson Marques Da Silva, Jinlong Bei, Natalia Amigo, Maria Pia Valacco, Ariel Amadio, Qi Zhang, Xiuju Wu, Ting Yu, Mariano Larzabal, Zhuang Chen, Angel Cataldi
Article
Biochemistry & Molecular Biology
Mariano Larzabal, Hector A. Baldoni, Fernando D. Suvire, Lucrecia M. Curto, Gabriela E. Gomez, Wanderson Marques Da Silva, Silvana L. Giudicessi, Silvia A. Camperi, Jose M. Delfino, Angel A. Cataldi, Daniel Enriz
JOURNAL OF PEPTIDE SCIENCE
(2019)
Article
Cardiac & Cardiovascular Systems
J. Stolk, N. Aggarwal, I. Hochnadel, S. Wrenger, B. Martinez-Delgado, T. Welte, T. Yevsa, S. Janciauskiene
RESPIRATORY MEDICINE
(2019)
Review
Microbiology
Fernando Navarro-Garcia, Fernando Ruiz-Perez, Angel Cataldi, Mariano Larzabal
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Microbiology
Mariano Larzabal, Wanderson Marques Da Silva, Nahuel A. Riviere, Angel A. Cataldi
