Review
Immunology
Laura Santambrogio
Summary: Advances in the analysis of the MHC class II ligandome have increased our understanding of the factors that regulate the range and selection of presented peptides, and the landscape is highly sensitive to changes in protein composition.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Yanyi Chu, Yan Zhang, Qiankun Wang, Lingfeng Zhang, Xuhong Wang, Yanjing Wang, Dennis Russell Salahub, Qin Xu, Jianmin Wang, Xue Jiang, Yi Xiong, Dong-Qing Wei
Summary: The study presents the TransMut framework, which automatically optimizes mutated peptides with higher affinity to the target HLA allele. This framework provides an automated approach for screening immunogenic peptides and vaccine design.
NATURE MACHINE INTELLIGENCE
(2022)
Article
Biochemical Research Methods
Raphael Trevizani, Zhen Yan, Jason A. Greenbaum, Alessandro Sette, Morten Nielsen, Bjoern Peters
Summary: An approach to assess the reliability of different metrics for evaluating the performance of MHC class I binding predictors was developed. The study found that using percentile-ranked results improved the stability of the ranks and identified the top-performing tools in the benchmark.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Immunology
Fabrizio Celesti, Andrea Gatta, Mariam Shallak, Anna Maria Chiaravalli, Michele Cerati, Fausto Sessa, Roberto S. Accolla, Greta Forlani
Summary: In an animal experimental system, vaccination with glioblastoma GL261 cells expressing CIITA showed successful protection against glioblastoma growth. The activation of MHC class II through CIITA led to rapid infiltration of CD4+ and CD8+ T cells, resulting in the rejection or retardation of tumor growth. This approach demonstrates the potential application of novel immunotherapeutic strategies in the clinical setting.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Giacomo Oliveira, Kari Stromhaug, Nicoletta Cieri, J. Bryan Iorgulescu, Susan Klaeger, Jacquelyn O. Wolff, Suzanna Rachimi, Vipheaviny Chea, Kate Krause, Samuel S. Freeman, Wandi Zhang, Shuqiang Li, David A. Braun, Donna Neuberg, Steven A. Carr, Kenneth J. Livak, Dennie T. Frederick, Edward F. Fritsch, Megan Wind-Rotolo, Nir Hacohen, Moshe Sade-Feldman, Charles H. Yoon, Derin B. Keskin, Patrick A. Ott, Scott J. Rodig, Genevieve M. Boland, Catherine J. Wu
Summary: In this study, the phenotype and tumor specificity of CD4 (+) T cells infiltrating human melanoma specimens were analyzed in depth, revealing that melanoma cells can directly induce exhausted cytotoxic CD4 (+) T cells through recognition of HLA class II-restricted neoantigens and HLA class I-restricted tumor-associated antigens. CD4 (+) T regulatory (T-Reg) cells can be indirectly elicited through the presentation of tumor antigens via antigen-presenting cells. Interestingly, a large number of tumor-reactive CD4 (+) T-Reg clones were stimulated directly by HLA class II-positive melanoma and showed specificity for melanoma neoantigens. These findings suggest that the presentation of HLA class II-restricted neoantigens and direct engagement of immunosuppressive CD4 (+) T-Reg cells are favored mechanisms of immune evasion in HLA class II-positive melanoma.
Article
Multidisciplinary Sciences
Junki Hirano, Sachiyo Yoshio, Yusuke Sakai, Li Songling, Tatsuya Suzuki, Yumi Itoh, He Zhang, David Virya Chen, Saori Haga, Hiroko Oomori, Takahiro Kodama, Yusuke Maeda, Yoshihiro Ono, Yu Takahashi, Daron M. Standley, Masahiro Yamamoto, Kohji Moriishi, Kyoji Moriya, Tatsuya Kanto, Tetsuo Takehara, Kazuhiko Koike, Yoshiharu Matsuura, Toru Okamoto
Summary: Immunoevasins such as the HCV core protein interfere with the maturation and expression of MHC class I molecules, impairing antigen presentation to CD8(+) T cells and evading immune recognition. Targeting the signal peptide peptidase (SPP) may represent a potential strategy to impair MHC class I molecules by both DNA and RNA viruses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Tamara Hofer, Matteo Rossi, Susanna Carboni, Wilma Di Berardino Besson, Dorothee von Laer, Guido Wollmann, Madiha Derouazi, Marie-Laure Santiago-Raber
Summary: Developing new therapeutic cancer vaccines is crucial to combat tumor escape after conventional therapies in certain types of cancer. The study's multi-epitope vaccine can induce potent anti-tumor immune responses in various tumor models, laying a foundation for cancer immunotherapy.
Article
Multidisciplinary Sciences
Haiyin Liu, Kayla R. Wilson, Ashley M. Firth, Christophe Macri, Patrick Schriek, Annabelle B. Blum, Javiera Villar, Samuel Wormald, Mitch Shambrook, Bangyan Xu, Hui Jing Lim, Hamish E. G. McWilliam, Andrew F. Hill, Laura E. Edgington-Mitchell, Irina Caminschi, Mireille H. Lahoud, Elodie Segura, Marco J. Herold, Jose A. Villadangos, Justine D. Mintern
Summary: This study reveals the critical role of ubiquitin-like protein 3 (UBL3) in the trafficking process controlled by MARCH1. UBL3 has wide-ranging immunological consequences and is essential for immune responses.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Amanda M. Honan, Emily N. Vazquez, Zhibin Chen
Summary: The study revealed that CD8(+) T cells can convert to CD4(+) T cells in mice, resulting in a unique population of MHC-I-restricted CD4(+) T cells. This conversion process is influenced by MHC-II expression in lymph node stromal cells and involves a specific transcriptional switch. In vitro expansion of CI-T-reg cells using LNSCs showed potential for therapeutic applications in suppressing inflammatory tissue damage.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Rong En Tay, Emma K. Richardson, Han Chong Toh
Summary: Cancer immunotherapy has transformed cancer treatment, with immune checkpoint blockade therapy and adoptive cell therapy becoming standard care for many cancer types. Recent evidence suggests that CD4(+)T cells play a significant role in the anti-tumour immune response, highlighting their potential importance in cancer immunotherapies.
CANCER GENE THERAPY
(2021)
Article
Multidisciplinary Sciences
Jeff D. Colbert, Freidrich M. Cruz, Christina E. Baer, Kenneth L. Rock
Summary: This study reveals a molecular association between Tspan5 and MHC I molecules that is critical for the formation of MHC I nanoclusters and optimal T cell responses to antigens.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Lei Zhan, Junhui Zhang, Jing Zhang, Xiaojing Liu, Suding Zhu, Yuchuan Shi, Yu He, Wenyan Wang, Yijing Wei, Zhenhai Tang, Guo Chen, Bing Wei, Yunxia Cao
Summary: In this study, the researchers found that upregulated autophagy and decreased expression of MHC-I and NLRC5 were associated with endometrial cancer (EC). Inhibition of autophagy was found to suppress MHC-I gene expression. They also discovered that LC3 interacted with NLRC5 to inhibit the NLRC5-mediated MHC-I antigen presentation pathway. These findings suggest that inhibiting LC3 and promoting NLRC5 may be a promising immunotherapy strategy for EC management.
Article
Multidisciplinary Sciences
Ewa Maria Sroka, Mathilde Lavigne, Marika Pla, Chrysoula Daskalogianni, Maria Camila Tovar-Fernandez, Rodrigo Prado Martins, Benedicte Manoury, Guillaume Darrasse-Jeze, Megane Nascimento, Sebastien Apcher, Robin Fahraeus
Summary: This study found that introducing an MHC class I epitope sequence into the intron of the beta-globin gene in mice can generate immune tolerance. Translation initiation within the intron produces peptides for MHC class I immune tolerance, providing an explanation for the tolerance of alternative tissue-specific splicing by the immune system.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Medicine, General & Internal
Jing Liu, Xuefeng Chen, Ju Wang, Fang Wu, Jie Zhang, Jiangtao Dong, Hui Zhang, Xiaoling Liu, Na Hu, Jiangdong Wu, Le Zhang, Wei Cheng, Chunjun Zhang, Wan Jiang Zhang
Summary: The study predicted and identified 5 novel candidate CD4+T cell epitope polypeptides, with P-39, P-62, and P-39+P-62 showing effective induction of CD4+T cell proliferation and increased secretion of cytokines, providing potential candidate epitope polypeptides for the development of TB-specific diagnosis reagents and novel TB epitope vaccines.
Article
Multidisciplinary Sciences
Brett A. Eyford, Maciej J. Lazarczyk, Kyung Bok Choi, Merina Varghese, Hitesh Arora, Suresh Kari, Lonna Munro, Cheryl G. Pfeifer, Allison Sowa, Daniel R. Dickstein, Dara L. Dickstein, Wilfred A. Jefferies
Summary: This study investigates the significance of the cytoplasmic tail of MHC-I in synaptic signaling and its impact on the expression of synaptic glutamate receptors. The findings reveal that the Y321F substitution influences the expression of AMPAR subunits and alters the phosphorylation of key kinases. These results illuminate the crucial role of MHC-I in AMPAR function and synaptic plasticity modulation.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Lavakumar Karyampudi, Purushottam Lamichhane, James Krempski, Kimberly R. Kalli, Marshall D. Behrens, Doris M. Vargas, Lynn C. Hartmann, Jo Marie T. Janco, Haidong Dong, Karen E. Hedin, Allan B. Dietz, Ellen L. Goode, Keith L. Knutson
Article
Biochemistry & Molecular Biology
Kimberly N. Kremer, Amel Dudakovic, Allan D. Hess, B. Douglas Smith, Judith E. Karp, Scott H. Kaufmann, Jennifer J. Westendorf, Andre J. van Wijnen, Karen E. Hedin
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Cell Biology
Adebowale O. Bamidele, Kimberly N. Kremer, Petra Hirsova, Ian C. Clift, Gregory J. Gores, Daniel D. Billadeau, Karen E. Hedin
JOURNAL OF CELL BIOLOGY
(2015)
Article
Oncology
Rosalie M. Sterner, Kimberly N. Kremer, Aref Al-Kali, Mrinal M. Patnaik, Naseema Gangat, Mark R. Litzow, Scott H. Kaufmann, Jennifer J. Westendorf, Andre J. van Wijnen, Karen E. Hedin
Article
Biochemistry & Molecular Biology
Brittney A. Dinkel, Kimberly N. Kremer, Meagan R. Rollins, Michael J. Medlyn, Karen E. Hedin
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Immunology
Rosalie M. Sterner, Kimberly N. Kremer, Amel Dudakovic, Jennifer J. Westendorf, Andre J. van Wijnen, Karen E. Hedin
JOURNAL OF IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Kimberly N. Kremer, Kevin L. Peterson, Paula A. Schneider, X. Wei Meng, Haiming Dai, Allan D. Hess, B. Douglas Smith, Christie Rodriguez-Ramirez, Judith E. Karp, Scott H. Kaufmann, Karen E. Hedin
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Kimberly N. Kremer, Amel Dudakovic, Meghan E. McGee-Lawrence, Rachael L. Philips, Allan D. Hess, B. Douglas Smith, Andre J. van Wijnen, Judith E. Karp, Scott H. Kaufmann, Jennifer J. Westendorf, Karen E. Hedin
JOURNAL OF CELLULAR BIOCHEMISTRY
(2014)
Article
Immunology
Ashok Kumar, Kimberly N. Kremer, Daniel Dominguez, Madhavi Tadi, Karen E. Hedin
JOURNAL OF IMMUNOLOGY
(2011)
Article
Immunology
Kimberly N. Kremer, Ashok Kumar, Karen E. Hedin
JOURNAL OF IMMUNOLOGY
(2011)
Article
Immunology
Kimberly N. Kremer, Ian C. Clift, Alexander G. Miamen, Adebowale O. Bamidele, Nan-Xin Qian, Troy D. Humphreys, Karen E. Hedin
JOURNAL OF IMMUNOLOGY
(2011)
Article
Multidisciplinary Sciences
Joanna Kim, Michael J. Shapiro, Adebowale O. Bamidele, Pinar Gurel, Puspa Thapa, Henry N. Higgs, Karen E. Hedin, Virginia S. Shapiro, Daniel D. Billadeau
Article
Hematology
Rosalie M. Sterner, Reona Sakemura, Michelle J. Cox, Nan Yang, Roman H. Khadka, Cynthia L. Forsman, Michael J. Hansen, Fang Jin, Katayoun Ayasoufi, Mehrdad Hefazi, Kendall J. Schick, Denise K. Walters, Omar Ahmed, Dale Chappell, Tarek Sahmoud, Cameron Durrant, Wendy K. Nevala, Mrinal M. Patnaik, Larry R. Pease, Karen E. Hedin, Neil E. Kay, Aaron J. Johnson, Saad S. Kenderian
Article
Hematology
Kimberly N. Kremer, Brittney A. Dinkel, Rosalie M. Sterner, Douglas G. Osborne, Dragan Jevremovic, Karen E. Hedin
Article
Pharmacology & Pharmacy
Ian C. Clift, Adebowale O. Bamidele, Christie Rodriguez-Ramirez, Kimberly N. Kremer, Karen E. Hedin
MOLECULAR PHARMACOLOGY
(2014)