Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress

Importin β-dependent nuclear import of TopBP1 in ATR–Chk1 checkpoint in Xenopus egg extracts

(2014) Liping Bai et al.   CELLULAR SIGNALLING

Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Definedin VitroSystem

(2014) Laura A. Lindsey-Boltz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative DNA damage is involved in ochratoxin A-induced G2 arrest through ataxia telangiectasia-mutated (ATM) pathways in human gastric epithelium GES-1 cells in vitro

(2013) Jinfeng Cui et al.   ARCHIVES OF TOXICOLOGY

WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling

(2013) Shan Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of TDP1 and APTX in mitochondrial DNA repair

(2013) Martin Meagher et al.   BIOCHIMIE

Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions

(2013) M. Ambrose et al.   BLOOD

Checkpoint kinase 1 in DNA damage response and cell cycle regulation

(2013) Mallikarjun Patil et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks

(2013) Elisa Gobbini et al.   DNA REPAIR

NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites

(2013) Alo Ray et al.   DNA REPAIR

Mismatch repair deficiency in ovarian cancer — Molecular characteristics and clinical implications

(2013) Xue Xiao et al.   GYNECOLOGIC ONCOLOGY

Roles of Chk1 in cell biology and cancer therapy

(2013) Youwei Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Oxidative Stress as an Underlying Contributor in the Development of Chronic Complications in Diabetes Mellitus

(2013) Suziy de M. Bandeira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pathogenesis of Chronic Cardiorenal Syndrome: Is There a Role for Oxidative Stress?

(2013) Speranza Rubattu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

4-Hydroxynonenal Induces G2/M Phase Cell Cycle Arrest by Activation of the Ataxia Telangiectasia Mutated and Rad3-related Protein (ATR)/Checkpoint Kinase 1 (Chk1) Signaling Pathway

(2013) Pankaj Chaudhary et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks

(2013) Joon Lee et al.   MOLECULAR BIOLOGY OF THE CELL

A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment

(2013) Anja M. Duursma et al.   MOLECULAR CELL

Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage

(2013) Yang Yang et al.   NUCLEIC ACIDS RESEARCH

Oxidative Stress-Induced DNA Damage and Repair in Human Peripheral Blood Mononuclear Cells: Protective Role of Hemoglobin

(2013) Anat Gafter-Gvili et al.   PLoS One

APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress

(2013) J. Willis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Damage Response: Three Levels of DNA Repair Regulation

(2013) B. M. Sirbu et al.   Cold Spring Harbor Perspectives in Biology

Postreplicative Mismatch Repair

(2013) J. Jiricny   Cold Spring Harbor Perspectives in Biology

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

Oxidative Stress and Replication-Independent DNA Breakage Induced by Arsenic in Saccharomyces cerevisiae

(2013) Ireneusz Litwin et al.   PLoS Genetics

Oxidative Stress and the DNA Mismatch Repair Pathway

(2012) David J. Brierley et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative DNA Damage and Nucleotide Excision Repair

(2012) Joost P.M. Melis et al.   ANTIOXIDANTS & REDOX SIGNALING

Base excision repair and cancer

(2012) Susan S. Wallace et al.   CANCER LETTERS

Oxidatively induced DNA damage: Mechanisms, repair and disease

(2012) Miral Dizdaroglu   CANCER LETTERS

Pathways for repairing and tolerating the spectrum of oxidative DNA lesions

(2012) Brian R. Berquist et al.   CANCER LETTERS

Oxidatively generated complex DNA damage: Tandem and clustered lesions

(2012) Jean Cadet et al.   CANCER LETTERS

Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells

(2012) Alan G. Raetz et al.   CARCINOGENESIS

Endonuclease V: an unusual enzyme for repair of DNA deamination

(2012) Weiguo Cao   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms of replication fork protection: a safeguard for genome stability

(2012) Alessia Errico et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1) is an indicator of energy disruption in neurons

(2012) Shilpee Singh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids

(2012) Jean Cadet et al.   FREE RADICAL RESEARCH

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

(2012) Y. Yin et al.   GENES & DEVELOPMENT

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

(2012) Y. Galanty et al.   GENES & DEVELOPMENT

Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases

(2012) Muralidhar L. Hegde et al.   MECHANISMS OF AGEING AND DEVELOPMENT

DNA damage by singlet oxygen and cellular protective mechanisms

(2012) Lucymara F. Agnez-Lima et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Pathological neoangiogenesis depends on oxidative stress regulation by ATM

(2012) Yuji Okuno et al.   NATURE MEDICINE

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

ATR signalling: more than meeting at the fork

(2011) Edward A. Nam et al.   BIOCHEMICAL JOURNAL

New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress

(2011) Benjamin P.C. Chen et al.   CANCER LETTERS

Unrepaired oxidative DNA damage induces an ATR/ATM apoptotic-like response in quiescent fission yeast

(2011) Benoit Arcangioli et al.   CELL CYCLE

ATR kinase as master regulator of nucleotide excision repair during S phase of the cell cycle

(2011) Yannick Auclair et al.   CELL CYCLE

ATM protein kinase: the linchpin of cellular defenses to stress

(2011) Shahzad Bhatti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Eukaryotic DNA damage checkpoint activation in response to double-strand breaks

(2011) Karen Finn et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Lycopene inhibits Helicobacter pylori -induced ATM/ATR-dependent DNA damage response in gastric epithelial AGS cells

(2011) Sung Hee Jang et al.   FREE RADICAL BIOLOGY AND MEDICINE

BRCA1 is required for hMLH1 stabilization following doxorubicin-induced DNA damage

(2011) Francesco Romeo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

hMSH2 Recruits ATR to DNA Damage Sites for Activation during DNA Damage-induced Apoptosis

(2011) Navjotsingh Pabla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MDC1 collaborates with TopBP1 in DNA replication checkpoint control

(2011) Jiadong Wang et al.   JOURNAL OF CELL BIOLOGY

Artesunate Induces Oxidative DNA Damage, Sustained DNA Double-Strand Breaks, and the ATM/ATR Damage Response in Cancer Cells

(2011) N. Berdelle et al.   MOLECULAR CANCER THERAPEUTICS

Measurement of oxidatively generated base damage in cellular DNA

(2011) Jean Cadet et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation

(2011) S. Sertic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress

(2011) M. Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Base Excision Repair and Lesion-Dependent Subpathways for Repair of Oxidative DNA Damage

(2010) David Svilar et al.   ANTIOXIDANTS & REDOX SIGNALING

SnapShot: Nucleotide Excision Repair

(2010) Caixia Guo et al.   CELL

UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells

(2010) Kyu-Seon Oh et al.   DNA REPAIR

Selenium Compounds Activate ATM-dependent DNA Damage Response via the Mismatch Repair Protein hMLH1 in Colorectal Cancer Cells

(2010) Yongmei Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ATM Cofactor ATMIN Protects against Oxidative Stress and Accumulation of DNA Damage in the Aging Brain

(2010) Nnennaya Kanu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exo1 Competes with Repair Synthesis, Converts NER Intermediates to Long ssDNA Gaps, and Promotes Checkpoint Activation

(2010) Michele Giannattasio et al.   MOLECULAR CELL

BACH1/FANCJ Acts with TopBP1 and Participates Early in DNA Replication Checkpoint Control

(2010) Zihua Gong et al.   MOLECULAR CELL

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Maintaining genome stability at the replication fork

(2010) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin

(2009) Michela Di Virgilio et al.   DNA REPAIR

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

(2009) Benu Brata Das et al.   EMBO JOURNAL

Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway

(2009) Yiyong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks

(2009) Shan Yan et al.   JOURNAL OF CELL BIOLOGY

Crystal Structure of the Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex—Implications for Clamp Loading and Regulation

(2009) Andrew S. Doré et al.   MOLECULAR CELL

CtIP Links DNA Double-Strand Break Sensing to Resection

(2009) Zhongsheng You et al.   MOLECULAR CELL

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

(2009) Bunsyo Shiotani et al.   MOLECULAR CELL

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

(2009) Yaron Galanty et al.   NATURE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation

(2008) Amit Kulkarni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

The methyl methanesulfonate induced S-phase delay in XRCC1-deficient cells requires ATM and ATR

(2008) Reto Brem et al.   DNA REPAIR

Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair

(2008) Wen-Cheng Chou et al.   EMBO JOURNAL

Chk1 and Claspin potentiate PCNA ubiquitination

(2008) X. H. Yang et al.   GENES & DEVELOPMENT

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

(2008) D. A. Mordes et al.   GENES & DEVELOPMENT

The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine

(2008) Angen Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

DNA Double-Strand Break Formation upon UV-Induced Replication Stress Activates ATM and DNA-PKcs Kinases

(2008) Hirohiko Yajima et al.   JOURNAL OF MOLECULAR BIOLOGY

Use of Comet-FISH in the study of DNA damage and repair: Review

(2008) M GLEI et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

(2008) Martin F. Lavin   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATR kinase is required for global genomic nucleotide excision repair exclusively during S phase in human cells

(2008) Y. Auclair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions

(2008) E. Soutoglou et al.   SCIENCE