Checkpoint kinase 1 in DNA damage response and cell cycle regulation

Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition

(2012) Amy D Guertin et al.   Cancer Cell International

DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism

(2012) Naoyuki Okita et al.   FEBS LETTERS

ATR signalling: more than meeting at the fork

(2011) Edward A. Nam et al.   BIOCHEMICAL JOURNAL

Unleashing Chk1 in cancer therapy

(2011) Laura Carrassa et al.   CELL CYCLE

hMSH2 Recruits ATR to DNA Damage Sites for Activation during DNA Damage-induced Apoptosis

(2011) Navjotsingh Pabla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication

(2011) C. S. Sorensen et al.   NUCLEIC ACIDS RESEARCH

Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis

(2011) L M Tho et al.   ONCOGENE

Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints

(2011) N. Pabla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1

(2011) Melanie Blasius et al.   GENOME BIOLOGY

New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network

(2010) Y. Dai et al.   CLINICAL CANCER RESEARCH

14-3-3γ mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage

(2010) Kousuke Kasahara et al.   EMBO JOURNAL

Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange

(2010) Bret D Freudenthal et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents

(2010) S Zenvirt et al.   ONCOGENE

Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53

(2010) T Fishler et al.   ONCOGENE

Chk1 promotes replication fork progression by controlling replication initiation

(2010) E. Petermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress

(2009) You-Wei Zhang et al.   MOLECULAR CELL

NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint

(2009) Marina Melixetian et al.   NATURE CELL BIOLOGY

Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity

(2009) M Walker et al.   ONCOGENE

The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis

(2009) S. Peddibhotla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Chk1

(2009) Claudia Tapia-Alveal et al.   Cell Division

ATR and Chk1 Suppress a Caspase-3–Dependent Apoptotic Response Following DNA Replication Stress

(2009) Katie Myers et al.   PLoS Genetics

Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3

(2008) Samuel Sidi et al.   CELL

Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression

(2008) Midori Shimada et al.   CELL

DNA Damage Repair and Response Proteins as Targets for Cancer Therapy

(2008) Howard Lieberman   CURRENT MEDICINAL CHEMISTRY

Chk1 and Claspin potentiate PCNA ubiquitination

(2008) X. H. Yang et al.   GENES & DEVELOPMENT

Expanded Roles for Chk1 in Genome Maintenance

(2008) Greg H. Enders   JOURNAL OF BIOLOGICAL CHEMISTRY

Grapes(Chk1) prevents nuclear CDK1 activation by delaying cyclin B nuclear accumulation

(2008) Anne Royou et al.   JOURNAL OF CELL BIOLOGY

U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint

(2008) Laura Carrassa et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Regulation of Chk1 by Its C-terminal Domain

(2008) Ana Kosoy et al.   MOLECULAR BIOLOGY OF THE CELL

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY