标题
Roles of Chk1 in cell biology and cancer therapy
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF CANCER
Volume 134, Issue 5, Pages 1013-1023
出版商
Wiley
发表日期
2013-04-24
DOI
10.1002/ijc.28226
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Interferon-gamma enhances radiation-induced cell death via downregulation of Chk1
- (2012) Kwang Seok Kim et al. CANCER BIOLOGY & THERAPY
- Autoregulatory Mechanisms of Phosphorylation of Checkpoint Kinase 1
- (2012) J. Wang et al. CANCER RESEARCH
- Checkpoint kinase 1 inhibitors for potentiating systemic anticancer therapy
- (2012) M. Maugeri-Saccà et al. CANCER TREATMENT REVIEWS
- A DNA-Damage Selective Role for BRCA1 E3 Ligase in Claspin Ubiquitylation, CHK1 Activation, and DNA Repair
- (2012) Ko Sato et al. CURRENT BIOLOGY
- Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response
- (2012) Chen Hu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Coupling Cellular Localization and Function of Checkpoint Kinase 1 (Chk1) in Checkpoints and Cell Viability
- (2012) Jingna Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma
- (2012) Jian Hong et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models
- (2012) Cynthia X. Ma et al. JOURNAL OF CLINICAL INVESTIGATION
- An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation
- (2012) Andres J. López-Contreras et al. JOURNAL OF EXPERIMENTAL MEDICINE
- CRL4CDT2 Targets CHK1 for PCNA-Independent Destruction
- (2012) J. Huh et al. MOLECULAR AND CELLULAR BIOLOGY
- P90 RSK arranges Chk1 in the nucleus for monitoring of genomic integrity during cell proliferation
- (2012) Ping Li et al. MOLECULAR BIOLOGY OF THE CELL
- Suppressed miR-424 expression via upregulation of target gene Chk1 contributes to the progression of cervical cancer
- (2012) J Xu et al. ONCOGENE
- Chk1 phosphorylation of Metnase enhances DNA repair but inhibits replication fork restart
- (2012) R Hromas et al. ONCOGENE
- Molecular Resistance Fingerprint of Pemetrexed and Platinum in a Long-Term Survivor of Mesothelioma
- (2012) Oluf Dimitri Røe et al. PLoS One
- Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress
- (2011) Yukihiro Furusawa et al. APOPTOSIS
- Glucose deprivation is associated with Chk1 degradation through the ubiquitin–proteasome pathway and effective checkpoint response to replication blocks
- (2011) Ae Jeong Kim et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Replication stress activates DNA polymerase alpha-associated Chk1
- (2011) Lorena Taricani et al. CELL CYCLE
- Unleashing Chk1 in cancer therapy
- (2011) Laura Carrassa et al. CELL CYCLE
- Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy
- (2011) M Bartucci et al. CELL DEATH AND DIFFERENTIATION
- USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation
- (2011) Jean-Hugues Guervilly et al. HUMAN MOLECULAR GENETICS
- Phosphorylation at serine 331 is required for Aurora B activation
- (2011) Eleni Petsalaki et al. JOURNAL OF CELL BIOLOGY
- Nuclear Chk1 prevents premature mitotic entry
- (2011) M. Matsuyama et al. JOURNAL OF CELL SCIENCE
- Checkpoint Kinase 1 Prevents Cell Cycle Exit Linked to Terminal Cell Differentiation
- (2011) Z. Ullah et al. MOLECULAR AND CELLULAR BIOLOGY
- Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1
- (2011) Zheng Meng et al. MOLECULAR BIOLOGY OF THE CELL
- p50 (NF-κB1) Is an Effector Protein in the Cytotoxic Response to DNA Methylation Damage
- (2011) Adam M. Schmitt et al. MOLECULAR CELL
- Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis
- (2011) L M Tho et al. ONCOGENE
- The Expression of DNA Damage Checkpoint Proteins and Prognostic Implication in Metastatic Brain Tumors
- (2011) Ho Jun Seol et al. ONCOLOGY RESEARCH
- Structure-Specific DNA Endonuclease Mus81/Eme1 Generates DNA Damage Caused by Chk1 Inactivation
- (2011) Josep V. Forment et al. PLoS One
- Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints
- (2011) N. Pabla et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase
- (2011) M. Kawasumi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of checkpoint kinase 1 (Chk1) in the mechanisms of resistance to histone deacetylase inhibitors
- (2011) J.-H. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma
- (2011) K. A. Cole et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1
- (2011) Melanie Blasius et al. GENOME BIOLOGY
- Targeting the checkpoint kinase Chk1 in cancer therapy
- (2010) Callie Merry et al. CELL CYCLE
- New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network
- (2010) Y. Dai et al. CLINICAL CANCER RESEARCH
- 14-3-3γ mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage
- (2010) Kousuke Kasahara et al. EMBO JOURNAL
- Screening for large genomic rearrangements of the BRIP1 and CHK1 genes in Finnish breast cancer families
- (2010) Szilvia Solyom et al. Familial Cancer
- RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells
- (2010) Shilpi Arora et al. GYNECOLOGIC ONCOLOGY
- Requirement of MTA1 in ATR-mediated DNA Damage Checkpoint Function
- (2010) Da-Qiang Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2
- (2010) Naihan Xu et al. JOURNAL OF CELL BIOLOGY
- Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response
- (2010) E. Malzer et al. JOURNAL OF CELL SCIENCE
- Chk1-Dependent Constitutive Phosphorylation of BLM Helicase at Serine 646 Decreases after DNA Damage
- (2010) S. Kaur et al. MOLECULAR CANCER RESEARCH
- Genetic instability and mammary tumor formation in mice carrying mammary-specific disruption of Chk1 and p53
- (2010) T Fishler et al. ONCOGENE
- Chk1 Haploinsufficiency Results in Anemia and Defective Erythropoiesis
- (2010) Nathan C. Boles et al. PLoS One
- Histone Deacetylase Inhibitors Downregulate Checkpoint Kinase 1 Expression to Induce Cell Death in Non-Small Cell Lung Cancer Cells
- (2010) William Brazelle et al. PLoS One
- Chk1 promotes replication fork progression by controlling replication initiation
- (2010) E. Petermann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics
- (2010) Cynthia X. Ma et al. TRENDS IN MOLECULAR MEDICINE
- Constitutive Activation of the DNA Damage Signaling Pathway in Acute Myeloid Leukemia with Complex Karyotype: Potential Importance for Checkpoint Targeting Therapy
- (2009) C. Cavelier et al. CANCER RESEARCH
- DDB1 Targets Chk1 to the Cul4 E3 Ligase Complex in Normal Cycling Cells and in Cells Experiencing Replication Stress
- (2009) V. Leung-Pineda et al. CANCER RESEARCH
- Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction
- (2009) G. Zhi et al. CANCER RESEARCH
- Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
- (2009) Travis H. Stracker et al. DNA REPAIR
- FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling
- (2009) Sarah Luke-Glaser et al. EMBO JOURNAL
- Novel Positive Feedback Loop between Cdk1 and Chk1 in the Nucleus during G2/M Transition
- (2009) Masato Enomoto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
- (2009) Yiyong Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Interaction with Checkpoint Kinase 1 Modulates the Recruitment of Nucleophosmin to Chromatin
- (2009) Songbi Chen et al. JOURNAL OF PROTEOME RESEARCH
- Checkpoint Signaling from a Single DNA Interstrand Crosslink
- (2009) Merav Ben-Yehoyada et al. MOLECULAR CELL
- The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress
- (2009) You-Wei Zhang et al. MOLECULAR CELL
- NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
- (2009) Marina Melixetian et al. NATURE CELL BIOLOGY
- Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stress
- (2009) T-P Sun et al. ONCOGENE
- Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity
- (2009) M Walker et al. ONCOGENE
- Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation
- (2009) K R Greenow et al. ONCOGENE
- The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis
- (2009) S. Peddibhotla et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cyclin A-Cdk1 regulates the origin firing program in mammalian cells
- (2009) Y. Katsuno et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression
- (2008) Midori Shimada et al. CELL
- Cleavage-mediated Activation of Chk1 during Apoptosis
- (2008) Kenkyo Matsuura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Conserved Proliferating Cell Nuclear Antigen-interacting Protein Sequence in Chk1 Is Required for Checkpoint Function
- (2008) Jennifer Scorah et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Chk1 by Its C-terminal Domain
- (2008) Ana Kosoy et al. MOLECULAR BIOLOGY OF THE CELL
- ATR: an essential regulator of genome integrity
- (2008) Karlene A. Cimprich et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Importance of a C-Terminal Conserved Region of Chk1 for Checkpoint Function
- (2008) Carmela Palermo et al. PLoS One
- Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control
- (2008) D. Wilsker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now