Orexin/hypocretin receptor signalling: a functional perspective

Physiology of the orexinergic/hypocretinergic system: a revisit in 2012

(2012) Jyrki P. Kukkonen   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Effects of orexin A on proliferation, survival, apoptosis and differentiation of 3T3-L1 preadipocytes into mature adipocytes

(2012) M. Skrzypski et al.   FEBS LETTERS

Orexinergic modulation of GABAergic neurotransmission to cardiac vagal neurons in the brain stem nucleus ambiguus changes during development

(2012) O. Dergacheva et al.   NEUROSCIENCE

Orexin-A excites pyramidal neurons in layer 2/3 of the rat prefrontal cortex

(2012) Jie Yan et al.   NEUROSCIENCE LETTERS

Control of Sleep and Wakefulness

(2012) Ritchie E. Brown et al.   PHYSIOLOGICAL REVIEWS

Orexin-A induces anxiety-like behavior through interactions with glutamatergic receptors in the bed nucleus of the stria terminalis of rats

(2012) Elizabeth A. Lungwitz et al.   PHYSIOLOGY & BEHAVIOR

The calcium-activated slow AHP: cutting through the Gordian knot

(2012) Rodrigo Andrade et al.   Frontiers in Cellular Neuroscience

OX1orexin/hypocretin receptor activation of phospholipase D

(2011) MH Jäntti et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aberrant Expression of OX1 Receptors for Orexins in Colon Cancers and Liver Metastases: an Openable Gate to Apoptosis

(2011) T. Voisin et al.   CANCER RESEARCH

A ménage à trois made in heaven: G-protein-coupled receptors, lipids and TRP channels

(2011) Jyrki P. Kukkonen   CELL CALCIUM

Orexin Is Required for Brown Adipose Tissue Development, Differentiation, and Function

(2011) Dyan Sellayah et al.   Cell Metabolism

Orexin A stimulates glucose uptake, lipid accumulation and adiponectin secretion from 3T3-L1 adipocytes and isolated primary rat adipocytes

(2011) M. Skrzypski et al.   DIABETOLOGIA

Orexin Gene Transfer into Zona Incerta Neurons Suppresses Muscle Paralysis in Narcoleptic Mice

(2011) M. Liu et al.   JOURNAL OF NEUROSCIENCE

Differential Roles of Orexin Receptor-1 and -2 in the Regulation of Non-REM and REM Sleep

(2011) M. Mieda et al.   JOURNAL OF NEUROSCIENCE

Activation of Orexin 1 Receptors in the Periaqueductal Gray of Male Rats Leads to Antinociception via Retrograde Endocannabinoid (2-Arachidonoylglycerol)-Induced Disinhibition

(2011) Y.-C. Ho et al.   JOURNAL OF NEUROSCIENCE

Muscular effects of orexin A on the mouse duodenum: mechanical and electrophysiological studies

(2011) Roberta Squecco et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Role for Orexin in Central Vestibular Motor Control

(2011) Jun Zhang et al.   NEURON

Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids

(2011) Mahesh M. Karnani et al.   NEURON

Agonist ligand discrimination by the two orexin receptors depends on the expression system

(2011) Jaana Putula et al.   NEUROSCIENCE LETTERS

Mapping of the binding sites for the OX1 orexin receptor antagonist, SB-334867, using orexin/hypocretin receptor chimaeras

(2011) Jaana Putula et al.   NEUROSCIENCE LETTERS

Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice

(2011) T. Mochizuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-induced internalization of the orexin OX1 and cannabinoid CB1 receptors assessed via N-terminal SNAP and CLIP-tagging

(2010) Richard J Ward et al.   BRITISH JOURNAL OF PHARMACOLOGY

Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway

(2010) Lauri M. Louhivuori et al.   CELL CALCIUM

Characterization of GABAergic neurons in rapid-eye-movement sleep controlling regions of the brainstem reticular formation in GAD67-green fluorescent protein knock-in mice

(2010) Ritchie E. Brown et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ca2+-Dependent and Na+-Dependent K+ Conductances Contribute to a Slow AHP in Thalamic Paraventricular Nucleus Neurons: A Novel Target for Orexin Receptors

(2010) Li Zhang et al.   JOURNAL OF NEUROPHYSIOLOGY

Orexin Directly Excites Orexin Neurons through Orexin 2 Receptor

(2010) A. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

Functional Selectivity and Biased Receptor Signaling

(2010) T. Kenakin   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Orexins Depolarize Rostral Ventrolateral Medulla Neurons and Increase Arterial Pressure and Heart Rate in Rats Mainly via Orexin 2 Receptors

(2010) S.-C. Huang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cytosolic calcium elevation induced by orexin/hypocretin in granule cell domain cells of the rat cochlear nucleus in vitro

(2010) Yuki Nakamura et al.   PEPTIDES

Orexins/hypocretins control bistability of hippocampal long-term synaptic plasticity through co-activation of multiple kinases

(2009) O. Selbach et al.   Acta Physiologica

Activation of the basal forebrain by the orexin/hypocretin neurones

(2009) E. Arrigoni et al.   Acta Physiologica

Hypocretin/orexin increases the expression of steroidogenic enzymes in human adrenocortical NCI H295R cells

(2009) Jan Wenzel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Involvement of TRPC3 channels in calcium oscillations mediated by OX1 orexin receptors

(2009) Hanna M. Peltonen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of orexin/hypocretin in dependence and addiction

(2009) Ruth Sharf et al.   BRAIN RESEARCH

Arachidonic acid release mediated by OX1 orexin receptors

(2009) Pauli M Turunen et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Modulation of Orexin A on HCN Currents of Pyramidal Neurons in Mouse Prelimbic Cortex

(2009) B. Li et al.   CEREBRAL CORTEX

The brain hypocretins and their receptors: mediators of allostatic arousal

(2009) Matthew E Carter et al.   CURRENT OPINION IN PHARMACOLOGY

Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis

(2009) Aadil El Firar et al.   FASEB JOURNAL

Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: diverse roles for orexins A and B

(2009) Manjunath Ramanjaneya et al.   JOURNAL OF ENDOCRINOLOGY

Properties of a T-Type Ca2+Channel–Activated Slow Afterhyperpolarization in Thalamic Paraventricular Nucleus and Other Thalamic Midline Neurons

(2009) Li Zhang et al.   JOURNAL OF NEUROPHYSIOLOGY

Neuroendocrine Proopiomelanocortin Neurons Are Excited by Hypocretin/Orexin

(2009) C. Acuna-Goycolea et al.   JOURNAL OF NEUROSCIENCE

Orexin-A and ghrelin depolarize the same pedunculopontine tegmental neurons in rats: An in vitro study

(2009) Juhyon Kim et al.   PEPTIDES

Electrophysiological effects of orexin/hypocretin on nucleus accumbens shell neurons in rats: An in vitro study

(2009) Katsuyuki Mukai et al.   PEPTIDES

Orexin-A increases cell surface expression of AMPA receptors in the striatum

(2008) Hyun Sung Shin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple phospholipase activation by OX1 orexin/hypocretin receptors

(2008) L. Johansson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The signalling profile of recombinant human orexin-2 receptor

(2008) Jiyou Tang et al.   CELLULAR SIGNALLING

Orexin Receptor Antagonists: Medicinal Chemistry and Therapeutic Potential

(2008) Anthony Roecker et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Orexins Stimulate Steroidogenic Acute Regulatory Protein Expression through Multiple Signaling Pathways in Human Adrenal H295R Cells

(2008) Manjunath Ramanjaneya et al.   ENDOCRINOLOGY

SK channel blockade promotes burst firing in dorsal raphe serotonergic neurons

(2008) Nathalie Rouchet et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons

(2008) S. L. Borgland et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism

(2008) Thierry Voisin et al.   FASEB JOURNAL

Dual Orexin Actions on Dorsal Raphe and Laterodorsal Tegmentum Neurons: Noisy Cation Current Activation and Selective Enhancement of Ca2+ Transients Mediated by L-Type Calcium Channels

(2008) K. A. Kohlmeier et al.   JOURNAL OF NEUROPHYSIOLOGY

Hypocretin-1 Potentiates NMDA Receptor-Mediated Somatodendritic Secretion from Locus Ceruleus Neurons

(2008) X.-W. Chen et al.   JOURNAL OF NEUROSCIENCE

Orexin peptides enhance median preoptic nucleus neuronal excitability via postsynaptic membrane depolarization and enhancement of glutamatergic afferents

(2008) M. Kolaj et al.   NEUROSCIENCE

Acid-sensitive TASK-like K+ conductances contribute to resting membrane potential and to orexin-induced membrane depolarization in rat thalamic paraventricular nucleus neurons

(2008) P. Doroshenko et al.   NEUROSCIENCE

Reinvestigation of the effect of orexin A on catecholamine release from adrenal chromaffin cells

(2008) Xiao-wei Chen et al.   NEUROSCIENCE LETTERS

Electrophysiological effects of orexins/hypocretins on pedunculopontine tegmental neurons in rats: An in vitro study

(2008) Juhyon Kim et al.   PEPTIDES

Orexin-A Inhibits Glucagon Secretion and Gene Expression through a Foxo1-Dependent Pathway

(2007) Eva Göncz et al.   ENDOCRINOLOGY

Regulation of OX1 orexin/hypocretin receptor-coupling to phospholipase C by Ca2+ influx

(2006) L Johansson et al.   BRITISH JOURNAL OF PHARMACOLOGY