Article
Neurosciences
Alen Eapen, Diego Fernandez-Fernandez, John Georgiou, Zuner A. Bortolotto, Stafford Lightman, David E. Jane, Arturas Volianskis, Graham L. Collingridge
Summary: The study demonstrates the involvement of GluN2D-containing NMDARs in both short-term potentiation (STP) and long-term potentiation (LTP) in the mouse hippocampus, highlighting the important role of GluN2D subunits in synaptic plasticity.
Review
Biochemistry & Molecular Biology
Mohammad Zaki Bin Ibrahim, Amrita Benoy, Sreedharan Sajikumar
Summary: Synaptic plasticity refers to the malleability of biochemical structures between neurons, affecting learning and memory. Different forms of synaptic plasticity, such as LTP and LTD, play specific cognitive roles in reinforcement, relearning, and memory association. Apart from homosynaptic modifications, synapses can interact with each other, as described by the synaptic tagging and capture hypothesis (STC).
Article
Biochemistry & Molecular Biology
Tatyana Y. Postnikova, Sergey L. Malkin, Maria Zakharova, Ilya Smolensky, Olga E. Zubareva, Aleksey Zaitsev
Summary: Disruption of glutamate clearance in the synaptic cleft can lead to synaptic dysfunction and neurological diseases, potentially causing excitotoxicity. Increased glutamate clearance has been shown to reduce long-term synaptic potentiation (LTP). Treatment with the enhancer of glutamate transporter 1 expression, ceftriaxone, weakened LTP in the hippocampus of young rats, likely due to reduced spillover of glutamate leading to decreased activation of synapses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Tatyana Y. Postnikova, Dmitry V. Amakhin, Alina M. Trofimova, Natalia L. Tumanova, Nadezhda M. Dubrovskaya, Daria S. Kalinina, Anna A. Kovalenko, Anastasiia D. Shcherbitskaia, Dmitry S. Vasilev, Aleksey V. Zaitsev
Summary: Maternal hyperhomocysteinemia during pregnancy leads to memory impairments in rats, associated with reduced long-term potentiation (LTP) and altered NMDA receptor desensitization in the hippocampus. Expression of glutamate receptor subunits is unaffected except for GluN1. Additionally, delayed hippocampal maturation and decreased synaptopodin-positive spines were observed in offspring.
Article
Pharmacology & Pharmacy
Cem Suer, Nurbanu Yildiz, Ozlem Barutcu, Burak Tan, Nurcan Dursun
Summary: The study found that inhibiting guanylate cyclase can alter the phosphorylation state of tau protein in the dentate gyrus of the hippocampal formation, affecting induction of LTD but not LTP.
PHARMACOLOGICAL REPORTS
(2021)
Article
Pharmacology & Pharmacy
Wonseok Chang, Jihua An, Geun Hee Seol, Seung Ho Han, Jaeyong Yee, Sun Seek Min
Summary: Trans-anethole has neuroprotective effects and can positively influence synaptic plasticity, which suggests its potential for improving cognitive impairment caused by neurodegenerative diseases.
Article
Neurosciences
Yao Wang, Shate Xiang, Mengge Zhang, Jingjing Zhang, Xinghong Ding
Summary: In this study, it was found that prednisone acetate (PA) administered via intragastric administration (gavage) successfully induced hippocampal long-term potentiation (LTP) impairment more than corticosterone (CORT) injection. PA caused memory decline, granule cell loss, and lower levels of glutamic acid, N-methyl-D-aspartate receptors, and gamma-aminobutyric acid compared to CORT. Neuronal lesions in the dentate gyrus and reduced levels of Glu and NMDARs (especially NMDAR2A) were suggested as the underlying cause of LTP impairment.
Article
Multidisciplinary Sciences
P. Robin, T. Emmerich, A. Ismail, A. Nigues, Y. You, G. -H. Nam, A. Keerthi, A. Siria, A. K. Geim, B. Radha, L. Bocquet
Summary: Experiments reveal the emergence of memory in the transport of electrolytes across nanoscale channels, which lays the foundation for biomimetic computations.
Article
Endocrinology & Metabolism
Ozlem Barutcu, Cem Suer, Nurcan Dursun, Esra Tufan, Ezgi Aslan Gulpinar, Burak Tan
Summary: The discovery of insulin receptors in brain areas involved in learning and memory suggests that insulin signaling plays a role in regulating cognitive function. This study found that insulin can induce chemical plasticity and that carbohydrate syrup affects this process. These findings provide a mechanistic link between insulin and synaptic plasticity.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Neurosciences
Fouad Lemtiri-Chlieh, Eric S. Levine
Summary: It is widely accepted that exogenous cannabinoids can impair short-term memory and cognition. Conversely, the activation of endogenous cannabinoids may enhance synaptic plasticity. This study found that the simultaneous activation of CB1 receptors by 2-AG and anandamide enhances LTP by suppressing inhibition at GABAergic synapses.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Rolando Torrado-Arevalo, Julieta Troncoso, Alejandro Munera
Summary: Facial nerve axotomy induces changes in the central nervous system beyond facial motoneurons, affecting sensorimotor cortex and hippocampal-dependent memory tasks. In animal experiments, it was found that peripheral axotomy affects basal transmission and long-term plasticity of CA3-CA1 synapses, with enhanced release probability and impairment in long-term potentiation induction. These synaptic changes may explain impairments in hippocampal-dependent memory tasks and suggest a direct hippocampal involvement in sensorimotor integration.
Article
Neurosciences
Sahifeh Kazemi, Samaneh Safari, Somayeh Komaki, Seyed Asaad Karimi, Zoleikha Golipoor, Alireza Komaki
Summary: This study assessed the effects of carvacrol (CAR) and p-cymene on hippocampal long-term potentiation (LTP) in a rat model of Alzheimer's disease (AD). The results showed that CAR and p-cymene can ameliorate synaptic plasticity changes associated with AD, but their combination did not have the same effect.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Shruti Vishnoi, Sheikh Raisuddin, Suhel Parvez
Summary: This study found that strong training can form long-term memory, while weak training can lead to long-term memory formation when paired with another behavioral task. Glutamate and D1/D5 receptors play critical roles in the synthesis of learning tags and the arrival of plasticity-related proteins (PRPs).
Article
Multidisciplinary Sciences
Benjamin Compans, Come Camus, Emmanouela Kallergi, Silvia Sposini, Magalie Martineau, Corey Butler, Adel Kechkar, Remco Klaassen, Natacha Retailleau, Terrence J. Sejnowski, August B. Smit, Jean-Baptiste Sibarita, Thomas M. Bartol, David Perrais, Vassiliki Nikoletopoulou, Daniel Choquet, Eric Hosy
Summary: Long-term depression (LTD) of synaptic strength is associated with circuit remodeling, memory encoding, and erasure. P2XR- and NMDAR-dependent LTD are linked to distinct molecular modifications that lead to specific changes in synapse function.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Cristina D. Peterson, Jonathan J. Waataja, Kelley F. Kitto, Samuel J. Erb, Harsha Verma, Daniel J. Schuster, Caroline C. Churchill, Maureen S. Riedl, Lalitha R. Belur, Daniel A. Wolf, R. Scott McIvor, Lucy Vulchanova, George L. Wilcox, Carolyn A. Fairbanks
Summary: Chronic pain is a global burden with limited treatment options. In this study, the gene for arginine decarboxylase was delivered using an AAV vector and shown to alleviate chronic neuropathic pain in mice and rats without causing motor deficits. Agmatine, a product of this gene therapy, was found to modulate neuroplasticity associated with chronic pain, opening up potential non-opioid pain-relieving options.
Review
Physiology
K. S. Eriksson, O. A. Sergeeva, H. L. Haas, O. Selbach
Article
Gastroenterology & Hepatology
Boris Goerg, Natalia Qvartskhava, Verena Keitel, Hans J. Bidmon, Oliver Selbach, Freimut Schliess, Dieter Haeussinger
Article
Neurosciences
Antje Jilg, Sandra Lesny, Natalie Peruzki, Herbert Schwegler, Oliver Selbach, Faramarz Dehghani, Joerg H. Stehle
Article
Biochemistry & Molecular Biology
Aisa N. Chepkova, Oliver Selbach, Helmut L. Haas, Olga A. Sergeeva
JOURNAL OF NEUROCHEMISTRY
(2012)
Article
Neurosciences
Regis Parmentier, Sergej Kolbaev, Boris P. Klyuch, David Vandael, Jian-Sheng Lin, Oliver Selbach, Helmut L. Haas, Olga A. Sergeeva
JOURNAL OF NEUROSCIENCE
(2009)
Review
Physiology
Helmut L. Haas, Olga A. Sergeeva, Oliver Selbach
PHYSIOLOGICAL REVIEWS
(2008)
Meeting Abstract
Hematology
Ingmar Bruns, Patrick Cadeddu, Sebastian Buest, Boris Goerg, Johannes C. Fischer, Oliver Selbach, Ulrich Steidl, Ralf Kronenwett, Rainer Haas, Guido Kobbe, Akos Czibere
Article
Neurosciences
Roland Reinehr, Boris Goerg, Stephan Becker, Natalia Qvartskhava, Hans J. Bidmon, Oliver Selbach, Helmut L. Haas, Freimut Schliess, Dieter Haeussinger
Article
Gastroenterology & Hepatology
Verena Keitel, Roland Reinehr, Petros Gatsios, Claudia Rupprecht, Boris Goerg, Oliver Selbach, Dieter Haeussinger, Ralf Kubitz
Article
Multidisciplinary Sciences
S Berger, DP Wolfer, O Selbach, H Alter, G Erdmann, HM Reichardt, AN Chepkova, H Welzl, HL Haas, HP Lipp, G Schütz
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2006)
Article
Neurosciences
KS Eriksson, OA Sergeeva, O Selbach, HL Haas
EUROPEAN JOURNAL OF NEUROSCIENCE
(2004)
Article
Biology
O Selbach, HL Haas
CHRONOBIOLOGY INTERNATIONAL
(2006)
Article
Neurosciences
OA Sergeeva, D Schulz, N Doreulee, AA Ponomarenko, O Selbach, E Borsch, G Kircheis, JP Huston, D Haussinger, HL Haas
Article
Neurosciences
O Selbach, N Doreulee, C Bohla, KS Eriksson, OA Sergeeva, W Poelchen, RE Brown, HL Haas
Review
Physiology
Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.