期刊
CELL CALCIUM
卷 50, 期 1, 页码 9-26出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2011.04.005
关键词
Anandamide; Arachidonic acid; 2-Arachidonoylglycerol; Ceramide; Ceramide-1-phosphate; Cholesterol; Cyclooxygenase; Diacylglycerol; Diacylglycerol kinase; Diacylglycerol lipase; Eicosanoid; Endocannabinoid; Endovanilloid; Epoxygenase; Free fatty acid; Glycerophospholipid; G-protein-coupled receptor; 4-Hydroxy-2-nonenal; Inositol-1,4,5-trisphosphate; Lipase; Lipid; Lipid kinase; Lipid signaling; Lipoxygenase; Lysophosphatidic acid; Lysophosphatidylcholine; Monoacylglycerol lipase; Mustard oil; Phosphatidic acid; Phosphatidic acid phosphohydrolase; Phosphatidylcholine; Phosphatidylethanolamine; Phosphatidylinositol; Phosphatidylserine; Phosphoinositide-3-kinase; Phospholipase; Phospholipid; Platelet-activating factor; Prostaglandin; Sphingolipid; Sphingomyelin; Sphingosine; Sphingosine-1-phosphate; Sphingosylphosphotylcholine; TRP channel
类别
资金
- Academy of Finland
- Magnus Ehrnrooth Foundation
- University of Helsinki
Recent technical and conceptual advances in lipid analysis have given us a glimpse into the true versatility of the lipidome and the complexity of lipid signaling species. Progress alike in protein chemistry and genetics has presented us with new signal pathways and molecular mechanisms for the lipid actions. G-protein-coupled receptors (GPCR) appear to play a central role in the regulation of many lipid signals and are also themselves targets for some of these. TRP channels have recently been acknowledged as one of the most important GPCR effectors; in many cases the signals from GPCRs to TRPs are mediated via lipid signals. This review aims at presenting a view into the complex lipid signaling networks, their possible regulation by GPCRs and the signals transmitted to the TRP channels. Critical views and possible shortcomings in the composition of the studies are also presented. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据