PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity

Targeting the HGF/Met signalling pathway in cancer

(2010) Fabiola Cecchi et al.   EUROPEAN JOURNAL OF CANCER

Signalling to cancer cell invasion through PAK family kinases

(2010) Andrew Whale   Frontiers in Bioscience-Landmark

p21-activated Kinase 4 Phosphorylation of Integrin β5 Ser-759 and Ser-762 Regulates Cell Migration

(2010) Zhilun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

(2010) Rebecca W. Scott et al.   JOURNAL OF CELL BIOLOGY

PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion

(2010) C. M. Wells et al.   JOURNAL OF CELL SCIENCE

N-terminal interaction domain implicates PAK4 in translational regulation and reveals novel cellular localization signals

(2010) Simona Baldassa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Integrin-mediated Cell Attachment Induces a PAK4-dependent Feedback Loop Regulating Cell Adhesion through Modified Integrin αvβ5 Clustering and Turnover

(2010) Zhilun Li et al.   MOLECULAR BIOLOGY OF THE CELL

p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients

(2010) M. K. Y. Siu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

(2010) B. W. Murray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First-line therapy for chronic myeloid leukemia: Past, present, and future

(2009) Carolina Pavlovsky et al.   AMERICAN JOURNAL OF HEMATOLOGY

Targeting group II PAKs in cancer and metastasis

(2009) Jeyanthy Eswaran et al.   CANCER AND METASTASIS REVIEWS

Pak4, a Novel Gab1 Binding Partner, Modulates Cell Migration and Invasion by the Met Receptor

(2009) G. N. Paliouras et al.   MOLECULAR AND CELLULAR BIOLOGY

A Conserved Salt Bridge in the G Loop of Multiple Protein Kinases Is Important for Catalysis and for In Vivo Lyn Function

(2009) Rina Barouch-Bentov et al.   MOLECULAR CELL

Crosstalk in Met receptor oncogenesis

(2009) Andrea Z. Lai et al.   TRENDS IN CELL BIOLOGY

A PAK4–LIMK1 pathway drives prostate cancer cell migration downstream of HGF

(2008) Tasneem Ahmed et al.   CELLULAR SIGNALLING

Molecular Basis of Drug Resistance in Aurora Kinases

(2008) Fiona Girdler et al.   CHEMISTRY & BIOLOGY

Showering c-MET-dependent cancers with drugs

(2008) Beatrice S. Knudsen et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Arp2/3 complex interactions and actin network turnover in lamellipodia

(2008) Frank PL Lai et al.   EMBO JOURNAL

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

(2008) A. C. Kimmelman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA