Review article: the efficacy of biomarkers in chronic fibroproliferative diseases - early diagnosis and prognosis, with liver fibrosis as an exemplar

Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension

(2015) D. J. Leeming et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

(2014) Hannele Yki-Järvinen   Lancet Diabetes & Endocrinology

Value of biomarkers in osteoarthritis: current status and perspectives

(2013) M Lotz et al.   ANNALS OF THE RHEUMATIC DISEASES

Quantification of “end products” of tissue destruction in inflammation may reflect convergence of cytokine and signaling pathways – implications for modern clinical chemistry

(2013) Morten A. Karsdal et al.   BIOMARKERS

Liver Stiffness Is Associated With Risk of Decompensation, Liver Cancer, and Death in Patients With Chronic Liver Diseases: A Systematic Review and Meta-analysis

(2013) Siddharth Singh et al.   Clinical Gastroenterology and Hepatology

Evolving therapies for liver fibrosis

(2013) Detlef Schuppan et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-alcoholic steatohepatitis: Pathogenesis and novel therapeutic approaches

(2013) Detlef Schuppan et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Global burden of alcoholic liver diseases

(2013) Jürgen Rehm et al.   JOURNAL OF HEPATOLOGY

Liver fibrosis progression at autopsy in injecting drug users infected by hepatitis C: A longitudinal long-term cohort study

(2013) Knut Boe Kielland et al.   JOURNAL OF HEPATOLOGY

Meta-analysis: ARFI elastography versus transient elastography for the evaluation of liver fibrosis

(2013) Simona Bota et al.   LIVER INTERNATIONAL

Osteoarthritis – a case for personalized health care?

(2013) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Circulating Protein Fragments of Cartilage and Connective Tissue Degradation Are Diagnostic and Prognostic Markers of Rheumatoid Arthritis and Ankylosing Spondylitis

(2013) Anne C. Bay-Jensen et al.   PLoS One

Therapy for Fibrotic Diseases: Nearing the Starting Line

(2013) S. L. Friedman et al.   Science Translational Medicine

Serological identification of fast progressors of structural damage with rheumatoid arthritis

(2013) Anne Siebuhr et al.   ARTHRITIS RESEARCH & THERAPY

Serum markers of the extracellular matrix remodeling reflect antifibrotic therapy in bile-duct ligated rats

(2013) Robert Schierwagen et al.   Frontiers in Physiology

Circulating Citrullinated Vimentin Fragments Reflect Disease Burden in Ankylosing Spondylitis and Have Prognostic Capacity for Radiographic Progression

(2012) Anne C. Bay-Jensen et al.   ARTHRITIS AND RHEUMATISM

Extracellular Matrix Remodeling: The Common Denominator in Connective Tissue DiseasesPossibilities for Evaluation and Current Understanding of the Matrix as More Than a Passive Architecture, but a Key Player in Tissue Failure

(2012) Morten A. Karsdal et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Development of an immunoassay for the derived-peptide of chromogranin A, Vasostatin-I (1-76): assessment of severity in patients with sepsis

(2012) Hélène Chung et al.   BIOMARKERS

MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis

(2012) S.S. Veidal et al.   CLINICAL BIOCHEMISTRY

Prevalence and Natural History of Alcoholic Liver Disease

(2012) Jonathan M. Schwartz et al.   Clinics in Liver Disease

A -Val360: a marker of neutrophil elastase and COPD disease activity

(2012) R. I. Carter et al.   EUROPEAN RESPIRATORY JOURNAL

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

Accuracy of real-time shear wave elastography for assessing liver fibrosis in chronic hepatitis C: A pilot study

(2012) Giovanna Ferraioli et al.   HEPATOLOGY

Validation of terminal peptide of procollagen III for the detection and assessment of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease

(2012) Sudeep Tanwar et al.   HEPATOLOGY

Enzyme-linked immunosorbent serum assay specific for the 7S domain of Collagen Type IV (P4NP 7S): A marker related to the extracellular matrix remodeling during liver fibrogenesis

(2012) Diana J. Leeming et al.   HEPATOLOGY RESEARCH

Vasostatin-I, a chromogranin A-derived peptide, in non-selected critically ill patients: distribution, kinetics, and prognostic significance

(2012) Francis Schneider et al.   INTENSIVE CARE MEDICINE

Anti-fibrotic therapy: Lost in translation?

(2012) Detlef Schuppan et al.   JOURNAL OF HEPATOLOGY

Clinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker

(2012) Efstathios Vassiliadis et al.   Journal of Translational Medicine

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Stephen S Lim et al.   LANCET

Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study

(2012) Patrick Marcellin et al.   LANCET

Protein fingerprinting of the extracellular matrix remodelling in a rat model of liver fibrosis-a serological evaluation

(2012) Diana J. Leeming et al.   LIVER INTERNATIONAL

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

IgG4-Related Disease

(2012) John H. Stone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage

(2012) Valeria M Dejica et al.   ARTHRITIS RESEARCH & THERAPY

Extracellular Matrix and Fibroblast Communication Following Myocardial Infarction

(2012) Yonggang Ma et al.   Journal of Cardiovascular Translational Research

Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis

(2011) Efstathios Vassiliadis et al.   BIOMARKERS

A novel marker for assessment of liver matrix remodeling: An enzyme-linked immunosorbent assay (ELISA) detecting a MMP generated type I collagen neo-epitope (C1M)

(2011) DJ. Leeming et al.   BIOMARKERS

Protein fingerprints — Relying on and understanding the information of serological protein measurements

(2011) M.A. Karsdal et al.   CLINICAL BIOCHEMISTRY

Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM—Increased serum CIIM in subjects with severe radiographic osteoarthritis

(2011) Anne-Christine Bay-Jensen et al.   CLINICAL BIOCHEMISTRY

Macrophage activation governs schistosomiasis-induced inflammation and fibrosis

(2011) Luke Barron et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis – Identification and Validation of a Novel Biochemical Marker Assay

(2011) Sanne Skovgård Veidal et al.   PLoS One

Low liver stiffness among cirrhotic patients with hepatitis B after prolonged treatment with nucleoside analogs

(2011) Ellen Sloth Andersen et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

The fibrinogen cleavage product A -Val360, a specific marker of neutrophil elastase activity in vivo

(2011) R. I. Carter et al.   THORAX

Biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities

(2011) Morten A Karsdal et al.   ARTHRITIS RESEARCH & THERAPY

Current status of novel antifibrotic therapies in patients with chronic liver disease

(2011) Michal Cohen-Naftaly et al.   Therapeutic Advances in Gastroenterology

Macrophage-Mediated Proteolytic Remodeling of the Extracellular Matrix in Atherosclerosis Results in Neoepitopes: A Potential New Class of Biochemical Markers

(2010) Helene Skjøt-Arkil et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Enzyme-linked immunosorbent serum assays (ELISAs) for rat and human N-terminal pro-peptide of collagen type I (PINP) — Assessment of corresponding epitopes

(2010) D.J. Leeming et al.   CLINICAL BIOCHEMISTRY

A novel assay for extracellular matrix remodeling associated with liver fibrosis: An enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed neo-epitope of type III collagen

(2010) N. Barascuk et al.   CLINICAL BIOCHEMISTRY

Novel combinations of Post-Translational Modification (PTM) neo-epitopes provide tissue-specific biochemical markers—are they the cause or the consequence of the disease?

(2010) Morten Asser Karsdal et al.   CLINICAL BIOCHEMISTRY

M30 Neoepitope Expression in Epithelial Cancer: Quantification of Apoptosis in Circulating Tumor Cells by CellSearch Analysis

(2010) E. Rossi et al.   CLINICAL CANCER RESEARCH

Lower liver stiffness in patients with sustained virological response 4 years after treatment for chronic hepatitis C

(2010) Ellen Sloth Andersen et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Reduced Mortality Rates Following Elective Percutaneous Liver Biopsies

(2010) Joe West et al.   GASTROENTEROLOGY

Ectodomain Shedding Generates Neoepitopes on Collagen XVII, the Major Autoantigen for Bullous Pemphigoid

(2010) W. Nishie et al.   JOURNAL OF IMMUNOLOGY

Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis

(2010) Sanne S. Veidal et al.   LIVER INTERNATIONAL

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Biochemical markers and the FDA Critical Path: How biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development

(2009) M.A. Karsdal et al.   BIOMARKERS

Influence of food intake on the bioavailability and efficacy of oral calcitonin

(2009) Morten A. Karsdal et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The clinical use of HVPG measurements in chronic liver disease

(2009) Jaime Bosch et al.   Nature Reviews Gastroenterology & Hepatology

Serum concentrations of formation (PINP) and resorption (Ctx) bone turnover markers in rheumatoid arthritis

(2009) Margaret Wisłowska et al.   RHEUMATOLOGY INTERNATIONAL

Identification of progressors in osteoarthritis by combining biochemical and MRI-based markers

(2009) Erik B Dam et al.   ARTHRITIS RESEARCH & THERAPY

Variation in osteoarthritis biomarkers from activity not food consumption

(2008) Craig D. Gordon et al.   CLINICA CHIMICA ACTA

Magnetic Resonance Elastography for the Noninvasive Staging of Liver Fibrosis

(2008) Laurent Huwart et al.   GASTROENTEROLOGY

Performance of Transient Elastography for the Staging of Liver Fibrosis: A Meta-Analysis

(2008) Mireen Friedrich–Rust et al.   GASTROENTEROLOGY

Liver biopsy

(2008) Don C. Rockey et al.   HEPATOLOGY

Liver cirrhosis

(2008) Detlef Schuppan et al.   LANCET

Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21 months by MRI

(2008) E.B. Dam et al.   OSTEOARTHRITIS AND CARTILAGE

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Evaluation of serum CC-16 as a biomarker for COPD in the ECLIPSE cohort

(2008) D A Lomas et al.   THORAX

Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity

(2008) Morten A Karsdal et al.   ARTHRITIS RESEARCH & THERAPY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY