Article
Medicine, General & Internal
Jane B. Maoga, Muhammad A. Riaz, Agnes N. Mwaura, Georgios Scheiner-Bobis, Ezekiel Mecha, Charles O. A. Omwandho, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: Matrix metalloproteinases (MMPs) play an important role in menstruation and endometriosis. The expression of MT2-MMP and MT3-MMP proteins varies in different types of endometrial tissues.
Article
Biochemistry & Molecular Biology
Xiao-dan Xia, Govind Gill, Haiming Lin, Daniela M. Roth, Xiang-jiang Wang, Feng-yi Su, Adekunle Alabi, Maria Alexiou, Ziyang Zhang, Gui-qing Wang, Daniel Graf, Da-wei Zhang
Summary: Membrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, including severe inflammatory arthritis. The deficiency of MT1-MMP leads to noticeable joint swelling and severe arthritis in adult mice. Targeting specific cell types for MT1-MMP inhibition may be crucial for potential therapeutic use in arthritis.
Article
Biochemistry & Molecular Biology
Joachim C. Manning, Veronica Baldoneschi, Laura L. Romero-Hern, Katharina M. Pichler, Gabriel GarcIa Caballero, Sabine Andr, Tanja J. Kutzner, Anna-Kristin Ludwig, Valerio Zullo, Barbara Richichi, Reinhard Windhager, Herbert Kaltner, Stefan Toegel, Hans-Joachim Gabius, Paul V. Murphy, Cristina Nativi
Summary: Pairing glycans with tissue lectins can regulate multiple effector pathways in (patho)physiology, and it is particularly important in the progression of osteoarthritis. Designing inhibitors that can block galectin binding and matrix metalloproteinases (MMPs) has the potential to dissect the roles of lectins and proteolytic enzymes. Testing these inhibitors on clinical material has shown promising results in reducing galectin binding to osteoarthritis specimens.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Qunshan Lu, Peilai Liu, Zhuang Miao, Desu Luo, Songlin Li, Mei Lu
Summary: Our study demonstrates that SIRT1 can inhibit EGFR ubiquitination by down-regulating PTEN, thereby preventing extracellular matrix degradation and activating chondrocyte autophagy. Knockdown of SIRT1 accelerates the progression of osteoarthritis in the pathological process.
CELL DEATH DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Ting Li, Jie Peng, Qingqing Li, Yuan Shu, Peijun Zhu, Liang Hao
Summary: This article primarily reviews the role of ADAMTS metalloproteinases in osteoarthritis. It explains how ADAMTS participates in ECM, cartilage degeneration, and synovial inflammation, which are all aspects of osteoarthritis. This article may provide a theoretical basis for the study of new therapeutic methods for osteoarthritis.
Article
Endocrinology & Metabolism
Lian Duan, Shengmin Yang, Lin Jie Wang, Yuelun Zhang, Ran Li, Hongbo Yang, Yuxing Zhao, Hanze Du, Xiao Zhai, Fengying Gong, Hui Pan, Huijuan Zhu, Weibo Xia
Summary: This study evaluated bone turnover markers and bone microarchitecture parameters in patients with active and controlled acromegaly. It found that controlled patients had slower bone turnover but did not necessarily have better bone microstructure compared to active patients. Overall, acromegaly adversely affected bone quality, even in controlled patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Hematology
Hannah Slovacek, Rajan Khanna, Pavel Poredos, Peter Poredos, Mateja Jezovnik, Debra Hoppensteadt, Jawed Fareed, William Hopkinson
Summary: This study elucidated the immediate post-operative changes in levels of PRG4, MMP-9, IL-6, CRP, and WBC in patients undergoing TJA, showing the crucial role of inflammation in recovery after surgery and in the overall pathogenesis of OA. The biomarkers measured may help risk stratify patients pre-operatively and develop individualized post-surgical plans.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2021)
Article
Orthopedics
A. Singh, A. Venn, L. Blizzard, G. Jones, J. Burgess, V Parameswaran, F. Cicuttini, L. March, F. Eckstein, W. Wirth, C. Ding, B. Antony
Summary: The study found that levels of COMP and MMP-3 were negatively associated with knee cartilage thickness and volume, and MRI markers assessed at different time points were also correlated with biochemical markers.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Orthopedics
Karan Vishwanath, Scott R. McClure, Lawrence J. Bonassar
Summary: This study characterized the lubricating ability of pAAm hydrogel and revealed its effectiveness in lubricating both native and degraded cartilage explants, suggesting an affinity for the articulating surface of the cartilage.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Christian Jacoby, Malina Goerke, Dominik Bezold, Henning Jessen, Matthias Boll
Summary: The study identified an ATP-dependent 25-hydroxy-steroid kinase (25-HSK) from anaerobic bacteria, which plays a crucial role in the degradation of zoo- and phytosterols. This enzyme shows little similarity to known phosphotransferases and has a high phosphoryl transfer potential for tertiary steroid C25-phosphoesters.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Engineering, Biomedical
Allison Mixon, Ahmed Suparno Bahar-Moni, Tanvir R. Faisal
Summary: Matrix metalloproteinases (MMPs) degrade the extracellular matrix (ECM) subsequently damaging cartilage and altering biomechanical properties. Individually, MMP-1 and MMP-9 have minimal effect on cartilage micromechanical properties, but synergistically the two enzymes digest ECM components and result in a greater degradative effect.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Integrative & Complementary Medicine
Zhen Li, Zhenyue Chen, Jiayi Chen, Zhutong Liu, Zehui Li, He Sun, Xiaochao Wang, Jinqiang Wei, Xuewei Cao, Decai Zheng
Summary: This study found that monotropein (MON), the main active ingredient of Morinda officinalis F.C. How, has therapeutic effects on chondrocytes and a mouse model of OA. It alleviates OA progression by inhibiting cartilage matrix degradation, apoptosis, and pyroptosis of chondrocytes through NF-kappa B pathway inactivation. MON shows promise as an alternative treatment for OA.
Article
Multidisciplinary Sciences
Narumi Nakada-Honda, Dan Cui, Satoshi Matsuda, Eiji Ikeda
Summary: The administration of cyclophilin A (CypA) can artificially open the blood-brain barrier, allowing for easier delivery of systemically administered therapeutic drugs into neural tissues. This method showed transient and reversible effects in mouse experiments.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
S-H Li, Q-F Wu
Summary: MicroRNAs (miRNAs) are associated with the pathogenesis of KOA by regulating cartilage homeostasis through targeting ECM degradation via corresponding upstream/downstream mechanisms.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Orthopedics
Omid Sadatpour, Mohammad Taha Ebrahimi, Maryam Akhtari, Nooshin Ahmadzadeh, Mahdi Vojdanian, Ahmadreza Jamshidi, Elham Farhadi, Mahdi Mahmoudi
Summary: The study found that A(2A)AR activation cannot reduce MMP8 expression in patients' macrophages, while it can in healthy macrophages. The effect of A(2A)AR activation on BMP2 and MMP9 expression did not reach statistical significance in either healthy macrophages or the patients' group. Additionally, a significant positive correlation was discovered between MMP8 expression and patient scores on the BASFI.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Gastroenterology & Hepatology
Ferenc Emil Mozes, Jenny A. Lee, Emmanuel Anandraj Selvaraj, Arjun Narayan Ajmer Jayaswal, Michael Trauner, Jerome Boursier, Celine Fournier, Katharina Staufer, Rudolf E. Stauber, Elisabetta Bugianesi, Ramy Younes, Silvia Gaia, Monica Lupsor-Platon, Salvatore Petta, Toshihide Shima, Takeshi Okanoue, Sanjiv Mahadeva, Wah-Kheong Chan, Peter J. Eddowes, Gideon M. Hirschfield, Philip Noel Newsome, Vincent Wai-Sun Wong, Victor de Ledinghen, Jiangao Fan, Feng Shen, Jeremy F. Cobbold, Yoshio Sumida, Akira Okajima, Joern M. Schattenberg, Christian Labenz, Won Kim, Myoung Seok Lee, Johannes Wiegand, Thomas Karlas, Yusuf Yilmaz, Guruprasad Padur Aithal, Naaventhan Palaniyappan, Christophe Cassinotto, Sandeep Aggarwal, Harshit Garg, Geraldine J. Ooi, Atsushi Nakajima, Masato Yoneda, Marianne Ziol, Nathalie Barget, Andreas Geier, Theresa Tuthill, M. Julia Brosnan, Quentin Mark Anstee, Stefan Neubauer, Stephen A. Harrison, Patrick M. Bossuyt, Michael Pavlides
Summary: Liver biopsy is still necessary for fibrosis staging in patients with non-alcoholic fatty liver disease. This study evaluated the diagnostic performance of liver stiffness measurement, FIB-4 Index, and NAFLD Fibrosis Score, and showed that sequential combinations of markers can reduce the need for liver biopsies.
Article
Transplantation
Nadja Sparding, Federica Genovese, Daniel Guldager Kring Rasmussen, Morten Asser Karsdal, Michaela Neprasova, Dita Maixnerova, Veronika Satrapova, Doubravka Frausova, Mads Hornum, Lenka Bartonova, Eva Honsova, Marek Kollar, Helena Koprivova, Zdenka Hruskova, Vladimir Tesar
Summary: This study found that levels of circulating and excreted ETP are associated with kidney function, CKD severity, and the extent of interstitial fibrosis, gradually increasing with higher fibrotic burden. ETP outperformed the known fibrosis biomarker Dickkopf-3 in discriminating patients with high fibrotic burden.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Orthopedics
V. B. Kraus, M. A. Karsdal
Summary: This article provides an overview of biomarkers for osteoarthritis (OA) and aims to equip non-specialists with a toolbox to understand and utilize biomarkers in the field of OA. Although the importance of molecular biomarkers in OA has been increasingly recognized, no OA-related biomarkers have been widely adopted in clinical practice. However, there is a growing compendium of OA-related biomarkers that could facilitate drug development for OA. The use of appropriate biomarkers is crucial for OA diagnosis, prognosis, drug development, and treatment.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Rheumatology
Salome Kristensen, Signe Holm Nielsen, Erik Berg Schmidt, Anne Christine Bay-Jensen, Morten A. Karsdal, Jeppe Hagstrup Christensen
Summary: The study found that there was no significant correlation between the content of fatty acids in granulocytes and disease activity in patients with psoriatic arthritis (PsA). However, marine n-3 PUFA was positively correlated with collagen degradation, while n-6 PUFA was positively correlated with collagen formation. Further investigation is needed to explore the relationship between fatty acids and biomarkers of bone and soft tissue turnover.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Majken Lindholm, Antonio Di Sabatino, Tina Manon-Jensen, Giuseppe Mazza, Gunvor Madsen, Paolo Giuffrida, Massimo Pinzani, Aleksander Krag, Morten A. Karsdal, Jens Kjeldsen, Joachim H. Mortensen
Summary: The study demonstrated that serum LG1M levels were elevated in CD patients compared to healthy subjects, indicating a possible association with laminin degradation. In DSS-induced colitis rats, LG1M levels increased upon disease reversal, suggesting ongoing mucosal repair.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Endocrinology & Metabolism
Sami Qadri, Noora Ahlholm, Ida Lonsmann, Paola Pellegrini, Anni Poikola, Panu K. Luukkonen, Kimmo Porthan, Anne Juuti, Henna Sammalkorpi, Anne K. Penttila, Roberta D'Ambrosio, Giorgio Soardo, Diana J. Leeming, Morten Karsdal, Johanna Arola, Stergios Kechagias, Serena Pelusi, Mattias Ekstedt, Luca Valenti, Hannes Hagstrom, Hannele Yki-Jarvinen
Summary: This study investigated the impact of obesity on the performance of liver fibrosis biomarkers in NAFLD and found that ADAPT and FIB-4 are the best-performing biomarkers in obese patients, unaffected by body mass index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Liang-Jie Tang, Hong-Lei Ma, Mohammed Eslam, Grace Lai-Hung Wong, Pei-Wu Zhu, Sui-Dan Chen, Diana Julie Leeming, Morten Karsdal, Gang Li, Ou-Yang Huang, Howard Ho-Wai Leung, Yu-Jie Zhou, Qian Feng, Pei Jiang, Li-Mei Gao, Christopher D. Byrne, Giovanni Targher, Jacob George, Vincent Wai-Sun Wong, Ming-Hua Zheng
Summary: This study evaluated the performance of new biomarkers and algorithms for diagnosing advanced fibrosis in an Asian population. The results showed that the ADAPT score had good accuracy and sensitivity in diagnosing advanced fibrosis, and it outperformed other non-invasive fibrosis biomarkers. The ADAPT score also had good diagnostic performance in subgroup analyses.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Cardiac & Cardiovascular Systems
Dania Al-Sharify, Signe Holm Nielsen, Frank Matthes, Christoffer Tengryd, Jiangming Sun, Federica Genovese, Morten A. Karsdal, Jan Nilsson, Isabel Goncalves, Andreas Edsfeldt
Summary: This study investigated the association of cleaved osteoglycin with plaque phenotype and found that higher levels of cleaved osteoglycin were associated with a stable plaque phenotype and lower risk for future cardiovascular events. This association may be due to reduced cell apoptosis and the ability to retain LDL. Targeting the cleavage of osteoglycin may be a potential therapeutic strategy to stabilize plaques.
Article
Rheumatology
Signe Holm Nielsen, Andrew Stahly, Emilie H. Regner, Anne -Christine Bay-Jensen, Morten A. Karsdal, Kristine A. Kuhn
Summary: This study investigated the association between biomarkers of collagen degradation in healthy controls and patients with axSpA, CD, and CD-axSpA. The results showed that degradation of type IV collagen, quantified by C4M, could completely differentiate patients with CD-axSpA from axSpA, CD, and healthy controls, indicating excessive collagen degradation and epithelial turnover. This biomarker has the potential to identify patients affected by both diseases and guide treatment decisions.
JOURNAL OF RHEUMATOLOGY
(2022)
Letter
Dermatology
Signe Holm Nielsen, Solveig Skovlund Groen, Yiqiu Yao, Astrid-Helene Ravn Jorgensen, Valdemar Wendelboe Nielsen, Morten Karsdal, Kristoffer Gehring, Anne-Christine Bay-Jensen, Simon Francis Thomsen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Transplantation
Daan Kremer, Firas F. Alkaff, Adrian Post, Tim J. Knobbe, Martin Tepel, Olivier Thaunat, Stefan P. Berger, Jacob van den Born, Federica Genovese, Morten A. Karsdal, Daniel G. K. Rasmussen, Stephan J. L. Bakker, Behalf Transplant Lines Investigators
Summary: This study found a strong association between plasma endotrophin and graft failure and mortality in kidney transplant recipients. The findings suggest that abnormal extracellular matrix turnover and fibrosis play a key role in the prognosis of kidney transplant recipients and highlight the need for interventional studies targeting the profibrotic state of these patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Mette J. Nielsen, Grace E. Dolman, Rebecca Harris, Peder Frederiksen, Jane Chalmers, Jane I. Grove, William L. Irving, Morten A. Karsdal, Keyur Patel, Diana Julie Leeming, Indra Neil Guha
Summary: This study investigated the prognostic value of the fibrogenesis marker PRO-C3 and the ALBI score in predicting clinical outcomes and mortality in two cohorts of compensated cirrhosis patients. The results showed that both PRO-C3 and ALBI were independently associated with liver-related clinical outcomes, suggesting that PRO-C3 may be a valuable predictor of treatment efficacy.
Article
Gastroenterology & Hepatology
Morten A. Karsdal, Kate Hallsworth, Jadine Scragg, Diana J. Leeming, Ida F. Villesen, Leah Avery, Laura Haigh, Olivier Govaere, Sarah Wichmann, Guy Taylor, Sophie Cassidy, Stuart Mcpherson, Quentin M. Anstee
Summary: The amount of fibroblast activity in patients with NAFLD can be defined by circulating biomarkers of collagen formation. The high-risk, high-fibrogenesis patient endotype with greater fibroblast activity exhibited a marked reduction in collagen fibrogenesis with a very low-calorie diet intervention, while fibrogenesis remained unchanged in the low activity group. The quantification of fibrogenesis biomarkers at baseline can predict the likelihood of treatment response.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Urology & Nephrology
Nadja Sparding, Daniel Guldager Kring Rasmussen, Federica Genovese, Morten Asser Karsda, Mads Hornum, Bo Feldt-Rasmussen, Rebecca Packington, Nicholas M. Selby
Summary: This study found that levels of plasma ETP were higher in patients with acute kidney injury (AKI) at 1 year compared to those without AKI, and ETP levels predicted kidney disease progression and mortality in AKI patients.
Article
Gastroenterology & Hepatology
Katherine Johnson, Peter J. Leary, Olivier Govaere, Matthew J. Barter, Sarah H. Charlton, Simon J. Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M. Julia Brosnan, Jeremy F. Cobbold, Mattias Ekstedt, Guruprasad P. Aithal, Karine Clement, Joern M. Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M. Anstee, Ann K. Daly
Summary: The study found that serum miR-193a-5p levels are strongly correlated with NAFLD activity grade and fibrosis stage. MiR-193a-5p may play a role in the hepatic response to oxidative stress and is a potential circulating biomarker for progressive NAFLD.