Extracellular Matrix Remodeling: The Common Denominator in Connective Tissue DiseasesPossibilities for Evaluation and Current Understanding of the Matrix as More Than a Passive Architecture, but a Key Player in Tissue Failure

Serum Markers of Liver Fibrosis: Combining the BIPED Classification and the Neo-Epitope Approach in the Development of New Biomarkers

(2013) Sanne Skovgård Veidal et al.   DISEASE MARKERS

Antibodies binding to citrullinated telopeptides of type I and type II collagens and to mutated citrullinated vimentin synergistically predict the development of seropositive rheumatoid arthritis

(2012) Marja-Kaisa Koivula et al.   ANNALS OF THE RHEUMATIC DISEASES

MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis

(2012) S.S. Veidal et al.   CLINICAL BIOCHEMISTRY

Conformational switch of a flexible loop in human laminin receptor determines laminin-1 interaction

(2012) Carmen Di Giovanni et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Expression of 67-kDa laminin receptor was associated with tumor progression and poor prognosis in epithelial ovarian cancer

(2012) Taejong Song et al.   GYNECOLOGIC ONCOLOGY

Enzyme-linked immunosorbent serum assay specific for the 7S domain of Collagen Type IV (P4NP 7S): A marker related to the extracellular matrix remodeling during liver fibrogenesis

(2012) Diana J. Leeming et al.   HEPATOLOGY RESEARCH

Clinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker

(2012) Efstathios Vassiliadis et al.   Journal of Translational Medicine

Alterations of serum protein N-glycosylation in two mouse models of chronic liver disease are hepatocyte and not B cell driven

(2011) Bram Blomme et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Tumor Necrosis Factor-Alpha and Receptor Activator of Nuclear Factor-κB Ligand Augment Human Macrophage Foam-Cell Destruction of Extracellular Matrix Through Protease-Mediated Processes

(2011) Helene Skjøt-Arkil et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Invasive and non-invasive methods for the assessment of fibrosis and disease progression in chronic liver disease

(2011) Laurent Castera   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Post-translational modifications of the extracellular matrix are key events in cancer progression: Opportunities for biochemical marker development

(2011) D. J. Leeming et al.   BIOMARKERS

Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis

(2011) Efstathios Vassiliadis et al.   BIOMARKERS

A novel marker for assessment of liver matrix remodeling: An enzyme-linked immunosorbent assay (ELISA) detecting a MMP generated type I collagen neo-epitope (C1M)

(2011) DJ. Leeming et al.   BIOMARKERS

Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane

(2011) M. Bignon et al.   BLOOD

Development and validation of an enzyme-linked immunosorbent assay for the quantification of a specific MMP-9 mediated degradation fragment of type III collagen—A novel biomarker of atherosclerotic plaque remodeling

(2011) Natasha Barascuk et al.   CLINICAL BIOCHEMISTRY

Protein fingerprints — Relying on and understanding the information of serological protein measurements

(2011) M.A. Karsdal et al.   CLINICAL BIOCHEMISTRY

Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM—Increased serum CIIM in subjects with severe radiographic osteoarthritis

(2011) Anne-Christine Bay-Jensen et al.   CLINICAL BIOCHEMISTRY

Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas

(2011) Gema Moreno-Bueno et al.   EMBO Molecular Medicine

The potential for LOXL2 as a target for future cancer treatment

(2011) Holly E Barker et al.   Future Oncology

Fibromodulin, an Oxidative Stress-Sensitive Proteoglycan, Regulates the Fibrogenic Response to Liver Injury in Mice

(2011) Elisabetta Mormone et al.   GASTROENTEROLOGY

Pseudoachondroplasia and multiple epiphyseal dysplasia: A 7-year comprehensive analysis of the known disease genes identify novel and recurrent mutations and provides an accurate assessment of their relative contribution

(2011) Gail C. Jackson et al.   HUMAN MUTATION

COL6A1Gene and Ironman Triathlon Performance

(2011) K. O’Connell et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

Deficiency of Biglycan Causes Cardiac Fibroblasts to Differentiate into a Myofibroblast Phenotype

(2011) Ariane Melchior-Becker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrating mechanisms of pulmonary fibrosis

(2011) Thomas A. Wynn   JOURNAL OF EXPERIMENTAL MEDICINE

Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44

(2011) Yuejuan Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Schmid-type metaphyseal chondrodysplasia as the result of a collagen type X defect due to a novel COL10A1 nonsense mutation

(2011) Julia V. Woelfle et al.   JOURNAL OF ORTHOPAEDIC SCIENCE

The collagen VI-related myopathies: muscle meets its matrix

(2011) Carsten G. Bönnemann   Nature Reviews Neurology

Tendon Is Covered by a Basement Membrane Epithelium That Is Required for Cell Retention and the Prevention of Adhesion Formation

(2011) Susan H. Taylor et al.   PLoS One

MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis – Identification and Validation of a Novel Biochemical Marker Assay

(2011) Sanne Skovgård Veidal et al.   PLoS One

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrocytes in chronic lung disease – Facts and controversies

(2011) Shyam S. Maharaj et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Biochemical markers of ongoing joint damage in rheumatoid arthritis - current and future applications, limitations and opportunities

(2011) Morten A Karsdal et al.   ARTHRITIS RESEARCH & THERAPY

Integrins and their ligands in rheumatoid arthritis

(2011) Torsten Lowin et al.   ARTHRITIS RESEARCH & THERAPY

Extracellular Matrix Dynamics in Hepatocarcinogenesis: a Comparative Proteomics Study of PDGFC Transgenic and Pten Null Mouse Models

(2011) Keane K. Y. Lai et al.   PLoS Genetics

ColVI myopathies: where do we stand, where do we go?

(2011) Valérie Allamand et al.   Skeletal Muscle

Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis

(2010) Harold R. Collard et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Macrophage-Mediated Proteolytic Remodeling of the Extracellular Matrix in Atherosclerosis Results in Neoepitopes: A Potential New Class of Biochemical Markers

(2010) Helene Skjøt-Arkil et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

A Quantitative Assay for Lysosomal Acidification Rates in Human Osteoclasts

(2010) Vicki Kaiser Jensen et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Macrophages exposed to hypoxia secrete proteoglycans for which LDL has higher affinity

(2010) Annika Asplund et al.   ATHEROSCLEROSIS

A family with a new elastin gene mutation: broad clinical spectrum, including sudden cardiac death

(2010) André Jakob et al.   CARDIOLOGY IN THE YOUNG

Basement membrane components are key players in specialized extracellular matrices

(2010) Jenny Kruegel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A novel assay for extracellular matrix remodeling associated with liver fibrosis: An enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed neo-epitope of type III collagen

(2010) N. Barascuk et al.   CLINICAL BIOCHEMISTRY

Novel combinations of Post-Translational Modification (PTM) neo-epitopes provide tissue-specific biochemical markers—are they the cause or the consequence of the disease?

(2010) Morten Asser Karsdal et al.   CLINICAL BIOCHEMISTRY

Anthocyanins isolated from the purple-fleshed sweet potato attenuate the proliferation of hepatic stellate cells by blocking the PDGF receptor

(2010) Jae Ho Choi et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Degradation of tropoelastin by matrix metalloproteinases - cleavage site specificities and release of matrikines

(2010) Andrea Heinz et al.   FEBS Journal

Col4a1 mutation in mice causes defects in vascular function and low blood pressure associated with reduced red blood cell volume

(2010) Tom Van Agtmael et al.   HUMAN MOLECULAR GENETICS

Modulation of Lysyl Oxidase-like 2 Enzymatic Activity by an Allosteric Antibody Inhibitor

(2010) Hector M. Rodriguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early-onset metaphyseal chondrodysplasia type Schmid associated with a COL10A1 frame-shift mutation and impaired trimerization of wild-type α1(X) protein chains

(2010) Outi Mäkitie et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Matrix metalloproteinase-9-mediated type III collagen degradation as a novel serological biochemical marker for liver fibrogenesis

(2010) Sanne S. Veidal et al.   LIVER INTERNATIONAL

Glucocorticoid up-regulates mimecan expression in corticotroph cells

(2010) Qin-Yun Ma et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin

(2010) Young-Mi Kim et al.   MOLECULAR BIOLOGY REPORTS

Serum N-glycome biomarker for monitoring development of DENA-induced hepatocellular carcinoma in rat

(2010) Meng Fang et al.   Molecular Cancer

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Immunoglobulins are the major glycoproteins involved in the modifications of total serumN-glycome in cirrhotic patients

(2010) André Klein et al.   Proteomics Clinical Applications

Macrophages: Master Regulators of Inflammation and Fibrosis

(2010) Thomas Wynn et al.   SEMINARS IN LIVER DISEASE

Drugs of Abuse That Mediate Advanced Glycation End Product Formation: A Chemical Link to Disease Pathology

(2009) Jennifer B. Treweek et al.   ACCOUNTS OF CHEMICAL RESEARCH

Systematic review: caspase-cleaved fragments of cytokeratin 18 - the promises and challenges of a biomarker for chronic liver disease

(2009) Y. YILMAZ   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Circulating Fibrocytes Are an Indicator of Poor Prognosis in Idiopathic Pulmonary Fibrosis

(2009) Antje Moeller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mitochondrial Metabolism and Cancer

(2009) Frank Weinberg et al.   Annals of the New York Academy of Sciences

Extracellular/Microenvironmental Redox State

(2009) Luksana Chaiswing et al.   ANTIOXIDANTS & REDOX SIGNALING

Biochemical Markers of Joint Tissue Turnover

(2009) Anne-Christine Bay-Jensen et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Peptidylarginine deiminase 4 and citrullination in health and disease

(2009) Consuelo Anzilotti et al.   AUTOIMMUNITY REVIEWS

Application of biochemical markers in development of drugs for treatment of osteoarthritis

(2009) Per Qvist et al.   BIOMARKERS

The role of oxidative stress in the biological responses of lung epithelial cells to cigarette smoke

(2009) Stephen P. Faux et al.   BIOMARKERS

Biochemical markers and the FDA Critical Path: How biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development

(2009) M.A. Karsdal et al.   BIOMARKERS

Increased PADI4 expression in blood and tissues of patients with malignant tumors

(2009) Xiaotian Chang et al.   BMC CANCER

Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways

(2009) A. J. Schetter et al.   CARCINOGENESIS

Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway

(2009) Liang Peng et al.   CARCINOGENESIS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Basement membranes and human disease

(2009) Tom Van Agtmael et al.   CELL AND TISSUE RESEARCH

The receptor RAGE: Bridging inflammation and cancer

(2009) Astrid Riehl et al.   Cell Communication and Signaling

Novel roles for GAPDH in cell death and carcinogenesis

(2009) A Colell et al.   CELL DEATH AND DIFFERENTIATION

Elevation of the glycoxidation product Nε-(carboxymethyl)lysine in patients presenting with acute myocardial infarction

(2009) Stefan Kralev et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Low Serum Level of the Endogenous Secretory Receptor for Advanced Glycation End Products (esRAGE) Is a Risk Factor for Prevalent Vertebral Fractures Independent of Bone Mineral Density in Patients With Type 2 Diabetes

(2009) M. Yamamoto et al.   DIABETES CARE

Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver

(2009) L. Elli et al.   DIGESTIVE AND LIVER DISEASE

RAS in cellular transformation and senescence

(2009) Gina M. DeNicola et al.   EUROPEAN JOURNAL OF CANCER

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cells in 3D matrices under interstitial flow: Effects of extracellular matrix alignment on cell shear stress and drag forces

(2009) John A. Pedersen et al.   JOURNAL OF BIOMECHANICS

Decorin is a novel antagonistic ligand of the Met receptor

(2009) Silvia Goldoni et al.   JOURNAL OF CELL BIOLOGY

Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems

(2009) Jian-Ming Lü et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pentosidine and Increased Fracture Risk in Older Adults with Type 2 Diabetes

(2009) Ann V. Schwartz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Angiogenesis in liver disease

(2009) Mercedes Fernández et al.   JOURNAL OF HEPATOLOGY

Characterization of Anti-Advanced Glycation End Product Antibodies to Nonenzymatically Lysine-Derived and Arginine-Derived Glycated Products

(2009) Yeong-Gon Choi et al.   JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY

GlycoFibroTest Is a Highly Performant Liver Fibrosis Biomarker Derived from DNA Sequencer-based Serum Protein Glycomics

(2009) Dieter Vanderschaeghe et al.   MOLECULAR & CELLULAR PROTEOMICS

Is bone quality associated with collagen age?

(2009) D. J. Leeming et al.   OSTEOPOROSIS INTERNATIONAL

Characteristics, Formation, and Pathophysiology of Glucosepane: A Major Protein Cross-Link

(2009) Johan Svantesson Sjöberg et al.   REJUVENATION RESEARCH

Antibody against mutated citrullinated vimentin: a new sensitive marker in the diagnosis of rheumatoid arthritis

(2009) Ernst Wagner et al.   RHEUMATOLOGY INTERNATIONAL

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

What can naturally occurring mutations tell us about the pathogenesis of COPD?

(2009) S J Marciniak et al.   THORAX

Mitochondrial generation of free radicals and hypoxic signaling

(2009) Robert O. Poyton et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The matricellular functions of small leucine-rich proteoglycans (SLRPs)

(2009) Rosetta Merline et al.   Journal of Cell Communication and Signaling

Identification of Transforming Growth Factor β1–Driven Genetic Programs of Acute Lung Fibrosis

(2008) Anne-Marie Pulichino et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications

(2008) R. J. Collighan et al.   AMINO ACIDS

Characterization of metalloprotease cleavage products of human articular cartilage

(2008) Eugene Y. Zhen et al.   ARTHRITIS AND RHEUMATISM

Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease?

(2008) Helen R. Griffiths   AUTOIMMUNITY REVIEWS

Autoimmunity and oxidatively modified autoantigens

(2008) Biji T. Kurien et al.   AUTOIMMUNITY REVIEWS

Liver fibrosis

(2008) Karen Wallace et al.   BIOCHEMICAL JOURNAL

Chemical mechanisms of histone lysine and arginine modifications

(2008) Brian C. Smith et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Does increased local bone resorption secondary to breast and prostate cancer result in increased cartilage degradation?

(2008) Diana J Leeming et al.   BMC CANCER

Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation

(2008) X. Bi et al.   CARCINOGENESIS

The Potential Functional Interaction of Biglycan and WISP-1 in Controlling Differentiation and Proliferation of Osteogenic Cells

(2008) Colette A. Inkson et al.   CELLS TISSUES ORGANS

The Role of Bone Marrow-Derived Cells in Fibrosis

(2008) Wey-Ran Lin et al.   CELLS TISSUES ORGANS

Three-dimensional context regulation of metastasis

(2008) Janine T. Erler et al.   CLINICAL & EXPERIMENTAL METASTASIS

Cellular Sources of Extracellular Matrix in Hepatic Fibrosis

(2008) Rebecca G. Wells   Clinics in Liver Disease

Decorin-Mediated Inhibition of Proliferation and Migration of the Human Trophoblast via Different Tyrosine Kinase Receptors

(2008) D. Iacob et al.   ENDOCRINOLOGY

Desmosine as a biomarker of elastin degradation in COPD: current status and future directions

(2008) M. Luisetti et al.   EUROPEAN RESPIRATORY JOURNAL

Mutation analysis and characterization of COL7A1 mutations in dystrophic epidermolysis bullosa

(2008) Ningning Dang et al.   EXPERIMENTAL DERMATOLOGY

Diagnosis, management, and treatment of hepatitis C: An update

(2008) Marc G. Ghany et al.   HEPATOLOGY

Neutrophil Elastase Cleaves Laminin-332 (Laminin-5) Generating Peptides That Are Chemotactic for Neutrophils

(2008) Piotr Mydel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decorin Regulates Endothelial Cell Motility on Collagen I through Activation of Insulin-like Growth Factor I Receptor and Modulation of α2β1 Integrin Activity

(2008) Lorna R. Fiedler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dermatan sulfate proteoglycan biglycan as a potential selectin L/CD44 ligand involved in selective recruitment of peripheral blood CD16(−) natural killer cells into human endometrium

(2008) Kotaro Kitaya et al.   JOURNAL OF LEUKOCYTE BIOLOGY

In vitro degradation of human tropoelastin by MMP-12 and the generation of matrikines from domain 24

(2008) Samuel Taddese et al.   MATRIX BIOLOGY

Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation

(2008) Andreas P. Sjöberg et al.   MOLECULAR IMMUNOLOGY

The cancer biomarker problem

(2008) Charles L. Sawyers   NATURE

Mining the plasma proteome for cancer biomarkers

(2008) Samir M. Hanash et al.   NATURE

PIIANP and HELIXII diurnal variation

(2008) D.J. Quintana et al.   OSTEOARTHRITIS AND CARTILAGE

Should subchondral bone turnover be targeted when treating osteoarthritis?

(2008) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21 months by MRI

(2008) E.B. Dam et al.   OSTEOARTHRITIS AND CARTILAGE

The effects of oral calcitonin on bone collagen maturation: implications for bone turnover and quality

(2008) M. A. Karsdal et al.   OSTEOPOROSIS INTERNATIONAL

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS

Can cancer be reversed by engineering the tumor microenvironment?

(2008) Donald E. Ingber   SEMINARS IN CANCER BIOLOGY

Hepatic fibrosis—Overview

(2008) Scott L. Friedman   TOXICOLOGY

Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity

(2008) Morten A Karsdal et al.   ARTHRITIS RESEARCH & THERAPY

Fragments of extracellular matrix as mediators of inflammation

(2007) T ADAIRKIRK et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Serum Pentosidine Levels Are Positively Associated with the Presence of Vertebral Fractures in Postmenopausal Women with Type 2 Diabetes

(2007) Masahiro Yamamoto et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY