Autophagy in neuronal cells: general principles and physiological and pathological functions

Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium

(2014) Francesco Fornai et al.   Autophagy

Parkin-mediated K63-linked polyubiquitination: A signal for targeting misfolded proteins to the aggresome-autophagy pathway

(2014) James A. Olzmann et al.   Autophagy

Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis

(2014) Melissa Nassif et al.   Autophagy

A systems biology investigation of neurodegenerative dementia reveals a pivotal role of autophagy

(2014) Laura Caberlotto et al.   BMC Systems Biology

Transcriptional Regulation by Pho23 Modulates the Frequency of Autophagosome Formation

(2014) Meiyan Jin et al.   CURRENT BIOLOGY

The protein-vesicle network of autophagy

(2014) Liang Ge et al.   CURRENT OPINION IN CELL BIOLOGY

LC3 Binding to the Scaffolding Protein JIP1 Regulates Processive Dynein-Driven Transport of Autophagosomes

(2014) Meng-meng Fu et al.   DEVELOPMENTAL CELL

Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1

(2014) Alessia Di Nardo et al.   HUMAN MOLECULAR GENETICS

Mitophagy mechanisms and role in human diseases

(2014) Matthew Redmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

2-Hydroxypropyl-β-cyclodextrin Promotes Transcription Factor EB-mediated Activation of Autophagy

(2014) Wensi Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Phytoestrogen Genistein Modulates Lysosomal Metabolism and Transcription Factor EB (TFEB) Activation

(2014) Marta Moskot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolism and mis-metabolism of the neuropathological signature protein TDP-43

(2014) C.-C. Huang et al.   JOURNAL OF CELL SCIENCE

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species

(2014) E. L. Scotter et al.   JOURNAL OF CELL SCIENCE

Phosphorylation-Regulated Degradation of the Tumor-Suppressor Form of PED by Chaperone-Mediated Autophagy in Lung Cancer Cells

(2014) Cristina Quintavalle et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Cluster of Thin Tubular Structures Mediates Transformation of the Endoplasmic Reticulum to Autophagic Isolation Membrane

(2014) T. Uemura et al.   MOLECULAR AND CELLULAR BIOLOGY

Hexokinase-II Positively Regulates Glucose Starvation-Induced Autophagy through TORC1 Inhibition

(2014) David J. Roberts et al.   MOLECULAR CELL

Early Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 Kinase

(2014) Daniel Papinski et al.   MOLECULAR CELL

Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

(2014) Vladimir Rogov et al.   MOLECULAR CELL

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

Parkin-mediated ubiquitination of mutant glucocerebrosidase leads to competition with its substrates PARIS and ARTS

(2014) Inna Bendikov-Bar et al.   Orphanet Journal of Rare Diseases

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

Modulation of Mitochondrial Function and Autophagy Mediates Carnosine Neuroprotection Against Ischemic Brain Damage

(2014) Seung-Hoon Baek et al.   STROKE

Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells

(2014) Dorothea Maetzel et al.   Stem Cell Reports

VMA21 deficiency prevents vacuolar ATPase assembly and causes autophagic vacuolar myopathy

(2013) Nivetha Ramachandran et al.   ACTA NEUROPATHOLOGICA

Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration

(2013) Christiane Richter-Landsberg et al.   ACTA NEUROPATHOLOGICA

Autophagy in ageing and ageing-associated diseases

(2013) Li-qiang He et al.   ACTA PHARMACOLOGICA SINICA

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitophagy and neurodegeneration

(2013) Kim Wager et al.   Autophagy

After the banquet

(2013) Jianhui Zhu et al.   Autophagy

Characteristics and requirements of basal autophagy in HEK 293 cells

(2013) Patience Musiwaro et al.   Autophagy

RRAG GTPases link nutrient availability to gene expression, autophagy and lysosomal biogenesis

(2013) Jose A. Martina et al.   Autophagy

Autophagy

(2013) Amber N. Hale et al.   Autophagy

FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice

(2013) Takehiro Nakagaki et al.   Autophagy

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons

(2013) Karen Castillo et al.   Autophagy

Substrate recognition in selective autophagy and the ubiquitin–proteasome system

(2013) Anne Schreiber et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial quality control in neurodegenerative diseases

(2013) Luc Dupuis   BIOCHIMIE

RNA dysfunction and aggrephagy at the centre of an amyotrophic lateral sclerosis/frontotemporal dementia disease continuum

(2013) Matthew Thomas et al.   BRAIN

Unravelling mitochondrial pathways to Parkinson's disease

(2013) I Celardo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function

(2013) J. Ross Buchan et al.   CELL

Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status

(2013) Su Melser et al.   Cell Metabolism

A current perspective of autophagosome biogenesis

(2013) Shusaku T Shibutani et al.   CELL RESEARCH

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease

(2013) Carmine Spampanato et al.   EMBO Molecular Medicine

Autophagy and ageing: implications for age-related neurodegenerative diseases

(2013) Bernadette Carroll et al.   Essays in Biochemistry

Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies

(2013) Claudia Manzoni et al.   FASEB JOURNAL

Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion

(2013) Patrick Ejlerskov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Route to destruction: Autophagosomes SNARE lysosomes

(2013) Helmut Krämer   JOURNAL OF CELL BIOLOGY

Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes

(2013) Jose A. Martina et al.   JOURNAL OF CELL BIOLOGY

The role of membrane-trafficking small GTPases in the regulation of autophagy

(2013) C. F. Bento et al.   JOURNAL OF CELL SCIENCE

Autophagy and Viruses: Adversaries or Allies?

(2013) Xiaonan Dong et al.   Journal of Innate Immunity

Lysosomal Membrane Permeability Stimulates Protein Aggregate Formation in Neurons of a Lysosomal Disease

(2013) M. C. Micsenyi et al.   JOURNAL OF NEUROSCIENCE

How Positive-Strand RNA Viruses Benefit from Autophagosome Maturation

(2013) A. L. Richards et al.   JOURNAL OF VIROLOGY

Autophagy Negatively Regulates Early Axon Growth in Cortical Neurons

(2013) B.-K. Ban et al.   MOLECULAR AND CELLULAR BIOLOGY

ER exit sites are physical and functional core autophagosome biogenesis components

(2013) Martin Graef et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

(2013) Michalis Papadakis et al.   NATURE MEDICINE

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

Expression of Ambra1 in mouse brain during physiological and Alzheimer type aging

(2013) Sara Sepe et al.   NEUROBIOLOGY OF AGING

Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies

(2013) S. Pablo Sardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The EM structure of the TRAPPIII complex leads to the identification of a requirement for COPII vesicles on the macroautophagy pathway

(2013) D. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The beginning of the end: how scaffolds nucleate autophagosome biogenesis

(2013) Robin E. Stanley et al.   TRENDS IN CELL BIOLOGY

Autophagy in axonal and dendritic degeneration

(2013) Yi Yang et al.   TRENDS IN NEUROSCIENCES

Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection

(2013) Jean-François Trempe et al.   Frontiers in Neurology

Neuronal Autophagy and Neurodevelopmental Disorders

(2013) Kyung-Min Lee et al.   Experimental Neurobiology

Macroautophagy can press a brake on presynaptic neurotransmission

(2012) Ciara A. Torres et al.   Autophagy

ER stress inhibits neuronal death by promoting autophagy

(2012) Antoine Fouillet et al.   Autophagy

Exercise induces autophagy in peripheral tissues and in the brain

(2012) Congcong He et al.   Autophagy

Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells

(2012) Patricia Vázquez et al.   Autophagy

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Axonal damage, autophagy and neuronal survival

(2012) Natalia Rodríguez-Muela et al.   Autophagy

Lysosomal dysfunction causes neurodegeneration in mucolipidosis II ‘knock-in’ mice

(2012) K. Kollmann et al.   BRAIN

A Neuron-Specific Role for Autophagy in Antiviral Defense against Herpes Simplex Virus

(2012) Brian Yordy et al.   Cell Host & Microbe

Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation

(2012) Bérengère Coupé et al.   Cell Metabolism

Excessive Autophagy Contributes to Neuron Death in Cerebral Ischemia

(2012) Ruoyang Shi et al.   CNS Neuroscience & Therapeutics

A Double-Edged Sword with Therapeutic Potential: An Updated Role of Autophagy in Ischemic Cerebral Injury

(2012) Kai Wei et al.   CNS Neuroscience & Therapeutics

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response

(2012) Wenying Quan et al.   ENDOCRINOLOGY

mTOR dysfunction contributes to vacuolar pathology and weakness in valosin-containing protein associated inclusion body myopathy

(2012) J. K. Ching et al.   HUMAN MOLECULAR GENETICS

Autophagy and selective deployment of Atg proteins in antiviral defense

(2012) B. Yordy et al.   INTERNATIONAL IMMUNOLOGY

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

(2012) Andrea Longatti et al.   JOURNAL OF CELL BIOLOGY

Lysosomal storage disorders: The cellular impact of lysosomal dysfunction

(2012) Frances M. Platt et al.   JOURNAL OF CELL BIOLOGY

AP1 is essential for generation of autophagosomes from the trans-Golgi network

(2012) Y. Guo et al.   JOURNAL OF CELL SCIENCE

Rapamycin Delays Disease Onset and Prevents PrP Plaque Deposition in a Mouse Model of Gerstmann-Straussler-Scheinker Disease

(2012) C. J. Cortes et al.   JOURNAL OF NEUROSCIENCE

Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy

(2012) I. Ahmed et al.   JOURNAL OF NEUROSCIENCE

Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of  -Synuclein and LRRK2 in the Brain

(2012) L. G. Friedman et al.   JOURNAL OF NEUROSCIENCE

p62/sequestosome 1 binds to TDP-43 in brains with frontotemporal lobar degeneration with TDP-43 inclusions

(2012) Kunikazu Tanji et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Identification of Autophagosome-associated Proteins and Regulators by Quantitative Proteomic Analysis and Genetic Screens

(2012) Jörn Dengjel et al.   MOLECULAR & CELLULAR PROTEOMICS

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity

(2012) Jae-Kyo Jeong et al.   NEUROBIOLOGY OF AGING

Hypoxic stress activates chaperone-mediated autophagy and modulates neuronal cell survival

(2012) Eisuke Dohi et al.   NEUROCHEMISTRY INTERNATIONAL

SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

(2012) E. Rubino et al.   NEUROLOGY

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

Disruption of the Autophagy-Lysosome Pathway Is Involved in Neuropathology of the nclf Mouse Model of Neuronal Ceroid Lipofuscinosis

(2012) Melanie Thelen et al.   PLoS One

The E3-Ubiquitin Ligase TRIM50 Interacts with HDAC6 and p62, and Promotes the Sequestration and Clearance of Ubiquitinated Proteins into the Aggresome

(2012) Carmela Fusco et al.   PLoS One

Inhibitory effect of dietary lipids on chaperone-mediated autophagy

(2012) J. A. Rodriguez-Navarro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration

(2012) B. Dehay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

(2012) I.-F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

HDAC6 at the Intersection of Neuroprotection and Neurodegeneration

(2012) Constantin d'Ydewalle et al.   TRAFFIC

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Early otic development depends on autophagy for apoptotic cell clearance and neural differentiation

(2012) M R Aburto et al.   Cell Death & Disease

Neuronal autophagy in cerebral ischemia

(2012) Feng Xu et al.   Neuroscience Bulletin

Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing

(2011) Valerie Cullen et al.   ANNALS OF NEUROLOGY

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects

(2011) Bryan J. Bartlett et al.   Autophagy

Seeing is believing: The impact of electron microscopy on autophagy research

(2011) Eeva-Liisa Eskelinen et al.   Autophagy

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease

(2011) D A T Nijholt et al.   CELL DEATH AND DIFFERENTIATION

Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice

(2011) N Rodríguez-Muela et al.   CELL DEATH AND DIFFERENTIATION

Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation

(2011) Christelle En Lin Chua et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance

(2011) Diego L. Medina et al.   DEVELOPMENTAL CELL

Microtubule and kinesin/dynein-dependent, bi-directional transport of autolysosomes in neurites of PC12 cells

(2011) Yi Yang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Lysosomal Proteolysis Inhibition Selectively Disrupts Axonal Transport of Degradative Organelles and Causes an Alzheimer's-Like Axonal Dystrophy

(2011) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Parkin Interacts with Ambra1 to Induce Mitophagy

(2011) C. Van Humbeeck et al.   JOURNAL OF NEUROSCIENCE

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

(2011) Lei Lv et al.   MOLECULAR CELL

UBQLN2/P62 cellular recycling pathways in amyotrophic lateral sclerosis and frontotemporal dementia

(2011) Faisal Fecto et al.   MUSCLE & NERVE

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

(2011) Han-Xiang Deng et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

(2011) Mali Jiang et al.   NATURE MEDICINE

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

(2011) P. Wild et al.   SCIENCE

Autophagy in the control and pathogenesis of viral infection

(2011) Brian Yordy et al.   Current Opinion in Virology

Dynein- and activity-dependent retrograde transport of autophagosomes in neuronal axons

(2010) Kiyoshi Katsumata et al.   Autophagy

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

Short-term fasting induces profound neuronal autophagy

(2010) Mehrdad Alirezaei et al.   Autophagy

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

(2010) Emilie Tresse et al.   Autophagy

Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

(2010) Yoshinori Takahashi et al.   Autophagy

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Autophagy Protects against Sindbis Virus Infection of the Central Nervous System

(2010) Anthony Orvedahl et al.   Cell Host & Microbe

DAP1, a Novel Substrate of mTOR, Negatively Regulates Autophagy

(2010) Itay Koren et al.   CURRENT BIOLOGY

Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders

(2010) Alessandro Fraldi et al.   EMBO JOURNAL

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

Fighting disease by selective autophagy of aggregate-prone proteins

(2010) Helene Knaevelsrud et al.   FEBS LETTERS

Parkin-mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network

(2010) Atsushi Tanaka   FEBS LETTERS

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

(2010) C. Rothenberg et al.   HUMAN MOLECULAR GENETICS

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L

(2010) Kohichi Matsunaga et al.   JOURNAL OF CELL BIOLOGY

Regulation of TDP-43 aggregation by phosphorylation andp62/SQSTM1

(2010) Owen A. Brady et al.   JOURNAL OF NEUROCHEMISTRY

Exit from the Golgi Is Required for the Expansion of the Autophagosomal Phagophore in Yeast Saccharomyces cerevisiae

(2010) Aniek van der Vaart et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of Regulators of Chaperone-Mediated Autophagy

(2010) Urmi Bandyopadhyay et al.   MOLECULAR CELL

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Analysis of optineurin in frontotemporal lobar degeneration

(2010) Sara Rollinson et al.   NEUROBIOLOGY OF AGING

Macroautophagy is defective in mucolipin-1-deficient mouse neurons

(2010) Cyntia Curcio-Morelli et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging

(2010) Yakup Batlevi et al.   NEUROBIOLOGY OF DISEASE

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

IGF-I stimulates Rab7-RILP interaction during neuronal autophagy

(2010) Mona Bains et al.   NEUROSCIENCE LETTERS

Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)

(2010) Laura E. Cox et al.   PLoS One

Loss of ALS2/Alsin Exacerbates Motor Dysfunction in a SOD1H46R-Expressing Mouse ALS Model by Disturbing Endolysosomal Trafficking

(2010) Shinji Hadano et al.   PLoS One

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of acute axonal degeneration in the optic nerve in vivo

(2010) J. Knoferle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chaperone-mediated autophagy: Molecular mechanisms and physiological relevance

(2010) Samantha J. Orenstein et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Autophagy induction by trehalose counter-acts cellular prion-infection

(2009) Yasmine Aguib et al.   Autophagy

3D tomography reveals connections between the phagophore and endoplasmic reticulum

(2009) Päivi Ylä-Anttila et al.   Autophagy

Hypoxia-induced autophagy: cell death or cell survival?

(2009) Nathalie M Mazure et al.   CURRENT OPINION IN CELL BIOLOGY

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

VCPMutations Causing Frontotemporal Lobar Degeneration Disrupt Localization of TDP-43 and Induce Cell Death

(2009) Michael A. Gitcho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neural-specific Deletion of FIP200 Leads to Cerebellar Degeneration Caused by Increased Neuronal Death and Axon Degeneration

(2009) Chun-Chi Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

(2009) Jeong-Sun Ju et al.   JOURNAL OF CELL BIOLOGY

Chaperone-mediated autophagy is defective in mucolipidosis type IV

(2009) Bhuvarahamurthy Venugopal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism

(2009) Jozsef Gal et al.   JOURNAL OF NEUROCHEMISTRY

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

(2009) Andreas Heiseke et al.   JOURNAL OF NEUROCHEMISTRY

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

Hydrogen peroxide induces autophagic cell death in C6 glioma cells via BNIP3-mediated suppression of the mTOR pathway

(2009) Yu Jeong Byun et al.   NEUROSCIENCE LETTERS

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy

(2009) Q. Yang et al.   SCIENCE

Oxidative Stress Induces Parallel Autophagy and Mitochondria Dysfunction in Human Glioma U251 Cells

(2009) Hongyu Zhang et al.   TOXICOLOGICAL SCIENCES

Autophagy: A lysosomal degradation pathway with a central role in health and disease

(2008) Eeva-Liisa Eskelinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Secondary lipid accumulation in lysosomal disease

(2008) Steven U. Walkley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lysosomal disorders: From storage to cellular damage

(2008) Andrea Ballabio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quality control of mitochondria: protection against neurodegeneration and ageing

(2008) Takashi Tatsuta et al.   EMBO JOURNAL

Autophagic dysfunction in mucolipidosis type IV patients

(2008) Silvia Vergarajauregui et al.   HUMAN MOLECULAR GENETICS

Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy

(2008) Tomohiro Kabuta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase Cθ Is Required for Autophagy in Response to Stress in the Endoplasmic Reticulum

(2008) Kenjiro Sakaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease

(2008) David Sulzer et al.   JOURNAL OF NEUROCHEMISTRY

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

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