A Double-Edged Sword with Therapeutic Potential: An Updated Role of Autophagy in Ischemic Cerebral Injury

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

(2014) Daniel J. Klionsky et al.   Autophagy

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

(2014) Ya-Dan Wen et al.   Autophagy

Autophagic neuron death in neonatal brain ischemia/hypoxia

(2014) Yasuo Uchiyama et al.   Autophagy

Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy

(2014) You-Tong Wu et al.   Autophagy

2-Methoxyestradiol Attenuates Autophagy Activation After Global Ischemia

(2014) Xiao-Yu Xin et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

(2012) Pei Wang et al.   Autophagy

Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning

(2012) Rui Sheng et al.   Autophagy

Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemia

(2012) Suresh L Mehta et al.   BMC NEUROSCIENCE

Beta-asarone attenuates ischemia–reperfusion-induced autophagy in rat brains via modulating JNK, p-JNK, Bcl-2 and Beclin 1

(2012) Lin Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Autophagy in hypoxia-ischemia induced brain injury

(2012) Walter Balduini et al.   Journal of Maternal-Fetal & Neonatal Medicine

Tetrahydrocurcumin Ameliorates Homocysteinylated Cytochrome-c Mediated Autophagy in Hyperhomocysteinemia Mice after Cerebral Ischemia

(2012) Neetu Tyagi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

NAD+ administration decreases ischemic brain damage partially by blocking autophagy in a mouse model of brain ischemia

(2012) Chaobo Zheng et al.   NEUROSCIENCE LETTERS

Propofol Prevents Autophagic Cell Death following Oxygen and Glucose Deprivation in PC12 Cells and Cerebral Ischemia-Reperfusion Injury in Rats

(2012) Derong Cui et al.   PLoS One

Death and survival of neuronal and astrocytic cells in ischemic brain injury: a role of autophagy

(2011) Min Xu et al.   ACTA PHARMACOLOGICA SINICA

Beclin 1 or not Beclin 1...

(2011) Tassula Proikas-Cezanne et al.   Autophagy

Autophagy controls plant basal immunity in a pathogenic lifestyle-dependent manner

(2011) Heike D. Lenz et al.   Autophagy

The unfolded protein response and proteostasis in Alzheimer disease

(2011) Wiep Scheper et al.   Autophagy

Acute induction of autophagy as a novel strategy for cardioprotection

(2011) Karin Przyklenk et al.   Autophagy

Metabolic regulation by HMGB1-mediated autophagy and mitophagy

(2011) Rui Kang et al.   Autophagy

AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation

(2011) Libin Shang et al.   Autophagy

Accumulation of p62 in degenerated spinal cord under chronic mechanical compression

(2011) Fumito Tanabe et al.   Autophagy

Autophagy and Akt promote survival in glioma

(2011) Qi-Wen Fan et al.   Autophagy

eEF-2 kinase, another meddler in the “Yin and Yang” of Akt–mediated cell fate?

(2011) Yan Cheng et al.   Autophagy

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects

(2011) Bryan J. Bartlett et al.   Autophagy

The protective role of autophagy against aging and acute ischemic injury in kidney proximal tubular cells

(2011) Yoshitaka Isaka et al.   Autophagy

Chasing the elusive mammalian microautophagy

(2011) Laura Santambrogio et al.   Autophagy

Therapy mediated by mitophagy abrogates tumor progression

(2011) Ricardo Gargini et al.   Autophagy

Beclin 1-independent autophagy contributes to apoptosis in cortical neurons

(2011) Yulia Grishchuk et al.   Autophagy

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation

(2011) Chang Hwa Jung et al.   Autophagy

AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy

(2011) Zhonglin Xie et al.   Autophagy

Autophagy stimulation by rapamycin suppresses lung inflammation and infection byBurkholderia cenocepaciain a model of cystic fibrosis

(2011) Basant A. Abdulrahman et al.   Autophagy

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Seeing is believing: The impact of electron microscopy on autophagy research

(2011) Eeva-Liisa Eskelinen et al.   Autophagy

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

(2011) Elaine A. Dunlop et al.   Autophagy

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

(2011) Antje S. Löffler et al.   Autophagy

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

GSK-3β inhibitors suppressed neuroinflammation in rat cortex by activating autophagy in ischemic brain injury

(2011) Xiaogang Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intranasal Ginsenoside Rb1 Targets the Brain and Ameliorates Cerebral Ischemia/Reperfusion Injury in Rats

(2011) Tingting Lu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice

(2011) Ning Liu et al.   BRAIN RESEARCH

Autophagy activation is involved in neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats

(2011) Wenjun Yan et al.   BRAIN RESEARCH

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Cell death pathways and autophagy in the central nervous system and its involvement in neurodegeneration, immunity and central nervous system infection: to die or not to die - that is the question

(2011) A. Rosello et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Toward a Unifying Hypothesis in the Development of Alzheimer's Disease

(2011) Brian Balin et al.   CNS Neuroscience & Therapeutics

AMPK and autophagy get connected

(2011) D Grahame Hardie   EMBO JOURNAL

Transmembrane protein 166 regulates autophagic and apoptotic activities following focal cerebral ischemic injury in rats

(2011) Li Li et al.   EXPERIMENTAL NEUROLOGY

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Severe Global Cerebral Ischemia-Induced Programmed Necrosis of Hippocampal CA1 Neurons in Rat Is Prevented by 3-Methyladenine: A Widely Used Inhibitor of Autophagy

(2011) Jin-Ye Wang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Amlodipine and atorvastatin exert protective and additive effects via antiapoptotic and antiautophagic mechanisms after transient middle cerebral artery occlusion in Zucker metabolic syndrome rats

(2011) Xuemei Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Control of autophagy as a therapy for neurodegenerative disease

(2011) Harry Harris et al.   Nature Reviews Neurology

3-n-butylphthalide (NBP) attenuated neuronal autophagy and amyloid-beta expression in diabetic mice subjected to brain ischemia

(2011) Ting Zhang et al.   NEUROLOGICAL RESEARCH

Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging

(2011) D. R. Green et al.   SCIENCE

Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia

(2010) Ai-Ping Qin et al.   Autophagy

Autophagy is induced by ischemic preconditioning in human livers formerly treated by chemotherapy to limit necrosis

(2010) Davide Degli Esposti et al.   Autophagy

Broadening the therapeutic scope for rapamycin treatment

(2010) Fiona M. Menzies et al.   Autophagy

Nonredundant role of Atg7 in mitochondrial clearance during erythroid development

(2010) Monika Mortensen et al.   Autophagy

A defect in cytosolic carboxypeptidase 1 (Nna1) causes autophagy inPurkinje cell degenerationmouse brain

(2010) Iryna Berezniuk et al.   Autophagy

Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer

(2010) Kevin Dalby et al.   Autophagy

A reporter cell system to monitor autophagy based on p62/SQSTM1

(2010) Kenneth Bowitz Larsen et al.   Autophagy

Synergy and antagonism of macroautophagy and chaperone-mediated autophagy in a cell model of pathological tau aggregation

(2010) Yipeng Wang et al.   Autophagy

Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia

(2010) Silvia Carloni et al.   Autophagy

TheArabidopsis thalianaACBP3 regulates leaf senescence by modulating phospholipid metabolism and ATG8 stability

(2010) Shi Xiao et al.   Autophagy

ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy

(2010) Michael Dewaele et al.   Autophagy

Autophagy in ALDH2-elicited cardioprotection against ischemic heart disease: Slayer or savior?

(2010) Yingmei Zhang et al.   Autophagy

Autophagy and adipogenesis: Implications in obesity and type II diabetes

(2010) Scott Goldman et al.   Autophagy

Autophagy

(2010) Lijun Zhou et al.   Autophagy

In vivo imaging of autophagy in a mouse stroke model

(2010) FengFeng Tian et al.   Autophagy

Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning

(2010) Rui Sheng et al.   Autophagy

ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy

(2010) Liang Qin et al.   Autophagy

Lysosomal membrane permeabilization in Parkinson disease

(2010) Miquel Vila et al.   Autophagy

The double-edged effect of autophagy in pancreatic beta cells and diabetes

(2010) Ze-fang Chen et al.   Autophagy

The emerging role of autophagy in the pathophysiology of diabetes mellitus

(2010) Claudio D. Gonzalez et al.   Autophagy

Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation: Figure 1

(2010) Annakaisa Haapasalo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Hyperbaric oxygen preconditioning reduces ischemia–reperfusion injury by stimulating autophagy in neurocyte

(2010) Yong-Chun Wang et al.   BRAIN RESEARCH

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Targeting Histone Deacetylases for the Treatment of Huntington's Disease

(2010) Steven G. Gray   CNS Neuroscience & Therapeutics

The Role of Tau in Alzheimer's Disease and Related Disorders

(2010) Rodrigo Medeiros et al.   CNS Neuroscience & Therapeutics

Physiological significance of selective degradation of p62 by autophagy

(2010) Masaaki Komatsu et al.   FEBS LETTERS

Melatonin protects N2a against ischemia/reperfusion injury through autophagy enhancement

(2010) Yanchun Guo et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Autophagy and protein aggregation after brain ischemia

(2010) Chunli Liu et al.   JOURNAL OF NEUROCHEMISTRY

Antiapoptotic and antiautophagic effects of glial cell line-derived neurotrophic factor and hepatocyte growth factor after transient middle cerebral artery occlusion in rats

(2010) Jingwei Shang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

RETRACTED: The Skp2 Promoter Integrates Signaling through the NF-κB, p53, and Akt/GSK3β Pathways to Regulate Autophagy and Apoptosis

(2010) Benjamin Barré et al.   MOLECULAR CELL

Unknown

(2010) Anita Ost et al.   MOLECULAR MEDICINE

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

(2010) Alessandro Luciani et al.   NATURE CELL BIOLOGY

Autophagy in acute brain injury: Feast, famine, or folly?

(2010) Craig M. Smith et al.   NEUROBIOLOGY OF DISEASE

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Exacerbation of ischemia-induced amyloid-β generation by diabetes is associated with autophagy activation in mice brain

(2010) Ting Zhang et al.   NEUROSCIENCE LETTERS

Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1

(2010) M Djavaheri-Mergny et al.   ONCOGENE

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

(2010) Q.-W. Fan et al.   Science Signaling

Lithium reduces apoptosis and autophagy after neonatal hypoxia–ischemia

(2010) Q Li et al.   Cell Death & Disease

Autophagy Induced by Ischemic Preconditioning is Essential for Cardioprotection

(2010) Chengqun Huang et al.   Journal of Cardiovascular Translational Research

Manganese Superoxide Dismutase Deficiency Exacerbates Ischemic Brain Damage Under Hyperglycemic Conditions by Altering Autophagy

(2010) Suresh L. Mehta et al.   Translational Stroke Research

RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats

(2009) Yong-qiu Zheng et al.   ACTA PHARMACOLOGICA SINICA

Enhancement of Autophagic Flux after Neonatal Cerebral Hypoxia-Ischemia and Its Region-Specific Relationship to Apoptotic Mechanisms

(2009) Vanessa Ginet et al.   AMERICAN JOURNAL OF PATHOLOGY

Potential role of autophagy in modulation of lipid metabolism

(2009) Julia Kovsan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Postischemic treatment of neonatal cerebral ischemia should target autophagy

(2009) Julien Puyal et al.   ANNALS OF NEUROLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Autophagy Suppresses Tumorigenesis through Elimination of p62

(2009) Robin Mathew et al.   CELL

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes

(2009) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Autophagy, Immunity, and Microbial Adaptations

(2009) Vojo Deretic et al.   Cell Host & Microbe

Autophagy for the avoidance of neurodegeneration

(2009) F. Madeo et al.   GENES & DEVELOPMENT

Constitutive Reactive Oxygen Species Generation from Autophagosome/Lysosome in Neuronal Oxidative Toxicity

(2009) Chisato Kubota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxic preconditioning reinforces HIF-alpha-dependent HSP70 signaling to reduce ischemic renal failure-induced renal tubular apoptosis and autophagy

(2009) Chung-Hsin Yeh et al.   LIFE SCIENCES

All-you-can-eat: autophagy in neurodegeneration and neuroprotection

(2009) Philipp A Jaeger et al.   Molecular Neurodegeneration

Autophagy genes in immunity

(2009) Herbert W Virgin et al.   NATURE IMMUNOLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hyperbaric oxygen therapy and cerebral ischemia: neuroprotective mechanisms

(2009) Gerald A. Matchett et al.   NEUROLOGICAL RESEARCH

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

Eaten Alive

(2008) Charleen T. Chu   AMERICAN JOURNAL OF PATHOLOGY

Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury

(2008) Masato Koike et al.   AMERICAN JOURNAL OF PATHOLOGY

Review of Tissue Plasminogen Activator, Ischemic Stroke, and Potential Legal Issues

(2008) Bryan A. Liang et al.   ARCHIVES OF NEUROLOGY

The life of a cell: apoptosis regulation by the PI3K/PKB pathway

(2008) Vincent Duronio   BIOCHEMICAL JOURNAL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Warts Is Required for PI3K-Regulated Growth Arrest, Autophagy, and Autophagic Cell Death in Drosophila

(2008) Sudeshna Dutta et al.   CURRENT BIOLOGY

PI3K signaling of autophagy is required for starvation tolerance and virulenceof Cryptococcus neoformans

(2008) Guowu Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

Stroke

(2008) Geoffrey A Donnan et al.   LANCET

Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury

(2008) Silvia Carloni et al.   NEUROBIOLOGY OF DISEASE

Autophagy is involved in the ischemic preconditioning

(2008) Hee-Kwon Park et al.   NEUROSCIENCE LETTERS

Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic

(2008) Manuel Yepes et al.   TRENDS IN NEUROSCIENCES

Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death

(2007) A. Rami et al.   NEUROBIOLOGY OF DISEASE