期刊
NEUROBIOLOGY OF AGING
卷 33, 期 2, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2010.10.002
关键词
Frontotemporal lobar degeneration; FTLD; optineurin
资金
- Medical Research Council [G0701441] Funding Source: Medline
- Wellcome Trust [089701] Funding Source: Medline
- Medical Research Council [G0701441] Funding Source: researchfish
- MRC [G0701441] Funding Source: UKRI
Frontotemporal lobar degeneration (FTLD) can occur jointly with amyotrophic lateral sclerosis (ALS), and these 2 conditions share a genetic risk factor on chromosome 9. It has been reported that mutations in optineurin (OPTN) can cause ALS. Therefore, we sequenced OPTN in 371 FTLD cases but no mutations were detected, suggesting changes in OPTN do not cause FTLD. (C) 2012 Elsevier Inc. All rights reserved.
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