FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice

Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

(2012) Véronique Schaeffer et al.   BRAIN

Rapamycin Delays Disease Onset and Prevents PrP Plaque Deposition in a Mouse Model of Gerstmann-Straussler-Scheinker Disease

(2012) C. J. Cortes et al.   JOURNAL OF NEUROSCIENCE

Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection

(2012) D. Ishibashi et al.   JOURNAL OF VIROLOGY

Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry

(2011) Pelagia Deriziotis et al.   EMBO JOURNAL

Autophagy deregulation in neurodegenerative diseases - recent advances and future perspectives

(2011) Zelda H. Cheung et al.   JOURNAL OF NEUROCHEMISTRY

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice

(2011) Daisuke Ishibashi et al.   VACCINE

Autophagosome Formation and Molecular Mechanism of Autophagy

(2010) Isei Tanida   ANTIOXIDANTS & REDOX SIGNALING

Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain–dependent manner

(2010) Jan Kranich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Manganese chelation therapy extends survival in a mouse model of M1000 prion disease

(2010) Marcus W. Brazier et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of FK506 Binding Proteins Reduces  -Synuclein Aggregation and Parkinson's Disease-Like Pathology

(2010) M. Gerard et al.   JOURNAL OF NEUROSCIENCE

Calcineurin Inhibition at the Clinical Phase of Prion Disease Reduces Neurodegeneration, Improves Behavioral Alterations and Increases Animal Survival

(2010) Abhisek Mukherjee et al.   PLoS Pathogens

FK506 Protects Against Various Immune Responses and Secondary Degeneration Following Cerebral Ischemia

(2009) Stephan Brecht et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Autophagy induction by trehalose counter-acts cellular prion-infection

(2009) Yasmine Aguib et al.   Autophagy

Therapeutic interventions ameliorating prion disease

(2009) Marcus W Brazier et al.   Expert Review of Anti-Infective Therapy

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

(2009) Andreas Heiseke et al.   JOURNAL OF NEUROCHEMISTRY

Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial

(2009) John Collinge et al.   LANCET NEUROLOGY

Continuous intraventricular infusion of pentosan polysulfate: Clinical trial against prion diseases

(2009) Yoshio Tsuboi et al.   NEUROPATHOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology