标题
Alternative splicing isoforms in health and disease
作者
关键词
Cancer, Neurodegenerative diseases, Cardiovascular disease, Metabolic disease, Mitochondria, Splicing factor, Intron, Exon skipping
出版物
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Volume 470, Issue 7, Pages 995-1016
出版商
Springer Nature
发表日期
2018-03-14
DOI
10.1007/s00424-018-2136-x
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Global profiling of Rbm24 bound RNAs uncovers a multi-tasking RNA binding protein
- (2018) Yu Lin et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival
- (2017) Jonàs Juan-Mateu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An unexpected role for the transcriptional coactivator isoform NT-PGC-1α in the regulation of mitochondrial respiration in brown adipocytes
- (2017) Ji Suk Chang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α
- (2017) Charles B.B. Gray et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Abnormalities in alternative splicing in diabetes: therapeutic targets
- (2017) Zodwa Dlamini et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Splicing regulation and dysregulation of cholinergic genes expressed at the neuromuscular junction
- (2017) Kinji Ohno et al. JOURNAL OF NEUROCHEMISTRY
- Identification of SERINC5-001 as the Predominant Spliced Isoform for HIV-1 Restriction
- (2017) Xianfeng Zhang et al. JOURNAL OF VIROLOGY
- Alternative splicing as a regulator of development and tissue identity
- (2017) Francisco E. Baralle et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Exclusion of alternative exon 33 of CaV1.2 calcium channels in heart is proarrhythmogenic
- (2017) Guang Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Selective induction of alternatively spliced FynT isoform by TNF facilitates persistent inflammatory responses in astrocytes
- (2017) Chingli Lee et al. Scientific Reports
- The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications
- (2017) O. Escribano et al. Journal of Diabetes Research
- MITA/STING and Its Alternative Splicing Isoform MRP Restrict Hepatitis B Virus Replication
- (2017) Shuhui Liu et al. PLoS One
- Mutations in Complex I Assembly Factor TMEM126B Result in Muscle Weakness and Isolated Complex I Deficiency
- (2016) Laura Sánchez-Caballero et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Differential Response to Risperidone in Schizophrenia Patients byKCNH2Genotype and Drug Metabolizer Status
- (2016) Juliane Heide et al. AMERICAN JOURNAL OF PSYCHIATRY
- A Loss-of-Function Variant in a Minor Isoform of ANK3 Protects Against Bipolar Disorder and Schizophrenia
- (2016) Timothy Hughes et al. BIOLOGICAL PSYCHIATRY
- Faulty splicing and cytoskeleton abnormalities in Huntington's disease
- (2016) Marta Fernández-Nogales et al. BRAIN PATHOLOGY
- Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1
- (2016) Li Chen et al. CELL CYCLE
- Alternative splicing and cell survival: from tissue homeostasis to disease
- (2016) Maria Paola Paronetto et al. CELL DEATH AND DIFFERENTIATION
- Emerging Role for RBM20 and its Splicing Substrates in Cardiac Function and Heart Failure
- (2016) Jipeng Ma et al. CURRENT PHARMACEUTICAL DESIGN
- Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides
- (2016) A. J. Hinrich et al. EMBO Molecular Medicine
- Alternative splicing directs two IL-20R2 isoforms and is responsible for the incomplete gene knockout via the exon I ablation
- (2016) H Zhou et al. GENES AND IMMUNITY
- Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes
- (2016) Vicente Martínez-Redondo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- β-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization
- (2016) Seth M. Dever et al. JOURNAL OF NEUROVIROLOGY
- Functional Dissection of an Alternatively Spliced Herpesvirus Gene by Splice Site Mutagenesis
- (2016) Tim Schommartz et al. JOURNAL OF VIROLOGY
- Therapeutic targeting of splicing in cancer
- (2016) Stanley Chun-Wei Lee et al. NATURE MEDICINE
- Alternative polyadenylation of mRNA precursors
- (2016) Bin Tian et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Rbm24 Regulates Alternative Splicing Switch in Embryonic Stem Cell Cardiac Lineage Differentiation
- (2016) Tao Zhang et al. STEM CELLS
- Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy
- (2016) Fernande Freyermuth et al. Nature Communications
- Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes
- (2016) Curtis A. Nutter et al. Cell Reports
- Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival
- (2016) Pushkar Malakar et al. Scientific Reports
- Mitochondrial Reprogramming Induced by CaMKII Mediates Hypertrophy Decompensation
- (2015) B. D. Westenbrink et al. CIRCULATION RESEARCH
- Antisense Therapy for Cardiovascular Diseases
- (2015) M. Phillips et al. CURRENT PHARMACEUTICAL DESIGN
- The hitchhiker’s guide to PGC-1α isoform structure and biological functions
- (2015) Vicente Martínez-Redondo et al. DIABETOLOGIA
- Global variability in gene expression and alternative splicing is modulated by mitochondrial content
- (2015) Raul Guantes et al. GENOME RESEARCH
- The role of CaMKII in diabetic heart dysfunction
- (2015) Lorna Daniels et al. HEART FAILURE REVIEWS
- Alternatively Spliced Myeloid Differentiation Protein-2 Inhibits TLR4-Mediated Lung Inflammation
- (2015) Gantsetseg Tumurkhuu et al. JOURNAL OF IMMUNOLOGY
- Insights into alternative splicing of sarcomeric genes in the heart
- (2015) Cornelis J. Weeland et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- An isoform-specific role of FynT tyrosine kinase in Alzheimer's disease
- (2015) Chingli Lee et al. JOURNAL OF NEUROCHEMISTRY
- The spliceosome is a therapeutic vulnerability in MYC-driven cancer
- (2015) Tiffany Y.-T. Hsu et al. NATURE
- Lower expression level of two RAGE alternative splicing isoforms in Alzheimer’s disease
- (2015) Haiyan Zhu et al. NEUROSCIENCE LETTERS
- TCGASpliceSeq a compendium of alternative mRNA splicing in cancer
- (2015) Michael Ryan et al. NUCLEIC ACIDS RESEARCH
- Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
- (2015) A Sveen et al. ONCOGENE
- Exon Organization and Novel Alternative Splicing of Ank3 in Mouse Heart
- (2015) Gokay Yamankurt et al. PLoS One
- Inhibitors of CLK Protein Kinases Suppress Cell Growth and Induce Apoptosis by Modulating Pre-mRNA Splicing
- (2015) Shinsuke Araki et al. PLoS One
- Intercellular: local and systemic actions of skeletal muscle PGC-1s
- (2015) Jorge C. Correia et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Inhibition of vemurafenib-resistant melanoma by interference with pre-mRNA splicing
- (2015) Maayan Salton et al. Nature Communications
- Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure
- (2015) Chaoliang Wei et al. Cell Reports
- Functional roles of alternative splicing factors in human disease
- (2015) Benjamin Cieply et al. Wiley Interdisciplinary Reviews-RNA
- Induction of the calcineurin variant CnAβ1 after myocardial infarction reduces post-infarction ventricular remodelling by promoting infarct vascularization
- (2014) Marina M. López-Olañeta et al. CARDIOVASCULAR RESEARCH
- Antisense oligonucleotides in cancer
- (2014) Daniela Castanotto et al. CURRENT OPINION IN ONCOLOGY
- Function and Regulation of the Na+-Ca2+Exchanger NCX3 Splice Variants in Brain and Skeletal Muscle
- (2014) Lauriane Y. M. Michel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Unspliced X-box-binding Protein 1 (XBP1) Protects Endothelial Cells from Oxidative Stress through Interaction with Histone Deacetylase 3
- (2014) Daniel Martin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Exercise-induced expression of peroxisome proliferator-activated receptor γ coactivator-1α isoforms in skeletal muscle of endurance-trained males
- (2014) Daniil V. Popov et al. Journal of Physiological Sciences
- The alternative splicing of the apolipoprotein E gene is unperturbed in the brains of Alzheimer’s disease patients
- (2014) James D. Mills et al. MOLECULAR BIOLOGY REPORTS
- Nova1 is a master regulator of alternative splicing in pancreatic beta cells
- (2014) Olatz Villate et al. NUCLEIC ACIDS RESEARCH
- New insights into IGF-1 signaling in the heart
- (2014) Rodrigo Troncoso et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Alternative splicing isoform in succinate dehydrogenase complex, subunit C causes downregulation of succinate-coenzyme Q oxidoreductase activity in mitochondria
- (2014) NANA SATOH et al. Oncology Letters
- Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development
- (2014) Jimena Giudice et al. Nature Communications
- Alternative Splice Forms of CTLA-4 Induced by Antisense Mediated Splice-Switching Influences Autoimmune Diabetes Susceptibility in NOD Mice
- (2014) Dan V. Mourich et al. Nucleic Acid Therapeutics
- Involvement of Endocytosis and Alternative Splicing in the Formation of the Pathological Process in the Early Stages of Parkinson’s Disease
- (2014) Anelya Kh. Alieva et al. Biomed Research International
- Exon identity crisis: disease-causing mutations that disrupt the splicing code
- (2014) Timothy Sterne-Weiler et al. GENOME BIOLOGY
- Brugada syndrome and abnormal splicing of SCN5A in myotonic dystrophy type 1
- (2013) Karim Wahbi et al. Archives of Cardiovascular Diseases
- Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis
- (2013) Lingfang Zeng et al. CIRCULATION
- Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors
- (2013) F. A. L. M. Eskens et al. CLINICAL CANCER RESEARCH
- Alternative splicing of AMPA receptor subunits in the 6-OHDA-lesioned rat model of Parkinson's disease and L-DOPA-induced dyskinesia
- (2013) Christopher Kobylecki et al. EXPERIMENTAL NEUROLOGY
- A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors
- (2013) D. S. Hong et al. INVESTIGATIONAL NEW DRUGS
- The SLC2 (GLUT) family of membrane transporters
- (2013) Mike Mueckler et al. MOLECULAR ASPECTS OF MEDICINE
- The Alternative Heart: Impact of Alternative Splicing in Heart Disease
- (2013) Enrique Lara-Pezzi et al. Journal of Cardiovascular Translational Research
- Misregulation of Pre-mRNA Alternative Splicing in Cancer
- (2013) J. Zhang et al. Cancer Discovery
- RNA-binding protein RBM24 is required for sarcomere assembly and heart contractility
- (2012) Kar Lai Poon et al. CARDIOVASCULAR RESEARCH
- A PGC-1α Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy
- (2012) Jorge L. Ruas et al. CELL
- Natural production and functional effects of alternatively spliced interleukin-4 protein in asthma
- (2012) Irina G. Luzina et al. CYTOKINE
- NT-PGC-1α Protein Is Sufficient to Link β3-Adrenergic Receptor Activation to Transcriptional and Physiological Components of Adaptive Thermogenesis
- (2012) Ji Suk Chang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Leucine-rich repeat kinase 2 and alternative splicing in Parkinson's disease
- (2012) David A. Elliott et al. MOVEMENT DISORDERS
- Transcriptional Activity of PGC-1αand NT-PGC-1αIs Differentially Regulated by Twist-1 in Brown Fat Metabolism
- (2012) Hee-Jin Jun et al. PPAR Research
- mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart
- (2011) Manlio Vinciguerra et al. AGING CELL
- IGF-1Ea induces vessel formation after injury and mediates bone marrow and heart cross-talk through the expression of specific cytokines
- (2011) Maria Paola Santini et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Role of RBM25/LUC7L3 in Abnormal Cardiac Sodium Channel Splicing Regulation in Human Heart Failure
- (2011) Ge Gao et al. CIRCULATION
- Calcineurin Splicing Variant Calcineurin Aβ1 Improves Cardiac Function After Myocardial Infarction Without Inducing Hypertrophy
- (2011) Leanne E. Felkin et al. CIRCULATION
- Cyclic AMP-dependent Protein Kinase Regulates the Alternative Splicing of Tau Exon 10
- (2011) Jianhua Shi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Exon Arrays Reveal Alternative Splicing Aberrations in Parkinsons Disease Leukocytes
- (2011) Lilach Soreq et al. Neurodegenerative Diseases
- Skeletal Muscle-Specific Expression of PGC-1α-b, an Exercise-Responsive Isoform, Increases Exercise Capacity and Peak Oxygen Uptake
- (2011) Miki Tadaishi et al. PLoS One
- Cyclic AMP-Dependent Protein Kinase A Regulates the Alternative Splicing of CaMKIIδ
- (2011) Qingqing Gu et al. PLoS One
- Alternative splicing and disease
- (2011) Eddo Kim et al. RNA Biology
- EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy
- (2010) Roman Schoenauer et al. BASIC RESEARCH IN CARDIOLOGY
- Cytoscape 2.8: new features for data integration and network visualization
- (2010) M. E. Smoot et al. BIOINFORMATICS
- Psoriasis and extra domain A fibronectin loops
- (2010) J.P. McFadden et al. BRITISH JOURNAL OF DERMATOLOGY
- An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis
- (2010) Michael J. Moore et al. CELL
- Molecular and Functional Characterization of a Novel Cardiac-Specific Human Tropomyosin Isoform
- (2010) Sudarsan Rajan et al. CIRCULATION
- Heart Failure–Associated Changes in RNA Splicing of Sarcomere Genes
- (2010) Sek Won Kong et al. Circulation-Cardiovascular Genetics
- Identification of a Novel Human MD-2 Splice Variant That Negatively Regulates Lipopolysaccharide-Induced TLR4 Signaling
- (2010) P. Gray et al. JOURNAL OF IMMUNOLOGY
- X-box binding protein 1 regulates brain natriuretic peptide through a novel AP1/CRE-like element in cardiomyocytes
- (2010) Tamaki Sawada et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Alternative splicing and evolution: diversification, exon definition and function
- (2010) Hadas Keren et al. NATURE REVIEWS GENETICS
- Decreased alternative splicing of estrogen receptor-α mRNA in the Alzheimer's disease brain
- (2010) Tatjana A. Ishunina et al. NEUROBIOLOGY OF AGING
- 17A, a novel non-coding RNA, regulates GABA B alternative splicing and signaling in response to inflammatory stimuli and in Alzheimer disease
- (2010) Sara Massone et al. NEUROBIOLOGY OF DISEASE
- The expression of HMGA1a is increased in lymphoblastoid cell lines from schizophrenia patients
- (2010) Tomomi Morikawa et al. NEUROCHEMISTRY INTERNATIONAL
- Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation
- (2010) Gabriel A. Roybal et al. NUCLEIC ACIDS RESEARCH
- SRRM2, a Potential Blood Biomarker Revealing High Alternative Splicing in Parkinson's Disease
- (2010) Lina A. Shehadeh et al. PLoS One
- Fine Mapping of Calcineurin (PPP3CA) Gene Reveals Novel Alternative Splicing Patterns, Association of 5′UTR Trinucleotide Repeat With Addiction Vulnerability, and Differential Isoform Expression in Alzheimer's Disease
- (2010) Matthew J. Chiocco et al. SUBSTANCE USE & MISUSE
- Identification and characterization of an alternative promoter of the human PGC-1α gene
- (2009) Toyo Yoshioka et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Impaired binding of ZASP/Cypher with phosphoglucomutase 1 is associated with dilated cardiomyopathy
- (2009) T. Arimura et al. CARDIOVASCULAR RESEARCH
- Oxidants induce alternative splicing of α-synuclein: Implications for Parkinson's disease
- (2009) Shasi V. Kalivendi et al. FREE RADICAL BIOLOGY AND MEDICINE
- Alternative mRNA Splicing Produces a Novel Biologically Active Short Isoform of PGC-1α
- (2009) Yubin Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mutations in Ribonucleic Acid Binding Protein Gene Cause Familial Dilated Cardiomyopathy
- (2009) Katharine M. Brauch et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- CARDIAC-SPECIFIC OVEREXPRESSION OF INSULIN-LIKE GROWTH FACTOR I (IGF-1) RESCUES lIPOPOLYSACCHARIDE-INDUCED CARDIAC DYSFUNCTION AND ACTIVATION OF STRESS SIGNALING IN MURINE CARDIOMYOCYTES
- (2009) Peng Zhao et al. SHOCK
- Alternative splicing and disease
- (2008) Jamal Tazi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Isoform-Specific Increases in Murine Skeletal Muscle Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α (PGC-1α) mRNA in Response to β2-Adrenergic Receptor Activation and Exercise
- (2008) Shinji Miura et al. ENDOCRINOLOGY
- Antisense technology for the prevention or the treatment of cardiovascular disease: The next blockbuster?
- (2008) Vasilios G Athyros et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Exon organization and novel alternative splicing of the human ANK2 gene: Implications for cardiac function and human cardiac disease
- (2008) Shane R. Cunha et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart
- (2008) A. Kalsotra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Splicing regulation: From a parts list of regulatory elements to an integrated splicing code
- (2008) Z. Wang et al. RNA
- A General Definition and Nomenclature for Alternative Splicing Events
- (2008) Michael Sammeth et al. PLoS Computational Biology
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