Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival

RNA-binding protein HuD reduces triglyceride production in pancreatic β cells by enhancing the expression of insulin-induced gene 1

(2016) Chongtae Kim et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes

(2016) Flora Brozzi et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord

(2016) Janelle C Leggere et al.   eLife

NOVA2-mediated RNA regulation is required for axonal pathfinding during development

(2016) Yuhki Saito et al.   eLife

REST represses a subset of the pancreatic endocrine differentiation program

(2015) David Martin et al.   DEVELOPMENTAL BIOLOGY

The Evolution of Early Neurogenesis

(2015) Volker Hartenstein et al.   DEVELOPMENTAL CELL

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

(2015) Flora Brozzi et al.   DIABETOLOGIA

MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research

(2015) Jonàs Juan-Mateu et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function

(2015) Simona Pedrotti et al.   HUMAN MOLECULAR GENETICS

Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles

(2015) Bushra Raj et al.   NEURON

Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis

(2015) Feifei Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

(2015) Laura Marroqui et al.   EBioMedicine

Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line

(2015) Lotta E. Andersson et al.   PLoS One

RE-1 silencing transcription factor (REST): a regulator of neuronal development and neuronal/endocrine function

(2014) Gerald Thiel et al.   CELL AND TISSUE RESEARCH

Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes

(2014) Patrick Gilon et al.   CELL CALCIUM

Alternative role of HuD splicing variants in neuronal differentiation

(2014) Satoru Hayashi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Nova1 is a master regulator of alternative splicing in pancreatic beta cells

(2014) Olatz Villate et al.   NUCLEIC ACIDS RESEARCH

HITS-CLIP and Integrative Modeling Define the Rbfox Splicing-Regulatory Network Linked to Brain Development and Autism

(2014) Sebastien M. Weyn-Vanhentenryck et al.   Cell Reports

The RNA-binding Protein HuD Regulates Autophagosome Formation in Pancreatic β Cells by Promoting Autophagy-related Gene 5 Expression

(2013) Chongtae Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges

(2013) Michael T Lovci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction

(2013) L. M. Bronicki et al.   RNA

Alternative pre-mRNA splicing in neurons: growing up and extending its reach

(2013) Sika Zheng et al.   TRENDS IN GENETICS

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

(2013) Tatiane C. Nogueira et al.   PLoS Genetics

Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

(2012) D. L. Eizirik et al.   DIABETOLOGIA

The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function

(2012) L. T. Gehman et al.   GENES & DEVELOPMENT

RBFOX1 regulates both splicing and transcriptional networks in human neuronal development

(2012) Brent L. Fogel et al.   HUMAN MOLECULAR GENETICS

RNA-Binding Protein HuD Controls Insulin Translation

(2012) Eun Kyung Lee et al.   MOLECULAR CELL

SpliceAid-F: a database of human splicing factors and their RNA-binding sites

(2012) Matteo Giulietti et al.   NUCLEIC ACIDS RESEARCH

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Dysfunctional gene splicing as a potential contributor to neuropsychiatric disorders

(2011) Stephen J. Glatt et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

β-Cell evolution: How the pancreas borrowed from the brain

(2011) Margot E. Arntfield et al.   BIOESSAYS

Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions

(2011) Thomas L. Gallagher et al.   DEVELOPMENTAL BIOLOGY

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

Gelsolin Associates with the N Terminus of Syntaxin 4 to Regulate Insulin Granule Exocytosis

(2011) Michael A. Kalwat et al.   MOLECULAR ENDOCRINOLOGY

The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain

(2011) Lauren T Gehman et al.   NATURE GENETICS

Networking in a global world: Establishing functional connections between neural splicing regulators and their target transcripts

(2011) J. A. Calarco et al.   RNA

Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program

(2010) J. van Arensbergen et al.   GENOME RESEARCH

Integrative Modeling Defines the Nova Splicing-Regulatory Network and Its Combinatorial Controls

(2010) C. Zhang et al.   SCIENCE

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic  -Cell Apoptosis

(2009) F. Moore et al.   DIABETES

Regulation of insulin secretion: a matter of phase control and amplitude modulation

(2009) J. C. Henquin   DIABETOLOGIA

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches

(2009) Mo Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells

(2008) D. Martin et al.   DIABETOLOGIA

Novel aspects of the molecular mechanisms controlling insulin secretion

(2008) Lena Eliasson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Strong association of de novo copy number mutations with sporadic schizophrenia

(2008) Bin Xu et al.   NATURE GENETICS