Abnormalities in alternative splicing in diabetes: therapeutic targets

Neuron-enriched RNA-binding Proteins Regulate Pancreatic Beta Cell Function and Survival

(2017) Jonàs Juan-Mateu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis

(2017) Joachim Størling et al.   Genes

Apoptosis in pancreatic β-islet cells in Type 2 diabetes

(2016) Tatsuo Tomita   Bosnian Journal of Basic Medical Sciences

Regulation of alternative splicing in human obesity loci

(2016) Dorota Kaminska et al.   Obesity

Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival

(2016) Pushkar Malakar et al.   Scientific Reports

Aberrant mRNA splicing of paired box 4 (PAX4) IVS7-1G>A mutation causing maturity-onset diabetes of the young, type 9

(2015) Jatuporn Sujjitjoon et al.   ACTA DIABETOLOGICA

Mechanisms and Regulation of Alternative Pre-mRNA Splicing

(2015) Yeon Lee et al.   Annual Review of Biochemistry

Type 2 Diabetes Mellitus: Limitations of Conventional Therapies and Intervention with Nucleic Acid-Based Therapeutics

(2015) Ganesh R. Kokil et al.   CHEMICAL REVIEWS

MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research

(2015) Jonàs Juan-Mateu et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Herbal therapy: A review of emerging pharmacological tools in the management of diabetes mellitus in Africa

(2015) AnthonyJide Afolayan et al.   Pharmacognosy Magazine

Inflammation and Hyperglycemia MediateDeaf1Splicing in the Pancreatic Lymph Nodes via Distinct Pathways During Type 1 Diabetes

(2014) Linda Yip et al.   DIABETES

Nova1 is a master regulator of alternative splicing in pancreatic beta cells

(2014) Olatz Villate et al.   NUCLEIC ACIDS RESEARCH

Alternative Splice Forms of CTLA-4 Induced by Antisense Mediated Splice-Switching Influences Autoimmune Diabetes Susceptibility in NOD Mice

(2014) Dan V. Mourich et al.   Nucleic Acid Therapeutics

Mammalian Target of Rapamycin Regulates Nox4-Mediated Podocyte Depletion in Diabetic Renal Injury

(2013) Assaad A. Eid et al.   DIABETES

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

(2013) Miriam Cnop et al.   DIABETES

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation andβ-cell apoptosis

(2013) I. Santin et al.   DIABETES OBESITY & METABOLISM

Role of Moringa oleifera in regulation of diabetes-induced oxidative stress

(2013) Dolly Jaiswal et al.   Asian Pacific Journal of Tropical Medicine

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

(2013) Tatiane C. Nogueira et al.   PLoS Genetics

SRPK1 inhibitionin vivo: modulation of VEGF splicing and potential treatment for multiple diseases: Figure 1

(2012) Sebastian Oltean et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Splice Modulating Therapies for Human Disease

(2012) Pietro Spitali et al.   CELL

Alternative splicing of Bim and Erk-mediated BimEL phosphorylation are dispensable for hematopoietic homeostasis in vivo

(2012) C Clybouw et al.   CELL DEATH AND DIFFERENTIATION

Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism

(2012) D. Kaminska et al.   DIABETES

Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene Expression

(2012) R. Bergholdt et al.   DIABETES

Ethnobotanical survey of medicinal plants used by Bapedi healers to treat diabetes mellitus in the Limpopo Province, South Africa

(2012) S. Semenya et al.   JOURNAL OF ETHNOPHARMACOLOGY

Angiogenesis Impairment in Diabetes: Role of Methylglyoxal-Induced Receptor for Advanced Glycation Endproducts, Autophagy and Vascular Endothelial Growth Factor Receptor 2

(2012) Hongtao Liu et al.   PLoS One

Design principles of interconnections between chromatin and pre-mRNA splicing

(2012) Sérgio F. de Almeida et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming

(2011) Mathieu Gabut et al.   CELL

Expression of the Splicing Factor Gene SFRS10 Is Reduced in Human Obesity and Contributes to Enhanced Lipogenesis

(2011) Jussi Pihlajamäki et al.   Cell Metabolism

An abundant, truncated human sulfonylurea receptor 1 splice variant has prodiabetic properties and impairs sulfonylurea action

(2011) Diethart Schmid et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetics of the HLA Region in the Prediction of Type 1 Diabetes

(2011) Janelle A. Noble et al.   Current Diabetes Reports

The Soluble CTLA-4 Splice Variant Protects From Type 1 Diabetes and Potentiates Regulatory T-Cell Function

(2011) K. D. Gerold et al.   DIABETES

A novel synonymous substitution in the GCK gene causes aberrant splicing in an Italian patient with GCK-MODY phenotype

(2011) Silvia Costantini et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complex

(2011) C. Vandiedonck et al.   GENOME RESEARCH

TCERG1 Regulates Alternative Splicing of the Bcl-x Gene by Modulating the Rate of RNA Polymerase II Transcription

(2011) M. Montes et al.   MOLECULAR AND CELLULAR BIOLOGY

RNAi-based therapeutic strategies for metabolic disease

(2011) Michael P. Czech et al.   Nature Reviews Endocrinology

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

(2011) Esteban N. Gurzov et al.   TRENDS IN CELL BIOLOGY

Management of diabetes mellitus in the elderly

(2011) Niyati Chiniwala et al.   Current Opinion in Endocrinology Diabetes and Obesity

An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis

(2010) Michael J. Moore et al.   CELL

Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis

(2010) F Allagnat et al.   CELL DEATH AND DIFFERENTIATION

Vascular Endothelial Growth Factor (VEGF) in the Pathogenesis of Diabetic Nephropathy of Type 1 Diabetes Mellitus

(2010) Maria Mironidou-Tzouveleki et al.   CURRENT DRUG TARGETS

In vivo Studies on Antidiabetic Plants Used in South African Herbal Medicine

(2010) Anthony J. Afolayan et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

(2010) Toshimasa Yamauchi et al.   NATURE GENETICS

Genomic Medicine — An Updated Primer

(2010) W. Gregory Feero et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alternative splicing in multiple sclerosis and other autoimmune diseases

(2010) Irina Evsyukova et al.   RNA Biology

Beta cell apoptosis in diabetes

(2009) Helen E. Thomas et al.   APOPTOSIS

Detailed transcriptome atlas of the pancreatic beta cell

(2009) Burak Kutlu et al.   BMC Medical Genomics

Maturity-Onset Diabetes of the Young in Children With Incidental Hyperglycemia:: A multicenter Italian study of 172 families

(2009) R. Lorini et al.   DIABETES CARE

Novel mutations in GCK and HNF1A genes in Italian families with MODY phenotype

(2009) Alessia Cappelli et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats

(2009) Dolly Jaiswal et al.   JOURNAL OF ETHNOPHARMACOLOGY

The pathobiology of splicing

(2009) Amanda J Ward et al.   JOURNAL OF PATHOLOGY

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes?

(2008) Cécile Guichard et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Whole genome assessment of the retinal response to diabetes reveals a progressive neurovascular inflammatory response

(2008) Robert M Brucklacher et al.   BMC Medical Genomics

Haploinsufficiency at GCK gene is not a frequent event in MODY2 patients

(2008) Intza Garin et al.   CLINICAL ENDOCRINOLOGY

Identification of CTLA-4 isoforms produced by alternative splicing and their association with myasthenia gravis

(2008) Ming Gu et al.   CLINICAL IMMUNOLOGY

Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor-Induced Apoptosis of Pancreatic  -Cells

(2008) M. D. McKenzie et al.   DIABETES

Diabetes Susceptibility in the Canadian Oji-Cree Population Is Moderated by Abnormal mRNA Processing of HNF1A G319S Transcripts

(2008) L. W. Harries et al.   DIABETES

Thioredoxin-Interacting Protein: A Critical Link Between Glucose Toxicity and  -Cell Apoptosis

(2008) J. Chen et al.   DIABETES

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

(2008) Sergey V Kozyrev et al.   NATURE GENETICS

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

(2008) Eleftheria Zeggini et al.   NATURE GENETICS