The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications

Insulin Receptor Isoforms in Physiology and Disease: An Updated View

(2017) Antonino Belfiore et al.   ENDOCRINE REVIEWS

IGF1 and IGF2 specificities to the two insulin receptor isoforms are determined by insulin receptor amino acid 718

(2017) Mie Andersen et al.   PLoS One

Expression of insulin receptor (IR) A and B isoforms, IGF-IR, and IR/IGF-IR hybrid receptors in vascular smooth muscle cells and their role in cell migration in atherosclerosis

(2016) N. Beneit et al.   Cardiovascular Diabetology

Insulin-Like Growth Factor-1 Receptor Deficiency in Macrophages Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Apolipoprotein E–Deficient MiceCLINICAL PERSPECTIVE

(2016) Yusuke Higashi et al.   CIRCULATION

Prevalent role of the insulin receptor isoform A in the regulation of hepatic glycogen metabolism in hepatocytes and in mice

(2016) Sabela Diaz-Castroverde et al.   DIABETOLOGIA

Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators

(2015) Daniel H. Bedinger et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Insulin receptor isoform A confers a higher proliferative capability to pancreatic beta cells enabling glucose availability and IGF-I signaling

(2015) Oscar Escribano et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Knockdown of IGF2R suppresses proliferation and induces apoptosis in hemangioma cells in vitro and in vivo

(2014) J.-M. OU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss

(2013) Dorota Kaminska et al.   DIABETOLOGIA

mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity

(2013) Xin Li et al.   EMBO REPORTS

Minireview: Nuclear Insulin and Insulin-like Growth Factor-1 Receptors: A Novel Paradigm in Signal Transduction

(2013) Rive Sarfstein et al.   ENDOCRINOLOGY

Implication of Insulin Receptor A Isoform and IRA/IGF-IR Hybrid Receptors in the Aortic Vascular Smooth Muscle Cell Proliferation: Role of TNF-α and IGF-II

(2013) Almudena Gómez-Hernández et al.   ENDOCRINOLOGY

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

(2013) Venus Thomanetz et al.   JOURNAL OF CELL BIOLOGY

Targeting the insulin-like growth factor-1 receptor in human cancer

(2013) Alexandre Arcaro   Frontiers in Pharmacology

Selective Insulin Receptor Modulators (SIRM): A New Class of Antidiabetes Drugs?

(2012) Riccardo Vigneri et al.   DIABETES

Insulin receptor isoforms are differently expressed during human osteoblastogenesis

(2012) Sofia Avnet et al.   DIFFERENTIATION

Insulin-Like Growth Factor 2 in Development and Disease: A Mini-Review

(2012) Daniel Bergman et al.   GERONTOLOGY

Insulin and Insulin-like Growth Factor II Differentially Regulate Endocytic Sorting and Stability of Insulin Receptor Isoform A

(2012) Alaide Morcavallo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of IGF-2R stimulates cardiomyocyte hypertrophy in the late gestation sheep fetus

(2012) Kimberley C. W. Wang et al.   JOURNAL OF PHYSIOLOGY-LONDON

PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12

(2012) Xiaoqing Gan et al.   NATURE CELL BIOLOGY

Molecular Basis of Signaling Specificity of Insulin and IGF Receptors: Neglected Corners and Recent Advances

(2012) Kenneth Siddle   Frontiers in Endocrinology

Biology and significance of signalling pathways activated by IGF-II

(2011) Lynda K. Harris et al.   GROWTH FACTORS

Smooth Muscle Cell–Specific Insulin-Like Growth Factor-1 Overexpression in Apoe −/− Mice Does Not Alter Atherosclerotic Plaque Burden but Increases Features of Plaque Stability

(2010) Shaw-Yung Shai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Insulin Signaling to the Glomerular Podocyte Is Critical for Normal Kidney Function

(2010) Gavin I. Welsh et al.   Cell Metabolism

Direct Recruitment of Insulin Receptor and ERK Signaling Cascade to Insulin-Inducible Gene Loci

(2010) J. D. Nelson et al.   DIABETES

Glucose binds to the insulin receptor affecting the mutual affinity of insulin and its receptor

(2009) Robert Root-Bernstein et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

 -Cell Hyperplasia Induced by Hepatic Insulin Resistance: Role of a Liver-Pancreas Endocrine Axis Through Insulin Receptor A Isoform

(2009) O. Escribano et al.   DIABETES

A brief perspective on insulin production

(2009) D. F. Steiner et al.   DIABETES OBESITY & METABOLISM

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Human aortic smooth muscle cells are insulin resistant at the receptor level but sensitive to IGF1 and IGF2

(2009) S I Chisalita et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of Insulin-Like Growth Factor II Receptor Induces Mitochondrial-Dependent Apoptosis through Gαq and Downstream Calcineurin Signaling in Myocardial Cells

(2008) Chun-Hsien Chu et al.   ENDOCRINOLOGY

The ontogeny of genes related to ovine fetal cardiac growth

(2008) Seth A. Reini et al.   GENE EXPRESSION PATTERNS

IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Gαq interaction and protein kinase C-α/CaMKII activation in H9c2 cardiomyoblast cells

(2008) Chun-Hsien Chu et al.   JOURNAL OF ENDOCRINOLOGY

Evolution of the Insulin Receptor Family and Receptor Isoform Expression in Vertebrates

(2008) C. Hernandez-Sanchez et al.   MOLECULAR BIOLOGY AND EVOLUTION

Insulin-Like Signaling, Nutrient Homeostasis, and Life Span

(2007) Akiko Taguchi et al.   Annual Review of Physiology